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| 1 | Mouse embryos cloned from brain tumors显示文摘Cancer cells escape from growth cont rol by accumulating genetic and epig enetic alterations.In rare instances,epigenetic changes alone are oncogenic.Furthermore,a gents that modify DNA methylation or chromatin structure can restore a normal phenotype to cells harboring oncogenic mutations.How ever,it is unclear to what extent epi genetic reprogramming can reverse o ncogenesis.Using somatic nuclear transfer,we show that medul loblastomas arising in Ptc1+/-mice can direct preimplantation develop ment.Additionally,blastocysts derived from medullobl astoma nuclei form postimplantatio n embryos with typical cell layers.T hus,tumor cells can be epigenetically reprogrammed into n ormal cell types.This approach coul d lead to a general strategy for assessing genetic and epigenetic contributions to tumorigenesis. | Li L Connelly MC Wetmore C Curran T Morgan JI | 2003 | 癌症2003，22，7： | 11 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | Elevation of circulating and ventricular adrenomedullin in human congestive heart failure 显示文摘 | JOUGASAKI M WEI C M Mc KINLEY L J | 1995 | Circulation1995，92，3： | 2 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | Processing and mechanical properties evaluation of a commingled carbon-fibre/PA12 composite composites part A显示文摘 | MC Donnell P MC Garvey K P Rochford L O Bradaigh C M | | Applied Science and Manufacturing0，，： | 1 |
| 6 | Automotive tribology o- verview of current advances and challenges for the future 显示文摘 | Simon C Tung M L Mc Millan | 2004 | Tribology International2004，1，37： | 1 |
| 7 | miR-337-3p and its targets STAT3 and RAPlA modulate taxane sensitivity in non-small cell lung cancers显示文摘 | Du L Subauste MC DeSevo C | 2012 | PLoS One2012，7，39： | 1 |
| 8 | High frequency of subtelomeric rearrangements in a cohort of 92 patients with severe mental retardation and dysmorphism显示文摘 | Novelli A Ceccarini C Bernardini L Zuccarello D Caputo V Diqilio MC | 2004 | Clin Genet2004，66，1： | 1 |
| 9 | Expression of adhe-sion factors induced by epileptiform activity in the endothelium of the isolated guinea pig brain in vitro显示文摘 | Librizzi L Regondi MC Pastoti C | 2007 | Epilepsia2007，48，4： | 1 |
| 10 | EULAR recommendations for the management of large vessel vasculitis显示文摘 | Mukhtyar C Guillevin L Cid MC | 2009 | Ann Rheum Dis2009，68，3： | 1 |
| 11 | Water-soluble polymers in enhanced oil recovery显示文摘 | Morgan S E Mc Cormick C L | 1990 | Progress in polymer science1990，15，1： | 1 |
| 12 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 13 | Advances in extracorporeal detoxification by MARS dialysis in patients with liver failure显示文摘 | Di Campli C Zileri Dal Verme L Andrisani MC | 2003 | Curr Med Chem2003，10，： | 1 |
| 14 | Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat显示文摘 | Trudel L Tomasetto C Rio MC | 2002 | Am J Physiol Gastrointest Liver Physion2002，282，6： | 1 |
| 15 | Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes显示文摘 | FRANKENFELD C L MC TIERNAN A M THOMAS W K | 2006 | Maturitas2006，53，3： | 1 |
| 16 | Genetic diversity of merozoite surface protein-1 gene of Plasmodium vivax solates in mining villages of Venezuela (Bolivar State)显示文摘 | Leclerc MC Gauthier C Villegas L | 2005 | Acta Trop2005，95，： | 1 |
| 17 | Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation显示文摘 | Mc Kinsey T A Zhang C L Lu J | 2000 | Nature2000，408，6808： | 1 |
| 18 | Advances in extracorporeal detoxifieation by MARS dialysis in patients with liver failure显示文摘 | Di Campil C Zileri Dal Verme L Andrisani MC | 2003 | Curr Med Chem2003，10，： | 1 |
| 19 | 'Diastolic heart fail ure'or heart failure caused by subtle left ventricular sys- tolic dysfunction显示文摘 | Petrie MC Caruana L Berry C | 2002 | Heart2002，87，1： | 1 |
| 20 | Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function显示文摘 | Anderson R C Cookson A L Mc Nabb W C | 2010 | FEMS Microbiology letters2010，309，2： | 1 |
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