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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 3 | 口干及其多种原因的诊治显示文摘老年口干是由多种原因引起的常见症状。口干并非衰老的正常现象,因而有必要阐明其原因。Sj(?)gren综合征可出现口干,经唇部活检即可确诊。使用各种药物也常伴发口干,症状严重时需调整剂量或停药。本文探讨了口干的治疗方法。 | Mc Donald E 萧爽 | 1992 | 国外医学(老年医学分册)1992，13，1： | 2 |
| 4 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 5 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 6 | Effect of wood species on property and weathering performance of wood plastic composites显示文摘 | James S Fabiyi Armando G Mc Donald | 2010 | Composites Part A2010，41，： | 1 |
| 7 | Mechanisms of adverse effects of anti-VEGF therapy for cancer 显示文摘 | Kamba T Mc Donald D M | 2007 | Br J Cancer2007，96，12： | 1 |
| 8 | Radial head subluxation:comparing two methods of reduction显示文摘 | Mc Donald J Whitelaw C Goldsmith LJ | 1999 | Acad Emerg Med1999，6，7： | 1 |
| 9 | The clinical and genetic features of COPD-asthma overlap syndrome显示文摘 | Harding M Cho M Mc Donald M L | 2014 | Eur Respir J2014，44，2： | 1 |
| 10 | Cell cycle control as a basis for cancer drug development 显示文摘 | Mc Donald E R Deiry W S | 2000 | Int J Oncol2000，，16： | 1 |
| 11 | Anticholinergic therapy for chronic asthma in children over two years of age显示文摘 | Mc Donald NJ Bara AI | 2003 | Cochrane Database Syst Rev2003，，00： | 1 |
| 12 | Attendance at specialist hepatitis clinics and initiation of antiviral treatment among persons chronically infected with hepatitis C:Examining the early impact of Scotland's Hepatitis C Action Plan显示文摘 | Mc Donald SA Hutchinson SJ Innes HA | 2014 | JViral Hepat2014，21，5： | 1 |
| 13 | Higher rate and earlier peritonitis in Aboriginal patients compared to non-Aboriginal patients with end-stage renal failure maintained on peritoneal dialysis in Australia:analysis of ANZDATA显示文摘 | Lim WH Johnson DW Mc Donald SP | 2005 | Nephrology(Carlton)2005，10，2： | 1 |
| 14 | Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes显示文摘 | Mc Donald SJ Middleton P Dowswell T | 2014 | Evid Based Child Health2014，9，2： | 1 |
| 15 | Delayed ettringite formation and curing implications of the work of Kelham显示文摘 | David Mc Donald | 1995 | Cement and Concrete Research1995，29，12： | 1 |
| 16 | Thromboxane synthesis by sources-other than platelets in association with complement induced pulmonary leukostasis and pulmonary hypertension in sheep显示文摘 | Mc Donald JW | 1983 | Circ Res1983，52，1： | 1 |
| 17 | To investigate the efficacy and intubation situation of rouronium in pediatric显示文摘 | MC Donald PF Ki jima S Kitao M | 1997 | Anesth Intens Care1997，25，： | 1 |
| 18 | Long-term urinary catheter users self-care practices and problems显示文摘 | Wilde MH Mc Donald MV Brasch J | 2013 | J Clin Nurs2013，22，34： | 1 |
| 19 | The anatomy and isometry of the midial patellofemoral ligament:implication for reconstruction显示文摘 | Steensen RN Dopirak RM Mc Donald WG 3rd | 2004 | AmJSports Med2004，32，： | 1 |
| 20 | Biophysical analysis of binding of WW domains of the YAP2 Transcriptional regulator to PPXY motifs within WBPl and WBP2 adaptors显示文摘 | Mc Donald CB Mc Intosh SK Mikles DC | 2011 | Biochemistry2011，，8： | 1 |
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