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| 1 | Excretion of biliary compounds during intrauterine life显示文摘In adults,the hepatobiliary system,together with the kidney,constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine,respectively.However,during intrauterine life the biliary route of excretion for cholephilic compounds,such as bile acids and biliary pigments,is very poor.Although very early in pregnancy the fetal liver produces bile acids,bilirubin and biliverdin,these compounds cannot be efficiently eliminated by the fetal hepatobiliary system,owing to the immaturity of the excretory machinery in the fetal liver.Therefore,the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta.Owing to the presence of detoxifying enzymes and specifi c transport systems at different locations of the placental barrier,such as the endothe-lial cells of chorionic vessels and trophoblast cells,this organ plays an important role in the hepatobiliary-like function during intrauterine life.The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother.This may result in oxidative stress and apoptosis,mainly in the placenta and fetal liver,which might affect normal fetal development and challenge the fate of the pregnancy.The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem. | Rocio IR Macias Jose JG Marin Maria A Serrano | 2009 | World Journal of Gastroenterology2009，15，7： | 6 |
| 2 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 3 | Diabetes insipidus and adipsic hypermatremia in a patient with a craniopharyngioma显示文摘 | Macias Batista A Martinez Martin F J de Pablos Velasco PL | 1999 | An Med Interna1999，16，2： | 1 |
| 4 | Effect of maternal cholestasis on bile acid transfer across the rat placenta-maternal liver tandem 显示文摘 | MACIAS R I PASCUAL M J BRAVO A | 2000 | Hepatology2000，31，4： | 1 |
| 5 | Chemical composition of fumarolic gases and spring discharges from EI Chichon volcano,Mexico:Causes and implications of the changes detected over the period 1998-2000显示文摘 | Tassi F vaselli O Capaccioni B Macias J Ⅰ Nencetti A | 2003 | Journal of Volcanology and Geothermal Resesrch2003，，123： | 1 |
| 6 | Allelopathy--a natural alternative for weed control 显示文摘 | Macias F A MoliniLlo J M G Varela R M | 2007 | Pest Management Science2007，63，4： | 1 |
| 7 | Overlaping patterns of activation of human endothelial cells by interleukin-1, tumor necrosis factor and immune interferon 显示文摘 | MACIAS C VILLAESCUSA M A | 2003 | Immumo2003，56，1： | 1 |
| 8 | Improved analytical fit of gold dispersion : Application to the modeling of extinction spectra with a finite-difrerence time-domain method显示文摘 | VIAL A GRIMAULT A S MACIAS D | 2005 | Phys Rev B2005，71，08： | 1 |
| 9 | Bioactivepolar triterpenoids from Melilotus messanensis显示文摘 | Macias F A Simonet A M Galindo J C G er al | 1998 | Phytochemistry1998，49，3： | 1 |
| 10 | Serous otitis media in children:implication of Alloiococcus otitidis显示文摘 | DE MIGUEL MARTINEZ I MACIAS A R | 2008 | Otol Neurotol2008，29，： | 1 |
| 11 | Immobilization of glucose oxidase within calcium alginate gel capsules 显示文摘 | Blandino A Macias M Cantero D | 2001 | Process Biochemistry2001，36，： | 1 |
| 12 | Catalytic properties of ZrO2-SiO2: Effects of sulfating in the cyclohexene isomerization 显示文摘 | Navio J A Colon G Macias M | 1996 | Journal of Catalysis1996，161，： | 1 |
| 13 | Bioactivephenolics and polar compounds from Melilotusmessanensis显示文摘 | Macias F A Simonet A M Galindo J CG | 1999 | Phytochemistryf1999，50，1： | 1 |
| 14 | Chronic pseudomonas aeruginosa infection in chronic obstructive pulmonary disease显示文摘 | Martinez-Solano L Macia M D Fajardo A | | 0，，： | 1 |
| 15 | Sleep in schizophrenia:a preliminary study using the Pittsburgh sleep quality index显示文摘 | Royuela A Macias JA Gil-Verona JA | 2002 | Neurobiology of Sleep-Wakefulness Cycle2002，2，： | 1 |
| 16 | Functionalisation versus mineralisation of someN-heterocyclic compounds upon UV-illumination in thepresence of un-doped and iron-doped TiO2photocatalysts显示文摘 | NAVIO J A MACIAS M GARCIA-GOMEZ M | 2008 | Application Catalysis BEnvironmental2008，82，34： | 1 |
| 17 | Complexes of Ti (Ⅳ) with Schiff Bases Containing Pyridine and N-methylpyrrole显示文摘 | Parrado C Bastida R Macias A | 1994 | Synth React Inorg Met Org Chem1994，24，9： | 1 |
| 18 | Urokinase type plasminogen activator and plasminogen ac tivator inhibitors (PA-1 and PAI 2) in extracts of invasive cer vical carcinoma and precursor lesions显示文摘 | Daneri navarro A Macias lopez G Oceguera villanueva A | 1998 | Eur J Cancer1998，34，4： | 1 |
| 19 | Immobilization of glucose oxidase within calcium alginate gel capsules 显示文摘 | BLANDINO A MACIAS M CANTERO D | 2001 | Process Biochemistry2001，36，7： | 1 |
| 20 | Thoracoscopic anatomical resection of congenital lung malformations in adults 显示文摘 | MACIAS L OJANGUREN A DAHDAH J | 2015 | J Thorac Dis2015，7，3： | 1 |
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