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| 1 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 2 | 在 polycystic 定义 bariatric 外科的角色卵巢的症候群病人显示文摘 Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women.To meet PCOS criteria,women must have a combination of hyperandrogenism,anovulation and ultrasound findings.Almost 10% of all reproductive age women worldwide show signs of PCOS.Although women often seek care for gynecological or body image concerns,many PCOS women are at risk for metabolic syndrome (MS).Many of the metabolic consequences are overlooked and un-dertreated by physicians because these patients tend to be young,reproductive age women.MS and obesity coexist commonly with PCOS.These young women are predisposed to glucose abnormalities and ulti-mately diabetes mellitus,dyslipidemia and eventually cardiovascular disease.Bariatric surgery can be an ef-fective means of weight loss in PCOS women.Surgical techniques have become safer and less invasive over time and have been found to be effective in achieving significant weight loss.Surgical options have also in-creased,giving patients more choices.Bariatric surgery may prevent or reverse metabolic syndrome.Bariatric surgery may also have reproductive benefits in PCOS patients.Although bariatric surgery has historically been performed in older,reproductive aged women,it has recently gained favor in adolescents as well.This is of particular importance due to the prevalence of both PCOS and MS in adolescents.Treatment of PCOS and MS certainly requires a combination of medical therapy,psychological support and lifestyle modifications.These treatments are difficult and often frustrating for pa-tients and physicians.Bariatric surgery can be effective in achieving significant weight loss,restoration of the hypothalamic pituitary axis,reduction of cardiovascular risk and even in improving pregnancy outcomes.Ulti-mately,bariatric surgery should be considered part of the treatment in PCOS women,especially in those with MS. | Shaveta M Malik Michael L Traub | 2012 | World Journal of Diabetes2012，3，4： | 12 |
| 3 | 长期食用含糖和人工甜味剂的饮料与美国成年人死亡风险的关系显示文摘摄入含糖饮料(sugar-sweetened beverages,SSB)或含人工甜味剂饮料(artificially sweetened beverages,ASB)是否与死亡风险相关,这关乎公共卫生利益。研究者分析了卫生专业人员随访研究(1986-2014年)中男性37 716人和护士健康研究(1980-2014年)中女性80 647人(基线无慢性病)的SSB和ASB的消费与总死亡率和病因特异性死亡率之间的关系。应用Cox比例风险回归估计风险比和95%CI。结果显示,在随访3415564人年期间,研究者记录了36436例死亡,其中心血管病死亡7896例,癌症死亡12380例。 | 刘青(译) 叶鹏(摘、审校) Malik VS Li Y Pan A De Koning L Schernhammer E Willett WC Hu FB | 2019 | 中华高血压杂志2019，27，5： | 9 |
| 4 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 5 | Phytoremediation of soil metals显示文摘 | Rufus L Chaney Minnie Malik Yin M Li Sally L Brown Eric P Brewer J Scott Angle Alan JM Baker | 1997 | Current Opinion in Biotechnology1997，，3： | 2 |
| 6 | In stent restenosis: more metal and more symmetry required 显示文摘 | Gunn J Malik N Shepherd L | 1997 | Heart1997，7，： | 2 |
| 7 | Primary total hipreplacement : a comparison of a nationally agreed guide to bestpractice and current sur- gical technique determined by the NorthWest Regional Arthroplasty Register显示文摘 | Malik MH Gambhir AK Bale L | 2004 | Ann R Coil Surg Engl2004，86，2： | 1 |
| 8 | Phytoremediation of soil metals显示文摘 | Chaney R L Malik K M Li Y M | 1997 | Cur Opin Biotechnol1997，8，2： | 1 |
| 9 | 显示文摘 | Jack L | 2000 | Journal of Immunological Methods2000，234，： | 1 |
| 10 | Phytoremediation of soil metals显示文摘 | Chaney R L Malik M Li Y M | 1997 | Current Opinions in Biotechnology1997，8，： | 1 |
| 11 | Phytoremediation of soil metals显示文摘 | Chaney R L Malik M Li Y M | 1997 | Current Opinions in Biotechnology1997，8，3： | 1 |
| 12 | The use of stereotactic radiosurgery in the management of meningiomas显示文摘 | Malik I Rowe JG Walton L | 2005 | Br J Neurosurg2005，19，1： | 1 |
| 13 | Sol-Gel Column Technology for Single-Step Deactivation, Coatong, and StationaryPhase Immobilization in High-Resolution Capillary Gas Chromatography显示文摘 | Chong S L Malik A | 1997 | Anal Chem1997，69，22： | 1 |
| 14 | Photoremediation of Soil Metals显示文摘 | Chaney P L Malik M Brown S L | 2002 | Current Opinion in Biotechnology2002，，8： | 1 |
| 15 | Vaginal prostaglandin(PGE2 and PGF2a)for induction of labour at term显示文摘 | KELLY A MALIK S SMITH L | 2009 | The Co-chrane Library2009，4，4： | 1 |
| 16 | Maternal morbidity and per- inatal outcome in preterm premature rupture of membranes before 37 weeks gestation显示文摘 | Dars S Malik S Samreen I et a l | 2014 | Pak J Med Sci2014，30，3： | 1 |
| 17 | Development of a scoring system for atrial fibrillation in acute stroke and transient ischemic attack patients:The LADS scoring system显示文摘 | Malik S Hicks WJ Schultz L | 2011 | J Neurol Sci2011，301，： | 1 |
| 18 | Raman studies of ZnO:Co thin films显示文摘 | ZHOU H CHEN L MALIK V KNIES C HOFMANN D M | | 0，，01： | 1 |
| 19 | The lncRNA PCAT29 inhibits oncogenic phenotypes in prostate cancer显示文摘 | MALIK R PATEL L PRENSNER J R | 2014 | Mol Cancer Res2014，12，8： | 1 |
| 20 | Phase Ⅱ study of weekly docetaxel alone or in combination with trastuzumab in patients with metastatic breast cancer显示文摘 | Raff JP Rajdev L Malik U | 2004 | Clin Breast Cancer2004，4，： | 1 |
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