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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Course of illness,hippocampal function and hippocampal volume in major depression显示文摘 | Mac Queen G M Campbell S McEwen B S | 2003 | PNAS2003，100，3： | 1 |
| 3 | Anaerobic digestion of organicsolid wastes:Anoverview of research achievements and perspectives显示文摘 | Alvarez J M Macés L P | | 0，，74： | 1 |
| 4 | Deletion of dentin matrix protein-1 leads to a partpal failure of maturation of pre- dentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development 显示文摘 | YE L MAC DOUGALL M ZHANG S | 2004 | Biol Chem2004，279，18： | 1 |
| 5 | Study of thermal properties andheat-induced denaturation and aggregation of soy proteins by modulated differential scanning calorimetry显示文摘 | TANG Chuanhe CHOI S M MAC Y | 2007 | International Journal of Biological Macromolecules2007，40，： | 1 |
| 6 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 7 | Study of thermal aggregation of globulin from common buckwheat (Fagopyrum esculentum Moench) by size- exclusion chromatography and laser light scattering显示文摘 | CHOI S M MAC Y | 2006 | Jourmal of Agricultural and Food Chemistry2006，54，1： | 1 |
| 8 | Coordinated charging of plug-in hybrid electric vehicles to minimize distribution system losses显示文摘 | ERIC S MOHAMMAD M H JAMES MAC PHERSON S D | 2011 | IEEETransOilSmartGrid2011，2，1： | 1 |
| 9 | Organizational citizenship behaviors:a critical review of the theoretical and empirical literature and suggest ions for future research显示文摘 | Podsakoff P M Mac Kenzie S B Julie Beth Paine | 2000 | Journal of Management2000，，3： | 1 |
| 10 | Protein complexes activate distinct caspase cascades in death receptor and stressinduced apoptosis显示文摘 | BRATTON S B MAC FARLANE M CAIN K | 2000 | Exp Cell Res2000，256，1： | 1 |
| 11 | Progno- sis in pediatric idiopathic pulmonary hemosiderosis 显示文摘 | Saeed M M Woo M S Mac Laughlin E F | 1999 | Chest1999，116，3： | 1 |
| 12 | Philosophy of environmentd enrichment: past, present, and future显示文摘 | MELLEN J MAC PHEE M S | 2001 | Zoo Biology2001，，3： | 1 |
| 13 | Analysis of die behavior during bulge forming operations using the finite element method 显示文摘 | Mac B J D Kashmir M S J | 2002 | Finite Elements in Analysis and Design2002，39，： | 1 |
| 14 | 查看详情显示文摘 | Marques R S Mac Leod T C O Yoshida I V P Mano V Assis M D Schiavon M A | | 0，，： | 1 |
| 15 | Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects显示文摘 | Harris S E Mac Dougall M Horn D | 2012 | Bone2012，50，1： | 1 |
| 16 | Intramedullary tuberculomas of the spinal cord:case report and review显示文摘 | MAC DONELL A H BAIRD R W BRONZE M S | 1990 | Rev Infect1990，12，： | 1 |
| 17 | Superox- ide radicaland xanthine oxidoreductase activity in the human heart during cardiac operations 显示文摘 | Mac Gowan S M Regan M C Malone C | 1995 | Ann Thorac Surg1995，60，5： | 1 |
| 18 | Evaluation of the spoilage potential of bacteria isolated from spoiled cooked whole tropical shrimp (Penaeus vannamei) stored under modified atmosphere packaging显示文摘 | Macé S Cardinal M Jaffrès E | 2014 | Food Microbiology2014，40，： | 1 |
| 19 | Photosensitizer method to determine rate constants for the reaction of carbonate radical with organic compounds显示文摘 | Canonica S Kohn T Mac M | 2005 | Environ Sci Technol2005，39，23： | 1 |
| 20 | The impact of organizational citizenship behavior on evaluations of salesperson performance显示文摘 | MAC KENZIE S B PODSAKOFF P M FETTER R | 1993 | Journal of Marketing1993，57，： | 1 |
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