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| 1 | Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer:An update显示文摘The biosynthesis of prostanoids is involved in both physiological and pathological processes. The expression of prostaglandin-endoperoxide synthase 2(PTGS2; also known as COX-2) has been traditionally associated to the onset of several pathologies, from inflammation to cardiovascular, gastrointestinal and oncologic events. For this reason, the search of selective PTGS2 inhibitors has been a focus for therapeutic interventions. In addition to the classic non-steroidal anti-inflammatory drugs, selective and specific PTGS2 inhibitors, termed coxibs, have been generated and widely used. PTGS2 activity is less restrictive in terms of substrate specificity than the homeostatic counterpart PTGS1, and it accounts for the elevated prostanoid synthesis that accompanies several pathologies. The main regulation of PTGS2 occurs at the transcription level. In addition to this, the stability of the mRNA is finely regulated through the interaction with several cytoplasmic elements, ranging from specificmicroR NAs to proteins that control mR NA degradation. Moreover, the protein has been recognized to be the substrate for several post-translational modifications that affect both the enzyme activity and the targeting for degradation via proteasomal and non-proteasomal mechanisms. Among these modifications, phosphorylation, glycosylation and covalent modifications by reactive lipidic intermediates and by free radicals associated to the proinflammatory condition appear to be the main changes. Identification of these post-translational modifications is relevant to better understand the role of PTGS2 in several pathologies and to establish a correct analysis of the potential function of this protein in diseases progress. Finally, these modifications can be used as biomarkers to establish correlations with other parameters, including the immunomodulation dependent on molecular pathological epidemiology determinants, which may provide a better frame for potential therapeutic interventions. | Rafael I Jaén Patricia Prieto Marta Casado Paloma Martín-Sanz Lisardo Boscá | 2018 | World Journal of Gastroenterology2018，24，48： | 5 |
| 2 | The AP-3 adaptor complex is required for vacuolar function in Arabidopsis显示文摘Subcellular trafficking 在真核细胞的房间为大量的功能被要求。它包含货物排序,在多重层次的泡形成, trafficking 和熔化过程的规定。适配器蛋白质(AP ) 建筑群是货物在酵母和哺乳动物排序进泡的关键管理者,但是他们在植物的存在和功能没被表明。这里,我们报导影响蛋白质的 trafficking 的鉴定 4 (pat4 ) 在通常认为的 δ 的变异的有缺陷者;AP-3 建筑群的子单元。pat4 和 pat2,从缺乏功能的通常认为的 AP-3 β 的一样的 GFP 基于成像的向前基因的屏幕孤立的异种;,以及主导的否定 AP-3 μ难辨别的显型由大部分正常的形态学和开发描绘了的转基因的线显示,而是在异常 vacuolar 结构的膜蛋白质的强壮的细胞内部的累积。所有异种在形态学和功能是有缺点的 lysin 并且蛋白质存储液泡(PSV ) 但是储备蛋白质排序到 PSV 的表演正常。Immunoprecipitation 实验和基因研究揭示了通常认为的 AP-3 β 的紧密的功能、物理的协会;并且 AP-3 δ子单元。而且,两蛋白质仔细与通常认为的 AP-3 μ 被连接;并且 σ子单元和 clathrin 和 dynamin 机械的几个部件。一起拿,这些结果表明那 AP 建筑群,类似于那些在另外的优核质,在植物,和那 AP-3 存在在植物房间在生物的续生说的规定和液泡的功能起一个特定的作用。 | Marta Zwiewka Elena Feraru Barbara Moller Inhwan Hwang Mugurel I Feraru Jargen Kleine-Vehn Dolf Weijers Jifi Friml | 2011 | Cell Research2011，21，12： | 3 |
| 3 | Electro-tribological properties of diamond like carbon coatings显示文摘Diamond like carbon(DLC)coatings typically present good self-lubricating tribological properties that could be of interest in sliding dielectric contacts in multiple electrical applications.In this work electro-tribological studies have been performed on several DLC coatings against aluminum in different humidity conditions,in which the coefficients of friction(CoFs)and electrical contact resistance(ECR)were continuously monitored.Results show that CoF and ECR data can be linked to the properties of the coatings(thickness,finishing,microstructure,residual stresses,and wettability)and the degradation modes of their tribological and electrical properties.Therefore,electro-tribological data can provide valuable information about the performance of dielectric coatings,the reasons behind it,and assist in the development of the coatings.ECR also shows potential for on-line monitoring of coated parts in operation. | Iñigo BRACERAS Iñigo IBÁNEZ Santiago DOMINGUEZ-MEISTER Xabier VELASCO Marta BRIZUELA Iñaki GARMENDIA | 2020 | Friction2020，8，2： | 2 |
| 4 | Nested PCR improves detection of infectious hematopoietic necrosis virus in cells coinfected with infectious pancreatic necrosis virus显示文摘 | Marta Alonso Sylvia Rodr??guez Sara I Pérez Prieto | 1999 | Journal of Virological Methods1999，，1： | 2 |
| 5 | Optical spectroscopy of lanthanide ions in Al2O3-Nb2O5-TeO2 glasses显示文摘 | Marta Z Adolfo S Gianluigi I | 2004 | Optical Materials2004，25，2： | 1 |
| 6 | Heterogeneous photocatalysis transition metal ions in photocatalytic systems 显示文摘 | Marta I L | 1999 | Appl Catal B: Environ1999，23，： | 1 |
| 7 | Experimental evidence in favor of an initial one-electron-transfer process in the heterogeneous photoca- talytic reduction of chromium( VI ) over TiO2显示文摘 | Testa J J Grela M A Marta I | 2001 | Langmuir2001，17，12： | 1 |
| 8 | Cereal arabinoxylans:advances in struc-ture and physicochemical properties显示文摘 | Marta S I Costas G B | 1995 | Carbohydrate Polymers1995，28，： | 1 |
| 9 | Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment显示文摘 | Sainz Bruno Alcala Sonia Garcia Elena Sanchez-Ripoll Yolanda Azevedo Maria M Cioffi Michele Tatari Marianthi Miranda-Lorenzo Irene Hidalgo Manuel Gomez-Lopez Gonzalo Can?amero Marta Erkan Mert Kleeff Jorg Garcn?i?a-Silva Susana Sancho Patricia Hermann Pat | 2015 | Gut2015，，12： | 1 |
| 10 | Characterization of poly ( dimethylsiloxane ) -poly ( methylhydrogen siloxane ) composite membranes for organic water pervaporation separation 显示文摘 | Marta O G Alicia I C Isabel A M | 2001 | Journal of Applied Polymer Science2001，81，： | 1 |
| 11 | Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases 显示文摘 | Marta Sobczak Pitor K Zakrzewski Adam I Cygankiewicz | 2014 | Pharmacol Rep2014，66，5： | 1 |
| 12 | Heterogeneous photocatalysis:transition metal ions in photocatalytic system 显示文摘 | Marta I L | 1999 | Appl Catal B1999，23，2： | 1 |
| 13 | New cytotoxic indolic metabolites from a marine Streptomyces显示文摘 | Jose S L Marta M I Julia P B | 2003 | J Nat Prod2003，66，： | 1 |
| 14 | The role of motivation in visitor satisfaction: Empirical evidence in rural tourism显示文摘 | Devesa Mar i a Laguna Marta Andr 6 s Palacios | 2010 | Tourism Management2010，4，31： | 1 |
| 15 | Recent debris flow occurrences associated with glaciers in the Alps 显示文摘 | Marta C Sara I Giovanni M | 2007 | Global and Planetary Change2007，56，： | 1 |
| 16 | Physiological responses of the seagrass Posidonia oceanica to elevated organic matter content in sediments:An experimental assessment显示文摘 | MARTA P OLGA I JUAN M R | | 0，，02： | 1 |
| 17 | Heterogeneous photocatalysis transition metal ions in photocatalytic systems 显示文摘 | Marta I L | 1999 | Applied Catalysis B1999，23，23： | 1 |
| 18 | Heterogeneous photocatalysis transition metal ions in photocatalytic system显示文摘 | Marta I L | 1999 | Appl Catal B1999，23，： | 1 |
| 19 | BDNF Up - Regulates TrkB Pro- tein and Prevents the Death of CA1 Neurons Following Transient Fore- brain Ischemia 显示文摘 | Ferret I Ballabriga J Marta E | 1998 | Brain pathology1998，8，2： | 1 |
| 20 | Isolation,structural features and rheological properties of water-extractable β-glucans from different Greek barley cultivars显示文摘 | Maria I Costas G B Marta S I | 2004 | Journal of the Science of Food and Agriculture2004，84，： | 1 |
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