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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro显示文摘AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) cells.METHODS: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine stimulation.RESULTS: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic conditions.CONCLUSION: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and on the role of the CA9 gene as a positive disease regulator in human cancer. | Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said | 2012 | World Journal of Clinical Oncology2012，3，6： | 2 |
| 3 | A Surface Analyt ical Study of Functionalized Mild Steel for Adhesion Pro motion of Organic Coatings显示文摘 | HARUN M K LYON S B MARSH J | 2003 | Progress in Organic Coat ings2003，46，11： | 1 |
| 4 | 2,6- Disubstituted imidazo thiadiazoles : Search for anticancer agent 显示文摘 | Malleshappa N N Harun M P Sarita K | 2012 | European Journal of Medicinal Chemistry2012，56，： | 1 |
| 5 | Bioprocess engineering of microalgae to produce a variety of consumer products显示文摘 | Harun R Singh M Forde G M | 2010 | Renewable and Sustainable Energy Reviews2010，14，3： | 1 |
| 6 | Effect of physical pretreatment on dilute acid hydrolysis of water hyacinth (Eichhornia crassipes) 显示文摘 | Harun M Y Dayang Radiah A B Zainal Abidin Z | 2011 | Bioresource Technology2011，102，8： | 1 |
| 7 | Hospitality language as an professional Skill 显示文摘 | George Blue M Minah Harun | 2003 | English for Specific Purposes2003，，22： | 1 |
| 8 | Bioprocess engineering of microalgae to produce a variety of consumer products显示文摘 | Harun R Singh M Forde G M | 2010 | Renewable and Sustainable Energy Reviews2010，14，3： | 1 |
| 9 | The effect of surface modification on the cathodic disbondment rate of epoxy and alkyd coatings 显示文摘 | HARUN M K MARSH J LYON S B | 2005 | Progress in Organic Coatings2005，54，4： | 1 |
| 10 | Does Non-farm income improve the poverty and income inequality among agricultural household in rural Kedah? 显示文摘 | MAT S H JALIL A HARUN M | 2012 | Procedia Economics and Finance2012，，1： | 1 |
| 11 | A prototype of KBS for material selection in bumper beam design 显示文摘 | SUDDIN M N HARUN M R HAMZAH A T ANUAR S | 2007 | Suranaree Journal Science Technology2007，14，： | 1 |
| 12 | A surface analyticalstudy of functionalised mild steel for adhesion promotion of organic coatings显示文摘 | Harun M K Lyon S B Marsh J | 2003 | Progress in Organic Coatings2003，46，1： | 1 |
| 13 | Crafting engineering problems for problem-based learning curriculum显示文摘 | Jamaludin M Z Mohd-Yusof K Harun N F | 2012 | Procedia-Social and Behavioral Sciences2012，，56： | 1 |
| 14 | Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo E2, l-b] -thiadiazole derivatives 显示文摘 | Malleshappa N N Harun M P Singh N | 2011 | European Journal of Medicinal Chemistry2011，46，9： | 1 |
| 15 | A surface analytical study of functionalized mild steel for adhesion promotion of or ganic coatings显示文摘 | HARUN M K LYON S B MARSH J | 2003 | Progress in Organic Coatings2003，46，： | 1 |
| 16 | A before-and-after study on green signal countdown device installation显示文摘 | Lum K M Harun H | | 0，，： | 1 |
| 17 | Microalgal cell disruption for biofuel development 显示文摘 | Halim R Harun R Danquah M K | 2012 | Applied Energy2012，91，1： | 1 |
| 18 | Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives : Search for anticancer agent 显示文摘 | MALLESHAPPA N N HARUN M P VARUN B | 2011 | Eur J Med Chem2011，46，6： | 1 |
| 19 | Particle swarm optimization feedforward neural network for modeling runoff显示文摘 | Kuok K K Harun S Shamsuddin S M | 2010 | hatemational Journal of Environmental Science and Technology2010，7，1： | 1 |
| 20 | Evaluation of rubber/mild steel bonds failure after exposure in marine environment 显示文摘 | Ismaliza Ismail M K Harun | 2013 | International Journal of Chemical Engineering and Ap- plications2013，4，3： | 1 |
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