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| 1 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 2 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 3 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 4 | Molecular biology and regulation of abscisic acid biosynthesis in plants显示文摘 | Liotenberg S North H Marion P A | 1999 | Plant Physiology and Biochemistry1999，299，： | 1 |
| 5 | 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial显示文摘 | Ian Smith Marion Procter Richard D Gelber Sébastien Guillaume Andrea Feyereislova Mitch Dowsett Aron Goldhirsch Michael Untch Gabriella Mariani Jose Baselga Manfred Kaufmann David Cameron Richard Bell Jonas Bergh Robert Coleman Andrew Wardley Nadia Harbec | 2007 | The Lancet2007，，9555： | 1 |
| 6 | Search for variations of fun- damental constants using atomic tountain clocks显示文摘 | Marion H Pereira D S F Abgrall M | 2003 | Physical Review Letters2003，90，15： | 1 |
| 7 | Enanti-oselective electrodes:stereose-lective el-ectroreduction of 4-methylbenzopheno-ne and a-cetophenone 显示文摘 | Marion S Susanne P Carl H H | 1999 | Journal of E-lectroanalytical Chemistry1999，461，： | 1 |
| 8 | A betaarrestin 2 signaling complex mediates lithium action on behavior显示文摘 | Beaulieu J M Marion S Rodriguiz R M | 2008 | Cell2008，132，1： | 1 |
| 9 | Real-time reverse transcription PCR analysis of expression of atrazine catabolism genes in two bacterial strains isolated from soil 显示文摘 | Marion D Guy S Fabrice M L | 2004 | Journal of Microbiological Methods2004，56，1： | 1 |
| 10 | Transit-Oriented Development in San Diego County: The Incremental Implemental of A Planning Idea显示文摘 | Marion G Boarnet T Nicholas S | 1999 | Journal of the American Planning Association1999，65，1： | 1 |
| 11 | The LatrorefStudy: Med- ical Errors are Associated with ,Symptoms of Depression in ICU Staff but not Burnout or Safety Culture 显示文摘 | Maite GO Marion P Lilia S | 2015 | Intensive Care Medicine2015，41，2： | 1 |
| 12 | An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior 显示文摘 | Beaulieu JM Sotnikova TD Marion S | 2005 | Cell2005，122，2： | 1 |
| 13 | A microsatellite map of wheat 显示文摘 | Marion S Roder Victor Korzun | 1998 | Genetics1998，149，： | 1 |
| 14 | The ERK-dependent signalling is stage specifically modulated by FSH,during primary Sertoli cell maturation显示文摘 | Crepieux P Marion S Martinat N | 2001 | Oncogene2001，20，： | 1 |
| 15 | Intestinal uptake and biliary ex- cretion of the isoflavone genistein in rats 显示文摘 | Jeff S Lori C Marion K | 1997 | J Nutr1997，127，7： | 1 |
| 16 | Treatment of traumatic brain injury with moderate hypothermia 显示文摘 | MARION D W PENROD L E KELSEY S F | 1997 | N Engl J Med1997，336，8： | 1 |
| 17 | Assessment of abstracts submitted to the annual scientific meeting of the Royal Australian and New Zealand College of Radiologists显示文摘 | Marion K Taylor M | 2006 | Australian Radiology2006，，50： | 1 |
| 18 | Cellular adhesion of primary Sertoli cells affects responsiveness of the extracellular signal-regulated kinases 1 and 2 to follicle-stimulating hormone but not to epidermal growth factor显示文摘 | Crepieux P Martinat N Marion S | 2002 | Archives of Biochemistry and Biophysics2002，399，： | 1 |
| 19 | An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior显示文摘 | Beaulieu J M Sotnikova T D Marion S | 2005 | Cell2005，122，2： | 1 |
| 20 | Sunitinib inhibits MEK/ERK and SAPK/JNK pathways and increases sodium/Io- dide symporter expression in papillary thyroid cancer显示文摘 | Fenton M S Marion K M Salem A K | 2010 | Thy roid2010，20，9： | 1 |
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