|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 2 | The spouse:a factor in recovery after acute myocardial infarction显示文摘 | Beach E K Maloney B H Plocica A R | 1992 | Heart Lung1992，21，1： | 1 |
| 3 | Pre - B - cell colo- ny - enhancing factor as a potential novel biomarker in acute lung in- jury显示文摘 | YE S Q SIMON B A MALONEY J P | 2005 | Am J Respir Crit Care Med2005，171，4： | 1 |
| 4 | Rituximab: mechanism of action and resistance 显示文摘 | Maloney D G Smith B Rose A | 2002 | Semin Oncol2002，29，12： | 1 |
| 5 | Pre-B-cell colony-enhancing factor as a potential novelbiomarker in acute lung injury 显示文摘 | YE S Q SIMON B A MALONEY J P | 2005 | Am J RespirCrit Care Med2005，171，4： | 1 |
| 6 | Diagnostic chal- lenge of artifactual electrocardiographic tachya- rrhythmias显示文摘 | Barold SS Maloney JD Herweg B | 2013 | Cardiol J2013，20，1： | 1 |
| 7 | Thermal network predictions of the daily temperature fluctuations in a direct gain room 显示文摘 | Maloney J Wang T Chen B | 1982 | Solar Energy1982，29，3： | 1 |
| 8 | Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury显示文摘 | Ye S Q Simon B A Maloney J P | 2005 | Am J Respir Crit Care Med2005，171，4： | 1 |
| 9 | Gene structure and organization of the human β-secretase ( BACE ) promoter 显示文摘 | Sambamurti K Kinsey R Maloney B | 2004 | FASEB J2004，18，9： | 1 |
| 10 | Development and validation of the high-quality'rapid method for swab' to genotype the HT-TLPR serotonin transporter(SLC6A4)promoter polymorphism显示文摘 | Maloney B Ray B Hayden EP | | 0，，02： | 1 |
| 11 | Rimximab: Mechanism of action and resistance 显示文摘 | Maloney DG Smith B Rose A | 2002 | Semin Oncol2002，，112： | 1 |
| 12 | Computer-as- sisted instruction in clinical education: a roadmap to incr- easing CAI implementation 显示文摘 | Berman N B Fall L H Maloney C G | 2008 | Adv Health Sci Educ Theory Pract2008，13，3： | 1 |
| 13 | How to adjust media recommendations on reporting suicidal behavior to new media developments 显示文摘 | Maloney J Pfuhlmann B Arensman E | 2014 | Arch Suicide Res2014，18，2： | 1 |
| 14 | Color constancy:a method for recovering surface spectral reflectance显示文摘 | MALONEY L T WANDELL B A | 1986 | Journal of the Optical Society of America1986，3，1： | 1 |
| 15 | Professionalization of attitude to- ward play among Canadian school pupils as a function of sex, grade, and athletic participation 显示文摘 | Maloney T L Petrie B | 1972 | Journal of Leis- ure Research1972，，4： | 1 |
| 16 | Differential c-Fos expression in cholinergic,mono-aminergic,and GABAergic cell groups of the pontomesencephalic tegmentum after paradoxical sleep deprivation and recovery显示文摘 | MALONEY K J MAINVILLE L JONES B E | 1999 | Neurosci1999，19，8： | 1 |
| 17 | Effects of wearing compression garments on thermoregulation during simulated team sport activity in temperate environmental conditions 显示文摘 | HOUGHTON L A DAWSON B MALONEY S K | 2009 | J Science Med Sport2009，12，2： | 1 |
| 18 | Metabolic abnormalities associated with calyceal diverticular stones显示文摘 | Auge BK Maloney M E Mathias B J | 2006 | BJU Int2006，，97： | 1 |
| 19 | Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene显示文摘 | Bellingham SA Lahiri DK Maloney B | 2004 | J Biol Chem2004，279，20： | 1 |
| 20 | Metabol- ic abnormalities associated with calyceal diverticular stones显示文摘 | Auge B K Maloney M E Mathias B J | 2006 | Br J Urol2006，97，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员