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| 1 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 2 | Clinical benefits of biochemical markers of bone turnover in Egyptian children with chronic liver diseases显示文摘AIM: To investigate the association between serum insulin-like growth factor 1 (IGF-1), osteocalcin, and parathyroid hormone (PTH) levels with the etiology and clinical condition of patients with chronic liver disease.METHODS: Eighty children with hepatocellular damage were divided into 3 groups according to the etiology of disease infection: bilharziasis (9 patients), hepatitis B virus (HBV, 12 patients) and hepatitis C virus (HCV, 29 patients). The Child score index was found as A in 24 patients, B in 22 patients, C in 4 patients. Thirty healthy children served as control group. HBsAg, HBcAbIgM, HBcAbIgG, and anti-HCV were detected using ELISA technique. HCV-RNA was measured by reverse transcription polymerase chain reaction (RT-PCR). Anti-bilharzial antibodies were detected by indirect haem- agglutination test. Liver function tests were performed using autoanalyser. Serum IGF-1, osteocalcin and PTH levels were measured by ELISA technique. Abdominal ultrasonography was also conducted.RESULTS: Serum IGF-1 level was significantly lower in all patient groups with liver diseases, while serum osteocalcin and PTH levels were significantly elevated in patients with HBV and HCV infections compared with the control group. Serum osteocalcin and PTH concentrations were measured with the severity of liver disease from Child A to C. Child A patients unexpectedly showed significantly reduced IGF-1 levels in comparison to patients staged as Child B or C. Serum osteocalcin level was negatively correlated with albumin (14.7 ± 0.54 vs 3.6 ± 0.10, P < 0.05), while that for PTH was positivelycorrelated with total protein (70.1 ± 2.17 vs 6.7 ± 0.10, P < 0.05) in patients with HCV infection.CONCLUSION: Low serum IGF-1 level seems to play a critical role in the bone loss in patients with chronic liver disease. Elevated biochemical markers of bone remodeling suggest high-turnover in patients with viral infection and reflect severity of the clinical stage. | Karam A Mahdy Hanaa H Ahmed Fathia Mannaa Azza Abdel-Shaheed | 2007 | World Journal of Gastroenterology2007，13，5： | 3 |
| 3 | A Comparison of Oven-cured and Induction-cured Adhesively Bonded Composite Joints显示文摘 | Mahdi S Kim H J Gama B A | 2003 | Journal of Composite Materials2003，37，6： | 1 |
| 4 | Peripartum roboticassisted laparoscopic hysterectomy after second-trimester pregnancy loss with placenta increta显示文摘 | Boes S Mahdi H Khoury F | 2013 | Obstet Gynecol2013，122，2： | 1 |
| 5 | Suicide in women with gynecologic cancer 显示文摘 | Mahdi H Swensen RE Munkarah AR | 2011 | Gynecol Oncol2011，122，2： | 1 |
| 6 | Production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involves de novo protein synthesis显示文摘 | MAHDY A M LOWES D A GALLEY H F | 2006 | Clin Vaccine Immunol2006，13，4： | 1 |
| 7 | Comparison of the Bishop score , ultrasonographically measured cervical length,and fetal fibronectin assay in predicting time until delivery and type of delivery at term显示文摘 | Patrick R Francois G Mahdie H | 2000 | Am J Obstet Gynecol2000，182，2： | 1 |
| 8 | hyperimmunoglobulinemia-E syndrome显示文摘 | Mahdi O Z Mathelier L L Al-Bardeisi N H | 2002 | Saudi Med J2002，23，4： | 1 |
| 9 | Optimal fixed gain linear proces-sing for amplify-and-forward multichannel relaying 显示文摘 | Dong M Mahdi H Liang B | 2012 | IEEETrans on Signal Processing <2012，60，11： | 1 |
| 10 | Structural and Magnetic Studies of Ga-doped Yttrium Iron Garnet显示文摘Ga-doped Yttrium Iron Garnet (Y_(3)Ga_(x)Fe_(5-x)O_(12),Ga:YIG) was prepared by solid state reaction method and sintering at 1 300 ℃.Rietveld analysis of X-ray diffraction patterns indicated that all samples crystallized in a single cubic structure (space group Ia-3d) with decreasing lattice constant as Ga concentration increased.SEM surface micrograph images of YIG samples showed highly compacted grains with small reduction in the grain size with increasing Ga concentration.Raman spectroscopy measurements confirmed the replacement of Fe^(3+) ions by Ga^(3+) ions in the garnet structure was revealed by the observed blue shifts in Raman spectra.The saturation magnetization decreased from 28.2 to 4.98 emu g^(-1) with increasing x from 0.0 to 1.0 due to the preferential substitution of Ga^(3+) ions for Fe^(3+) ions at tetrahedral sites.Room temperature Mössbauer spectra for the samples revealed a reduction of the hyperfine field values for octahedral and tetrahedral sites,and the development of additional components with increasing Ga concentration.Analysis of the magnetic data and Mössbauer spectra confirmed that spin canting in the substituted garnets plays an important role in explaining the observed reduction of the saturation magnetization as x increased. | Khozima Hamasha Qassem I Mohaidat Mahdi Lataifeh Ibrahim Bsoul Sami H Mahmood | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，1： | 1 |
| 11 | Solving flexible job shop sched- uling with multi objective approach显示文摘 | Arash M Kamyar S Mahdi H | 2010 | International Journal of Industrial Engineering & Production Research2010，21，4： | 1 |
| 12 | Surgical site iniection in women undergoing surgery for gynecologic cancer显示文摘 | Mahdi H Gojayev A Buechel M | 2014 | Int J Gynecol Cancer2014，24，4： | 1 |
| 13 | Differential modulation of interleukin-6 and interleukin-10 by diclofenac in patients undergoing major surgery 显示文摘 | Mahdy A M Galley H F Abdel-Wahed M A | 2002 | Br J Anaesth2002，88，6： | 1 |
| 14 | Nu- merical studies for fractional-order logistic differential e- quation with two different delays 显示文摘 | SWEILAM N H KHADER M M MAHDY A M S | 2012 | J Appl Math2012，76，： | 1 |
| 15 | Single-stage gain-clamped L-band EDFA with C-band ASE saturating tone 显示文摘 | Bakar A A A Mahdi M A AI-Mansoori M H | 2009 | Laser Physics2009，19，5： | 1 |
| 16 | Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator显示文摘 | Shariat-Madar Z Mahdi F Schmaier A H | 2002 | J Biol Chem2002，277，17： | 1 |
| 17 | Nu- merical studies for solving fractional-order logistic equa- tion显示文摘 | SWEILAM N H KHADER M M MAHDY A M S | 2012 | lnt J Pure Appl Math2012，78，： | 1 |
| 18 | An experimental study on shear strength of reinforced concrete beams with 100% recycled concrete aggregate 显示文摘 | Mahdi Arezoumandia Adam Smitha Jeffery S Volzb Kamal H Khayatc | 2014 | Construction and Building Materials2014，53，： | 1 |
| 19 | Effectiveness of Aloe vera on the anfioxidant status of different tissues in irradiated rats 显示文摘 | Saada H N Ussama Z S Mahdy A M | 2003 | Pharmazie2003，58，12： | 1 |
| 20 | Differential modulation of interleukin-6 and nterleukin-10 by diclofenac in patients undergoing major surgery显示文摘 | Mahdy A M Galley H F Abdel M A | 2002 | Br J Anaesth2002，88，6： | 1 |
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