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| 1 | Pyruvate-fortified resuscitation stabilizes cardiac electrical activity and energy metabolism during hypovolemia显示文摘AIM: To test the hypothesis that fluid resuscitation with Ringer's solution enriched with pyruvate(PR), a physiological antioxidant and energy substrate, affords protection of myocardial metabolism and electrophysiological performance superior to lactated Ringer's(LR) during hypovolemia and hindlimb ischemia-reperfusion.METHODS: Male domestic goats(25-30 kg) were exsanguinated to a mean arterial pressure of 48 ± 1 mm Hg. Right hindlimb ischemia was imposed for 90 min by applying a tourniquet and femoral crossclamp. LR or PR, infused iv, delivered 0.05 mmol/kg per minute L-lactate or pyruvate, respectively, from 30 min hindlimb ischemia until 30 min post-ischemia. Time controls(TC) underwent neither hemorrhage, hindlimb ischemia nor resuscitation. Goats were sacrificed and left ventricular myocardium biopsied at 90 min fluid resuscitation(n = 6 per group) or 3.5 h later(n = 9 LR, 10 PR, 8 TC).RESULTS: Myocardial 8-isoprostane content, phosphocreatine phosphorylation potential, creatine kinase activity, and heart rate-adjusted QT interval(QTc) vari- ability were evaluated at 90 min resuscitation and 3.5 h post-resuscitation. PR sharply lowered pro-arrhythmic QTc variability vs LR(P < 0.05); this effect persisted 3.5 h post-resuscitation. PR lowered myocardial 8-isoprostane content, a product of oxidative stress, by 39 and 37% during and 3.5 h after resuscitation, respectively, vs LR. Creatine kinase activity fell 42% post-LR vs TC(P < 0.05), but was stable post-PR(P < 0.02 vs post-LR). PR doubled phosphocreatine phosphorylation potential, a measure of ATP free energy state, vs TC and LR(P < 0.05); this energetic enhancement persisted 3.5 h post-resuscitation.CONCLUSION: By augmenting myocardial energy state and protecting creatine kinase activity, pyruvateenriched resuscitation stabilized cardiac electrical function during central hypovolemia and hindlimb ischemiareperfusion. | Hunaid A Gurji Daniel W White Besim Hoxha Jie Sun Albert H Olivencia-Yurvati Robert T Mallet | 2013 | World Journal of Critical Care Medicine2013，2，4： | 3 |
| 2 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 3 | Treatment of HBV-related cirrhosis 显示文摘 | VALLER-PICHARD A MALLET V COSTENTIN CE et ~d | 2009 | Expert Rev Anti Infect Ther2009，7，8： | 1 |
| 4 | Current Zika virus epide miology and recent epidemics 显示文摘 | Ioos S Mallet HP Leparc Goffart I et a| | 2014 | Med Mal Infect2014，44，7： | 1 |
| 5 | Treatment of HBV-related cirrhosis 显示文摘 | Vallet-Pichard A Mallet V Costentin CE | 2009 | Expert Rev Anti Infect Ther2009，7，5： | 1 |
| 6 | Autonomous rover navigation on unknown terrains:Functions and Integration显示文摘 | Lacroix S Mallet A Bonnafous D | | 0，，10： | 1 |
| 7 | Dual role for pilus in adherence to epithelial cells and hiofilm formation in Streptococ- cus agalactiae显示文摘 | Konto - Ghiorghi Y Mairey E Mallet A | 2009 | PLoS Pathog2009，5，10： | 1 |
| 8 | New industrial polymers显示文摘 | Mallet M A J | 1974 | ACS Symp Ser1974，，4： | 1 |
| 9 | Coadministration of gatifloxacin and multivitamin preparation containing minerals:potential treatment failure in an elderly patient显示文摘 | Mallet L Huang A | 2005 | Ann Pharmacother2005，39，1： | 1 |
| 10 | The Temperament and Character Inventory - Revised (TCI - R) : psychometric characteris- tics of the French version 显示文摘 | Pelissolo A Mallet L Baleyte J - M | 2005 | Acta Psychiatr Seand2005，112，： | 1 |
| 11 | General and specific combining abilities of larval and juvenile growth and viability estimated from natural oyster populations显示文摘 | Mallet A L Halev L E | 1984 | Marine Biology1984，81，1： | 1 |
| 12 | Growth rate and survival in pure population matings and crosses of the oyster Crassostrea virginica 显示文摘 | Mallet A L Haley L E | 1983 | Can J Fish Aquat Sci1983，40，： | 1 |
| 13 | Overexpression of ba- sic helix-loop-helix transcription factors enhances neuronal differentiation of fetal human neural progenitor cells in vari- ous ways显示文摘 | Serre A Snyder EY Mallet J | 2012 | Stem Ceils Dev2012，21，4： | 1 |
| 14 | Influence of starchs of low digestibility on the rat caecal microfloar显示文摘 | MALLET A K BEARNE C A YOUNG P J | 1988 | Br J Nutr1988，60，3： | 1 |
| 15 | Determinants of paradoxical CD4 cell reconstitution after protease inhibi- tor-containing antiretroviral regimen显示文摘 | Renaud M Katlama C Mallet A | 1999 | AIDS1999，13，6： | 1 |
| 16 | Estimating the carrying capacity of a coastal in let for mussel culture 显示文摘 | Carver C E Mallet A L | 1990 | Aquaculture1990，88，： | 1 |
| 17 | Treatment of HBV- related cirrhosis显示文摘 | Vallet-Pichard A Mallet V Costentin CE | 2009 | Expert Rev Anti Infect Ther2009，7，： | 1 |
| 18 | Dual role for pilus in adherence to epithelial cells and biofilm formation in Streptococcus agalactiae显示文摘 | Konto-Ghiorghi Y Mairey E Mallet A | 2009 | PLoS pathogens2009，5，10： | 1 |
| 19 | Expression of interleukin-18 in human at heroscleretic plaques and relation to plaque instability 显示文摘 | Mallet Z Corbaz A Scoazec A | 2001 | Circulation2001，104，14： | 1 |
| 20 | Ensemble of SVMs for improving brain computer interface P300 speller performances 显示文摘 | RAKOTOMAMONJY A GUIGUE V MALLET G | 2005 | Lecture Notes in Computer Science2005，3696，： | 1 |
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