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| 1 | Biomarkers for pancreatic cancer:Recent achievements in proteomics and genomics through classical and multivariate statistical methods显示文摘Pancreatic cancer(PC) is one of the most aggressive and lethal neoplastic diseases. A valid alternative to the usual invasive diagnostic tools would certainly be the determination of biomarkers in peripheral fluids to provide less invasive tools for early diagnosis. Nowadays, biomarkers are generally investigated mainly in peripheral blood and tissues through high-throughput omics techniques comparing control vs pathological samples. The results can be evaluated by two main strategies:(1) classical methods in which the identification of significant biomarkers is accomplished by monovariate statistical tests where each biomarker is considered as independent from the others; and(2) multivariate methods, taking into consideration the correlations existing among the biomarkers themselves. This last approach is very powerful since it allows the identification of pools of biomarkers with diagnostic and prognostic performances which are superior to single markers in terms of sensitivity, specificity and robustness. Multivariate techniques are usually applied with variable selection procedures to provide a restricted set of biomarkers with the best predictive ability; however, standard selection methods are usually aimed at the identification of the smallest set of variables with the best predictive ability and exhaustivity is usually neglected. The exhaustive search for biomarkers is instead an important alternative to standard variable selection since it can provide information about the etiology of the pathology by producing a comprehensive set of markers. In this review, the most recent applications of the omics techniques(proteomics, genomics and metabolomics) to the identification of exploratory biomarkers for PC will be presented with particular regard to the statistical methods adopted for their identification. The basic theory related to classical and multivariate methods for identification of biomarkers is presented and then, the most recent applications in this field are discussed. | Emilio Marengo Elisa Robotti | 2014 | World Journal of Gastroenterology2014，20，37： | 5 |
| 2 | Wearable multifunctional printed graphene sensors显示文摘The outstanding properties of graphene have initiated myriads of research and development;yet, its economic impact is hamperedby the difficulties encountered in production and practical application. Recently discovered laser-induced graphene is generated bya simple printing process on flexible and lightweight polyimide films. Exploiting the electrical features and mechanical pliability ofLIG on polyimide, we developed wearable resistive bending sensors that pave the way for many cost-effective measurementsystems. The versatile sensors we describe can be utilized in a wide range of configurations, including measurement of force,deflection, and curvature. The deflection induced by different forces and speeds is effectively sensed through a resistancemeasurement, exploiting the piezoresistance of the printed graphene electrodes. The LIG sensors possess an outstanding range forstrain measurements reaching >10% A double-sided electrode concept was developed by printing the same electrodes on bothsides of the film and employing difference measurements. This provided a large bidirectional bending response combined withtemperature compensation. Versatility in geometry and a simple fabrication process enable the detection of a wide range of flowspeeds, forces, and deflections. The sensor response can be easily tuned by geometrical parameters of the bending sensors and theLIG electrodes. As a wearable device, LIG bending sensors were used for tracking body movements. For underwater operation,PDMS-coated LIG bending sensors were integrated with ultra-low power aquatic tags and utilized in underwater animal speedmonitoring applications, and a recording of the surface current velocity on a coral reef in the Red Sea. | Altynay Kaidarova Mohammed Asadullah Khan Marco Marengo Liam Swanepoel Alexander Przybysz Cobus Muller Andreas Fahlman Ulrich Buttner Nathan R.Geraldi Rory P.Wilson Carlos M.Duarte Jurgen Kosel | 2019 | npj Flexible Electronics2019，3，1： | 2 |
| 3 | Prediction of HPLC retention times in gradient elution from isocratic data application to a set of non-homologous compounds and different stationary phases显示文摘 | E. Marengo C. Baiocchi M. C. Gennaro P. Bertolo | 1989 | Chromatographia (-)1989，，1： | 2 |
| 4 | Proteomic changes involved in tenderization of bovine Longissimus dorsi muscle during prolonged ageing显示文摘 | Rita Polati Michele Menini Elisa Robotti Renato Millioni Emilio Marengo Enrico Novelli Stefania Balzan Daniela Cecconi | 2012 | Food Chemistry2012，，3： | 2 |
| 5 | The response of honey- comb sandwich panels under low-velocity impact loading 显示文摘 | Meo M Vignjevic R Marengo G | 2005 | Int J Mechan Sci2005，47，9： | 1 |
| 6 | Epilepsy-induced changes in signaling systems of human and rat postsynaptie densities显示文摘 | Wyneken U Marengo J J Villanueva S | 2003 | Epilepsia2003，44，2： | 1 |
| 7 | Epilepsy-indueed changes in signaling systems of human and rat postsynaptic densities 显示文摘 | Wyneken U Marengo J J Villanueva S | 2003 | Epilepsia2003，44，2： | 1 |
| 8 | Risk management of renal biopsy:1387 cases over 30 years in a single centre显示文摘 | Canavese C Marengo M | 2007 | Eur J Clin Invest2007，37，12： | 1 |
| 9 | Cardiovascular effects of tibolone: a selective tissue estrogenic activity regulator显示文摘 | Campisi R Marengo FD | 2007 | Cardiovasc Drug Rev2007，25，2： | 1 |
| 10 | Numerical simulations of low-velocity impact on an aircraft sandwich panel显示文摘 | Meo M Morris A J Vignjevic R Marengo G | 2003 | Composite Structures2003，62，： | 1 |
| 11 | Root reinforcement effect of different grass species: a comparison between experimental and models results显示文摘 | COMINO E MARENGO P ROLLI V | 2010 | Soil & Tillage Research2010，110，： | 1 |
| 12 | Constitutive activation of PI3K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model显示文摘 | Shukla S Maclennan GT Marengo SR | 2005 | Prostate2005，64，3： | 1 |
| 13 | Classification of Nebbiolo-based wines from Piedmont(Italy)by means of solid-phase microextraction-gas chromatography-mass spectrometry of volatile compounds显示文摘 | Marengo E Aceto M Maurino V | | 0，，01： | 1 |
| 14 | The role of time in single drop splash on thin film显示文摘 | G. E. Cossali M. Marengo A. Coghe S. Zhdanov | 2004 | Experiments in Fluids2004，，6： | 1 |
| 15 | Time reversal MUSIC image of extended targets 显示文摘 | MARENGO E A GRUBERF K SIMONETTI F | 2007 | IEEE Transactions on Image Processing2007，16，8： | 1 |
| 16 | The impact of a single drop on a wetted solid surface显示文摘 | COSSALI G E COGHE A MARENGO M | 1997 | Experiments in Flu- ids1997，22，6： | 1 |
| 17 | The impact of a single drop on a wetted solid surface显示文摘 | G. E. Cossali A. Coghe M. Marengo | 1997 | Experiments in Fluids1997，，6： | 1 |
| 18 | Statistical investigation of the differences in the distribution of metals in Nebbiolo- based wines显示文摘 | Marengo E Aceto M | 2003 | Food Chemistry2003，81，： | 1 |
| 19 | Decreased renal expression of the putative calcium oxalate inhibitor Tamm- Horsfall protein in the ethylene glycol rat model of calcium oxalate urolithiasis显示文摘 | Marengo S R Chen D H Kaung H L | 2002 | J Urol2002，167，5： | 1 |
| 20 | The response of honeycomb sandwich panels under low-velochy impact loading 显示文摘 | MEOA M VIGNJEVICA R MARENGO G | 2005 | International Journal of Mechanical Sciences2005，47，： | 1 |
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