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| 1 | Bevacizumab for the management of diabetic macular edema显示文摘Diabetic retinopathy (DR) is a leading cause of vision loss in the working-age population and is relatedto 1%-5% of cases of blindness worldwide. Diabetic macular edema (DME) is the most frequent cause of DR vision loss and is an important public health problem. Recent studies have implicated vascular endothelial growth factor (VEGF) in DR and DME pathogenesis, as well as provided evidence of the benefits of anti-VEGF agents for the management of such conditions. Despite the benefits of intravitreal ranibizumab injection for the management of DME, the cost-effectiveness of intravitreal bevacizumab therapy has gained increasing interest in the scientific community. This review summarizes the studies examining bevacizumab for the management of DME, focusing on the efficacy and duration of the clinical benefits of decreasing DME and the improvement of best-corrected visual acuity (BCVA). There is strong evidence that intravitreal bevacizumab injection therapy has a good cost-effective profile in the management of DME and may be associated with laser photocoagulation; however, its clinical superiority in terms of the duration of DME regression and the improvement of BCVA compared with intravitreal ranibizumab and other intravitreal anti-VEGF therapies remains unclear and deserves further investigation. | Francisco Rosa Stefanini J Fernando Arevalo Maurício Maia | 2013 | World Journal of Diabetes2013，4，2： | 18 |
| 2 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 3 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 4 | Tracheal lipoma mimicking obstructive lung disease显示文摘 | MOTA V T MAIA J G BARBOSA A T | 2010 | J Bras Pneumol2010，36，1： | 1 |
| 5 | The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis显示文摘 | Gonzalo Asensio J Maia C Ferrer NL | 2006 | Journal of Biological Chemistry:2006，281，3： | 1 |
| 6 | The transmissibility concept in multiple degrees of freedom systems 显示文摘 | Maia N M M Silva J M M Ribeiro A M R | 2001 | Mechanical Systems and Signal Processing2001，15，1： | 1 |
| 7 | Environmental behavior and analysis of veterinary and human drugs in soils,sediments and sludge显示文摘 | SILVIA D C MAIA J LOPEZ A | | 0，，06： | 1 |
| 8 | Sequentialinjection extraction based on restricted-access material fordetermination of furosemide in serum 显示文摘 | HUCLOVA J SATfNSKt D MAIA T | 2005 | J Chromatogr A2005，1087，12： | 1 |
| 9 | Blaming leaders for organizational accidents:proxy logic in collective-versus individual-agency cultures显示文摘 | Maia J Young | 2006 | Organizational Behavior and Human Decision Processes2006，，101： | 1 |
| 10 | Evolution of Peroxide-induced Thermomechanical Degradation of Polypropylene along the Extruder显示文摘 | A V Machado J M Maia S V Canevarolo | 2004 | J Appl Polym Sci2004，91，4： | 1 |
| 11 | Liver transplant for the treatment of giant hepatic hemangioma 显示文摘 | Ferraz AA Sette M J Maia M | 2004 | Liver Transpl2004，10，11： | 1 |
| 12 | Plant uncoupling mitochon-dria proteins显示文摘 | Vercesi A E Borecky J Maia I G | 2006 | Annu Rev Plant Biol2006，57，： | 1 |
| 13 | Damage detection using the frequency-response-function curvature method显示文摘 | Sampaio R P C Maia N M M Silva J M M | 1999 | Journal of Sound and Vibration1999，，5： | 1 |
| 14 | Experimental and modeling study of gas dispersion in a double turbine stirred tank显示文摘 | Alves S S Maia C I Vasconcelos J M T | 2002 | Chemical Engineering Science2002，57，： | 1 |
| 15 | Antipredatory secosterols from the octocoral Pseudopterogorgia americana显示文摘 | Epifanio R Maia L F Pawlik J R et a1 | 2007 | Mar Ecol Prog Ser2007，329，： | 1 |
| 16 | Rapid improvementof acute schizophrenia symptoms after intravenous sodium nitroprusside :a randomized,double - blind,placebo - controlled trial 显示文摘 | Hallak JE Maia - de - Oliveira JP Abrao J | 2013 | JAMAPsychiatry2013，70，7： | 1 |
| 17 | The attenuation of dysfunctional emotional processing with stimulant medication: an fMRI study of adolescents with ADHD显示文摘 | Posner J Maia TV Fair D Peterson BS Sonuga-Barke EJ Nagel BJ | 2011 | Psychiatry Res2011，193，3： | 1 |
| 18 | Longitudinal study in 3,000 m male runners:relationship between performance and selected physiological parameters显示文摘 | Bragada A Santos J Maia A | | 0，，09： | 1 |
| 19 | On the generalisation of the transmissibility concept显示文摘 | Ribeiro A M R Silva J M M Maia N M M | 2000 | Mechanical Systems and Signal Processing2000，14，1： | 1 |
| 20 | The transmissibility concept in mult degree-of freedom systems 显示文摘 | Maia N M Silva J M | 2001 | Mechanical Systems and Signal Processing2001，15，1： | 1 |
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