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| 1 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 2 | Future Directions for Magnetic Sensors for Space Applications 显示文摘 | Magnes W Diaz-Michelena M | 2009 | IEEE Transactions on Magnetics2009，45，10： | 1 |
| 3 | Mitral repair versus replacement for ischemic mitral regurgitation:comparison of short-term and long-term survival显示文摘 | MAGNE J GIRERD N SéNéCHAL M | 2009 | Circulation2009，120，11： | 1 |
| 4 | The interactions between asbestos fibers and metaphase chromosomes of rat pleural mesothelial cells in culture, A scanning and transmission electron microscopic study 显示文摘 | WANG N S JAURAND M C MAGNE L | 1987 | Am J Pathol1987，126，2： | 1 |
| 5 | VEGF and VEGF receptors are differentially expressed in chondrocytes显示文摘 | Bluteau G Julien M Magne D | 2007 | Bone2007，40，3： | 1 |
| 6 | Mitral repair versus replacement for ischemic mitral regurgitation comparison of short-term and long-term survival显示文摘 | Magne J Girerd N Senechal M | 2009 | Circulation2009，120，11： | 1 |
| 7 | Metastasis of a lumbosacral ependymoma with very long disease-free survival:a case report and review of the literature 显示文摘 | Castadot P Magne N Roelandts M | 2006 | Cancer Radiother2006，10，3： | 1 |
| 8 | La place de la meiosi clans le cycle de development de Porphyra umbilicalis 显示文摘 | Giraud A Magne F M | 1968 | C R Acad Sci (Paris) Ser D1968，267，： | 1 |
| 9 | Cooperative luminescence in an ytterbium-doped silica fiber显示文摘 | Magne S Querdane Y Druetta M | 1994 | Opt Commun1994，111，： | 1 |
| 10 | VEGF and VEGF receptors are differentially expressed in chondrocytes显示文摘 | Bluteau G Julien M Magne D | 2007 | Bone2007，40，3： | 1 |
| 11 | Phosphate stimulates matrix gla protein expression in chondrocytes through the extracellular siglaal regulated kinase signaling pathway 显示文摘 | Julien M Magne D Masson M | 2007 | Endocrinology2007，148，2： | 1 |
| 12 | The new IL-1 family member IL-1F8 stimulates productionof inflammatory mediators by synovial fibroblasts and articu-lar chondrocytes显示文摘 | Magne D Palmer G Barton JL Mezin F Talabot-Ayer D Bas S Duffy T Noger M Guerne PA Nicklin MJ GabayC | 2006 | Arthritis Res Ther2006，8，3： | 1 |
| 13 | Nitrate reduction,nitrite reduction and ammonium assimilation in barley roots in response to anoxia显示文摘 | Botrel A Magne C Kaiser W M | 1996 | Plant Physiology and Biochemistry1996，34，5： | 1 |
| 14 | The esthetic width in fixed prosthodontics显示文摘 | Magne P Magne M Belser U | 1999 | J Prosthodont1999，8，2： | 1 |
| 15 | Diagnostic mock-ups as an objective tool for predictable outcomes with porcelain laminate veneers in estheti- callydemanding patients:a clinical report显示文摘 | Reshad M Cascione D Magne P | 2008 | J Prosthet Dent2008，99，5： | 1 |
| 16 | Uhra-wideband waveform generator based on optical pulse shaping and FBG tuning 显示文摘 | ABTAHI M MIRSHAFIEI M MAGNE J | 2008 | IEEE Photon Technol Lett2008，20，2： | 1 |
| 17 | General active global stabilization of multiloads DC-power networks 显示文摘 | MAGNE P NAH1D M B PlERFEDERICI S | 2012 | IEEE Transactions on Power Electronics2012，27，4： | 1 |
| 18 | Cooperative luminescence in an ytterbium-doped silica fiber 显示文摘 | MAGNE S OUERDANE Y DRU- ETTA M | 1994 | Opt Commun1994，111，： | 1 |
| 19 | Musician Children Detect PitchViolations in both Music and Language Better than Nonmusi-cian Children:Behavioral and Electrophysiological Approaches显示文摘 | Magne C Schn D Besson M | 2006 | Journal of Cognitive Neuroscience2006，18，2： | 1 |
| 20 | Ischemic mitral regurgi-tation:a complex multifaceted disease显示文摘 | Magne J Senechal M Dumesnil JG | | 0，，： | 1 |
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