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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Differentiation of infection from vaccination in foot-and-mouth disease by the detection of antibodies to the non-structural proteins 3D, 3AB, and 3ABC in ELISA using antigens expressed in baculovirus 显示文摘 | Sorensen K J Madsen K G Madsen E S | | Arch V0，，： | 2 |
| 3 | Transcribed her-eroplasmic repeated sequences in the porcine mitochondrial DNA D-loop region显示文摘 | Ghlvlzzani SC Mackay SL Madsen C S | 1993 | J Mol Evol1993，37，1： | 1 |
| 4 | A receptor kinase gene of the LysM type is involved in legume perception of rhizobial signals显示文摘 | Madsen E B Madsen L H Radutoiu S | 2003 | Nature2003，425，： | 1 |
| 5 | Parameter estimation in stochastic grey-box models 显示文摘 | KRISTENSEN N R MADSEN H JORGENSEN S B | 2003 | IFAC Journal of Automatica2003，40，2： | 1 |
| 6 | Effect of salinity on expression of branchial ion transporters in striped bass (Morone saxatilis)显示文摘 | Tipsmark C K Madsen S S Borski R J | 2004 | J Exp Zool A2004，301，12： | 1 |
| 7 | Expression of Na^+-K^+-AT- Pase in the brown trout,Salmo trutta: in vivo modulation by hormones and seawater显示文摘 | I MADSEN S S JENSEN M K NHR J | 1995 | Am J Physiol1995，269，： | 1 |
| 8 | Decorrelation in interferometricradar echoes显示文摘 | Zebker H A Madsen S N | 1992 | IEEE Trans Geosci Remote Sens1992，30，5： | 1 |
| 9 | Optically stimulated luminescence dating of young estuarine sediments:a comparison with210Pb and 137Cs dating显示文摘 | Madsen A T Murray A S Andersen T J | 2005 | Marine Geology2005，214，： | 1 |
| 10 | Estimating the doppler centroid of SAR data显示文摘 | Madsen S N | 1989 | IEEE Transactions on Aerospace and Electronic System1989，25，： | 1 |
| 11 | Wave-induced pore pressure and effective stresses in a porous bed显示文摘 | Madsen O S | 1978 | Geotechnique1978，28，4： | 1 |
| 12 | Treatment of trichodiniasis in eel Anguilla anguillareared inrecirculation systems in Denmark:alternatives to formaldehyde显示文摘 | MADSEN H CK BUCHMANN K MELLERGAARD S | 2000 | Aquaculture2000，186，： | 1 |
| 13 | Wave-induced pore pressure and effective stresses in a porous bed显示文摘 | MADSEN O S | 1978 | Journal of Geotechnical Engineering American Society of Civil Engineering1978，28，4： | 1 |
| 14 | Uric acid in patients with angiographically documented coronary heart disease 显示文摘 | PETERSEN T S MADSEN T V JESPERSEN J B | 2006 | Acta Cardiol2006，61，： | 1 |
| 15 | Characterization of the deposition and materials parameters of thin-film TiNi for micro-actuators and smart materials 显示文摘 | JARDINE A P MADSEN J S MERCADO P G | 2004 | Materials characterization2004，32，： | 1 |
| 16 | Bound waves and triad interactions in shallow water显示文摘 | Madsen P A Sфrensen O R | 1993 | Ocean Engng1993，20，： | 1 |
| 17 | Global account management:The new frontier in relationship management显示文摘 | Yip G S and Madsen T L | 1996 | International Marketing Review1996，13，3： | 1 |
| 18 | Characterization of the Deposition and Materials Parameters of Thin-film TiNi for Microactuators and Smart Materials 显示文摘 | Jardine A P Madsen J S Mercado P G | 1994 | Mater Chara1994，32，3： | 1 |
| 19 | Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study 显示文摘 | Zander M Madsbad S Madsen JL | 2002 | Lancet2002，359，： | 1 |
| 20 | Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process显示文摘 | Madsen L1 Petersen RK S(φ)rensen MB | 2003 | Biochem J2003，375，： | 1 |
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