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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Functional analysis of Trypanosoma brtwei PUF1 显示文摘 | Luu VD Brems S Hoheisel JD | 2006 | Mol Biochem Parasitol2006，150，2： | 1 |
| 3 | A strategy for evalua- ting a fuzzy case-based construction procurement selection system显示文摘 | LUU D T NG S T CHEN S E | 2006 | Advances in Engineering Software2006，37，3： | 1 |
| 4 | Toxicogenomics of A375 hunmn malignant melanoma cells treated with arbutin 显示文摘 | CHENG S K LUU R H SHEU J N | 2007 | Journal of Biomedical Science2007，14，1： | 1 |
| 5 | Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation显示文摘 | Yang YH Dudoit S Luu P | 2002 | Nucleic Acids Research2002，30，： | 1 |
| 6 | Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PGA block copolymers显示文摘 | Y K Luu K Kim B S Hsiao | 2003 | Journal of Controlled Release2003，89，： | 1 |
| 7 | Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation 显示文摘 | Yang Y H Dudoit S Luu P | 2002 | Nucleic Acids Res2002，30，4： | 1 |
| 8 | Hadrosaurian dinosaurs of North America显示文摘 | LuU R S Wright N E | 1942 | Geological Society of America Special Paper1942，40，： | 1 |
| 9 | Polycarbonate bottle use and urinary bisphenol A concentrations 显示文摘 | CARWILE J L LUU H T BASSETT L S | 2009 | Environ Health Perspect2009，117，9： | 1 |
| 10 | Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation 显示文摘 | Yang YH Dudoit S Luu P | 2002 | Nucleic Acids Res2002，30，4： | 1 |
| 11 | Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation 显示文摘 | Yang YH Dudoit S Luu P | 2002 | Nucleic Acids Res2002，30，4： | 1 |
| 12 | Design of a Satellite Cluster System in Distributed Simulation显示文摘 | Lee J S Luu T | 2005 | Simulation2005，81，1： | 1 |
| 13 | Review:Microbial mechanisms of accessing in- soluble Fe(III) as an energy source 显示文摘 | LUU Y S RAMSAY J A | 2003 | World J Microbial Biotech2003，19，： | 1 |
| 14 | Hydrogen permeation through nickel-plated steel显示文摘 | Luu W C Kuo H S Wu J K | 1997 | Corrosion Science1997，39，6： | 1 |
| 15 | Orbital debris hazard assessment methodologies for satellite constellations 显示文摘 | Spencer D B Luu K K Campbell W S etal | 2001 | Journal of Spacecraft and Rockets2001，38，1： | 1 |
| 16 | Hydrogen permeation in a submerged arc weldment of TMCP steel显示文摘 | Wang S H Luu W C Ho K F | 2003 | Materials Chemistry and Physics2003，77，2： | 1 |
| 17 | Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation显示文摘 | Yang Y H Dudoit S Luu P | 2002 | Nucleic Acids Research2002，30，4： | 1 |
| 18 | Pharmacokinetics and pharmacodynamics of ramipril and piretanide administrated alone and in combination显示文摘 | Ruf G Gera S Luus HG Trerk D de la Rey N Loffler K | 1994 | Eur J Clin Pharmacol1994，46，： | 1 |
| 19 | Space shuttle testing of the TriDAR 3D rendezvous and docking sensor 显示文摘 | RUEL S LUU T BERUBE A | 2012 | Journal of Field Robotics2012，29，4： | 1 |
| 20 | Normalization for cDNA mi- croarray data:a robust composite method addressing single and multiple slide systematic variation显示文摘 | Yang YH Dudoit S Luu P | 2002 | Nucleic Acids Res2002，30，4： | 1 |
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