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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | 巨噬细胞中缺氧诱导因子1α表达促进动脉粥样硬化的发展显示文摘粥样硬化病变包含缺氧区域,但缺氧病理生理的重要性未知。缺氧诱导因子1a(hypoxia-induciblefactor-1α,HIF-1α)是细胞对低氧反应的关键转录因子。研究人员对HIF-1α在巨噬细胞促进小鼠动脉粥样硬化的生物学效应方面进行调查和验证。 | 刘莉 叶鹏 Aarup A Pedersen TX Junker N Christoffersen C Bartels ED Madsen M Nielsen CH Nielsen LB | 2016 | 中华高血压杂志2016，24，9： | 3 |
| 3 | Wave reflection from a vertical permeable wave absorber 显示文摘 | Madsen P A | 1983 | Coastal Engineering1983，，7： | 2 |
| 4 | The interaction between water movement,sediment dynamics and submersed macrophyte显示文摘 | MADSEN J D CHAMBERS P A JAMES W F | 2001 | Hydrobiologia2001，，444： | 1 |
| 5 | Decorrelation in interferometricradar echoes显示文摘 | Zebker H A Madsen S N | 1992 | IEEE Trans Geosci Remote Sens1992，30，5： | 1 |
| 6 | Optically stimulated luminescence dating of young estuarine sediments:a comparison with210Pb and 137Cs dating显示文摘 | Madsen A T Murray A S Andersen T J | 2005 | Marine Geology2005，214，： | 1 |
| 7 | Baker's Yeast: Production of D- and L-3-Hydroxy Esters 显示文摘 | Dahl A C Madsen J O | 1998 | Tetrahedron: Asymmetry1998，9，： | 1 |
| 8 | Sensitive detection and typing of porcine reproductive and respiratory syndrome virus by RT-PCR amplification of whole viral genes显示文摘 | Olekslewica M B Botner A Madsen K G | 1998 | Vet Microbiology1998，64，1： | 1 |
| 9 | A new form of the Boussinesq equations with improved linear dispersion characteristics- Part 2: A slowly-varying bathymetry 显示文摘 | Madsen P A Sorensen O R | 1992 | Coastal Engineering1992，18，43： | 1 |
| 10 | Unstable sacral fractures: associated injuries and morbidity at 1 year 显示文摘 | Totterman A Glott T Madsen JE | 2006 | Spine ( Phila Pa 1976)2006，31，18： | 1 |
| 11 | Localization of lung surfactant protein D on mucosal surfaces in human tissues显示文摘 | Madsen J Kliem A Tornoe I | 2000 | J Immunol2000，164，11： | 1 |
| 12 | Detection and typing of porcinere productive and respiratory syndromevirus by RT PCR amplification of whole vira lgene 显示文摘 | Oleksiewiea M B Botner A Madsen K G | 1998 | J Vet Microbiology1998，64，： | 1 |
| 13 | Characterization of the deposition and materials parameters of thin-film TiNi for micro-actuators and smart materials 显示文摘 | JARDINE A P MADSEN J S MERCADO P G | 2004 | Materials characterization2004，32，： | 1 |
| 14 | Papillary glioneuro-nal tumor--a new tumor entity 显示文摘 | Broholm H Madsen F F Wagner A A | 2002 | Clin Neuropathol2002，21，1： | 1 |
| 15 | Bound waves and triad interactions in shallow water显示文摘 | Madsen P A Sфrensen O R | 1993 | Ocean Engng1993，20，： | 1 |
| 16 | Characterization of the Deposition and Materials Parameters of Thin-film TiNi for Microactuators and Smart Materials 显示文摘 | Jardine A P Madsen J S Mercado P G | 1994 | Mater Chara1994，32，3： | 1 |
| 17 | Cramer-Rao bounds for the estimation of multipath parameters and mobiles positions in asynchronous DS-CDMA systems 显示文摘 | BOTTERON C MADSEN A H FATTOUCHE M | 2004 | IEEE Trans on Signal Processing2004，52，4： | 1 |
| 18 | Reverse transcriptase real - time PCR for detection and quantification of viable Campylobacter jejuni directly from poultry faecal samples 显示文摘 | Bui XT Wolff A Madsen M | 2012 | Res Microbiol2012，163，1： | 1 |
| 19 | Increased neurogenesia in a modd of electroconvulsive therapy显示文摘 | Madsen T M Tresehow A Bengzon J | 2000 | Biol Psychiatry2000，47，12： | 1 |
| 20 | Bakers' Yeast: Improving the D-Stereoselectivity in Reduction of 3-Oxo Esters 显示文摘 | Dahl A C Fjeldberg M Madsen J O | 1999 | Tetrahedron:Asymmetry1999，10，3： | 1 |
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