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| 1 | Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin显示文摘瞄准:Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物,但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法:在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) , hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后,胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果:HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外,在 GSH 层次的差别都没被检测。结论:不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环,在类脂化合物的没有差别每氧化,产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。 | Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 2 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 3 | Use of nerve blocks for botulinum toxin treatment of palmar-plantar hyperhidrosis显示文摘 | Fujita M Mann T Mann O | 2001 | J Am Acad Dermatol2001，45，： | 2 |
| 4 | Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha synuelein: Implication for alpha-synueleinopathies显示文摘 | ISHII A NONAKA T TANIGUCHI S SAOTO T ARAI T MANN D IWATSUBO T HISANAQA S GOEDERT M HASEQAWA M | 2007 | FEBS Lett2007，581，24： | 1 |
| 5 | Observed and simulated muhidecadal variability in the Northern Hemisphere显示文摘 | DELWORTH T L MANN M E | 2000 | Climate Dynamics2000，16，9： | 1 |
| 6 | Variable Zinc coordination in endostatin显示文摘 | Hohenester E Sasaki T Mann K | 2000 | J Mol Biol2000，297，1： | 1 |
| 7 | Immunohistochemically detected micrometastases of the lymph modes in patients with gastric carcinoma显示文摘 | Fukagawa T Sasako M Mann GB | 2003 | Cancer 20032003，92，4： | 1 |
| 8 | Maternal cell contamination of prenatal samples assessed by QF-PCR genotypeing显示文摘 | STOJILKOVIC-MIKIC T MANN K | 2005 | Prenatal Diagnosis2005，25，1： | 1 |
| 9 | Performance of floating and sunken media biological aerated filters under unsteady state conditions显示文摘 | Mann A T Mendoza-Espinosa L Stephenson T | 1999 | Water Research1999，33，4： | 1 |
| 10 | 4-n-butylresorcinol, a highly ef- fective lyrosinase inhibitor for the topical treatment of hyperpigmen- tation 显示文摘 | Kolbe L Mann T Gerwat W | 2013 | Journal of the European Academy of Dermatology and Venereology2013，27，1： | 1 |
| 11 | Characterization of the inhibition of hepatitis C virus entry by in vitro-generated and patient-derived oxidized low-density lipoprotein显示文摘 | Westhaus S Bankwitz D Ernst S Rohrmann K Wappler I AgnéC Luchtefeld M Schieffer B Sarrazin C Manns M P Pietschmann T Ciesek S von Hahn T | 2013 | Hepatology2013，57，5： | 1 |
| 12 | Expression of HLA class I molecules and transporter axxociated with antigen processing in hepatocelluler carcinoma 显示文摘 | Carrington D L Mann T B | 1996 | Hepatology1996，23，： | 1 |
| 13 | High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes显示文摘 | Finckh U Muller-Thomsen T Mann U | 2000 | Am J Hum Genet2000，66，： | 1 |
| 14 | Peroxidative breskdown of phospholipids in human spermatozoa, spermicidal property of fatty acid peroxides, and protective action of seminal plasma显示文摘 | JONES R MANN T SHERINS R | 1997 | Fertil Steril1997，31，7： | 1 |
| 15 | Bioinorganic clays: synthesis and characterization of amino and polyamino acid intercalated layered double hydroxides 显示文摘 | WHILTON N T VICKERS P J MANN S | 1997 | J Mater Chem1997，7，8： | 1 |
| 16 | The regulation of the factor Ⅷ-dependent coagulation pathway: rationale for the effectiveness of recombinant factor Ⅶ a in refractory bleeding disorders 显示文摘 | van 't Veer C Mann KG | 2000 | Semin Thromb Hemost2000，26，： | 1 |
| 17 | Application of the mobile metal ion technique to routine geochemical exploration 显示文摘 | Mann A W Birrell R D Mann A T | 1998 | Journal of Geochemical Exploration1998，61，： | 1 |
| 18 | A central role of salicylic acid in plant disease resistance显示文摘 | DELANEY T P UKNES S VERNOOIJ B FRIEDRICH L WER- MANN K NEGROTYO D GAFFNEY T GUT-RELLA M KESS- MANN H WARD E RYALS J | 1994 | Science1994，266，5188： | 1 |
| 19 | Influence of static and dy- namic load on porosity of eonerete显示文摘 | J]ANG F X WITI'MANN F H ZHAO T | 2011 | Restoration of Buildings and Monuments2011，17，34： | 1 |
| 20 | Pre- and posts- ynaptic twists in BDNF secretion and action in synaptic plasticity显示文摘 | Edelmann E L@mann V Brigadski T | 2013 | Neuropharmaeology2013，13，： | 1 |
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