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| 1 | Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment显示文摘Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages. | Adebola Matthew Giwa Rizwan Ahmed Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad | 2020 | World Journal of Diabetes2020，11，1： | 2 |
| 2 | Vascμlar endothelial growth factor is an autocrine growth factor for VEGF receptor-positive human tumors显示文摘 | Rizwan M Jie C Tong Z | 2001 | Blood2001，98，6： | 1 |
| 3 | Effect of spacer length of alkanediyl - a, to - bis ( dimethylcetylammonium bromide) gemini homologues on the interfacial and physicochemical properties of BSA显示文摘 | MOHAMMADO A M JAVEED M K RIZWAN H K | 2010 | Colloids and Surfaces B : Biointerfaces2010，77，1： | 1 |
| 4 | Photodermatoses: environ- mentally induced conditions with high psychological impact 显示文摘 | Rizwan M Reddick CL Bundy C | 2013 | Pho- tochem Photobiol Sci2013，12，1： | 1 |
| 5 | Famide-related pep- tide-3 receptor gene expression in GnRH and kisspeptin neu- rons and GnRH-dependent mechanism of action显示文摘 | Rizwan M Z Poling M C Corr M | 2012 | Endocrinolo- gy2012，153，8： | 1 |
| 6 | Effectiveness of organic bio-fertilizer supplemented with chemical fertilizer for improving soil water retention, aggregate stability, growth and nutrient uptake of maize显示文摘 | RIZWAN A ARSHAD M KHALID A | 2008 | Journal of Sustainable Agriculture2008，34，： | 1 |
| 7 | Rapunzel syndrome -A rare cause of multiple jejuna intussusceptions 显示文摘 | Rizwan K Sonia M | 2009 | Southern Medical Asso- ciation2009，38，： | 1 |
| 8 | Granulocytic sarcoma ofthe male breast in acute myeloblastic leukemia with concurrentdeletion of 5q and trisomy 8 显示文摘 | Rizwan M Islam MM Rehman ZU | 2012 | Case Rep Hematol2012，2012，19： | 1 |
| 9 | Selention, resistance risk assessment and reversion toward susceptibility of pyriproxyfen in Musca domestica L 显示文摘 | Rizwan M Naeem A Sarfraz A | 2015 | Parasitol Res2015，114，： | 1 |
| 10 | Advancement in carbon nanotubes: basics, biomedical applications and toxicity 显示文摘 | Beg S Rizwan M Sheikh AM | 2011 | J Pharm Pharmacol2011，63，2： | 1 |
| 11 | Fabrication, growth mechanism and antibacterial activity of ZnO micro-spheres prepared via solution process 显示文摘 | Rizwan W Amrita M Soon-I1 Y | 2012 | B/omass & B/oenergy2012，39，： | 1 |
| 12 | Rapunzel syndrome-A rare cause of multiple jejuna intussusceptions显示文摘 | Rizwan K Sonia M | | 0，，： | 1 |
| 13 | Expression of cholera toxin B subunit in transgenic tomato plants 显示文摘 | JANI D MEENA L S RIZWAN - UL - HAQ Q M | 2002 | Transgenic Research2002，11，5： | 1 |
| 14 | Enhanced transdermal drug delivery techniques:an extensive review of patents 显示文摘 | Rizwan M Aqil M Talegaonkar S | 2011 | Recent Pat Drug Deliv Formul2011，3，2： | 1 |
| 15 | Effectiveness of organic bio-fertilizer supplemented with chemical fertilizer for improving soil water retention,aggregate stability,growth and nutrient uptake of maize显示文摘 | Rizwan A Arshad M Khalid A | 2008 | Journal of Sustainable Agriculture2008，34，： | 1 |
| 16 | Churn prediction in telecom using Random Forest and PSO based data balancing in combination with various feature selection strategies 显示文摘 | Idris A Rizwan M Khan A | 2012 | Computers & Electrical Engineering2012，38，6： | 1 |
| 17 | Enhanced transdermal drug delivery techniques:an extensive review of patents显示文摘 | Rizwan M Aqil M | 2009 | Recent Pat Drug Deliv Formul2009，3，2： | 1 |
| 18 | Advancement in carbon nanotubes: basics, biomedical applications and toxicity 显示文摘 | BEG S RIZWAN M SHEIKH A M | 2011 | J Pharm Pharmacol2011，63，2： | 1 |
| 19 | Enhanced trans- dermal delivery of carvedilol using nanoemulsion as a vehicle 显示文摘 | Rizwan M Aqil M Azeem A | 2010 | Journal of Experimental Nanoscience2010，5，5： | 1 |
| 20 | Low-temperature synthesis of Zn O quantum dots for photocatalytic degradation of methyl orange dye under UV irradiation显示文摘 | RIZWAN K HASSAN S M JANG L W | 2014 | Ceramics international2014，40，14： | 1 |
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