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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Expression of aspartyl beta-hydroxylase and its clinicopathological significance in hepatocellular carcinoma显示文摘 | Xian ZH Zhang SH Cong WM Yan HX Wang K Wu MC | 2006 | 第二军医大学学报2006，27，5： | 6 |
| 3 | 妊娠期高血压疾病对远期心血管病的影响显示文摘对妇女妊娠期高血压疾病(hypertensive disorder of pregnancy,HDP)史的研究,可能有助于改善动脉粥样硬化性心血管病的风险评估。但是,有HDP既往史的中年无症状妇女在未来患心血管病的风险仍未知。该研究旨在探讨有或无HDP既往史的中年女性心血管病的远期发病率。纳入标准:在前瞻性、观察性英国生物资料库中,纳入40~69岁并至少有一活产的英国妇女,对其中一亚组妇女进行了无创性动脉硬度测量。 | 周卫(译) 叶鹏(摘、审校) Honigberg MC Zekavat SM Aragam K Klarin D Bhatt DL Scott NS Peloso GM Natarajan P | 2020 | 中华高血压杂志2020，28，2： | 6 |
| 4 | Placental accommodations for transport and metabolism during intra-uterine crowding in pigs显示文摘Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight(and therefore reduced intrauterine space) in early gestation compared to late gestation. However, even in late gestation,mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from small fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose(glucosamine, glucuronic acid, iduronic acid)suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus.Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of m TOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis,but the details of these interactions remain unclear. In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the pig fetus, potentially increasing litter size and piglet birth weights. | Jeffrey L Vallet Anthony K Mc Neel Jeremy R Miles Bradley A Freking | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 5 |
| 5 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 6 | 颈动脉硬化进展与病程≥10年的高血压治疗之间的关系:多种族动脉粥样硬化研究显示文摘尚未有前瞻性多种族队列对抗高血压药物类别和动脉硬化进展的相关性进行研究。该研究所有受试者基线均患高血压,定义为血压≥140/90 mm Hg(1mm Hg=0.133kPa)或服用降压药物治疗。在5个时间点评估药物的服用情况和血压水平。通过超声在基线时和平均随访(9.4±0.5)年后测定右颈总动脉的杨氏弹性模量和扩张系数。 | Gepner AD Tedla Y Colangelo LA Tattersall MC Korcarz CE Kaufman JD Liu K Burke GL Shea S Greenland P Stein JH 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 7 | 冠状动脉钙化用于指导个性化阿司匹林治疗以预防心血管病:基于多民族动脉粥样硬化研究显示文摘最近美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)的一级预防指南建议,低剂量阿司匹林治疗仅适用于年龄40~70岁、患动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)风险较高,但出血风险不高的成年人。然而,尚不清楚如何更准确地识别出这些患者。根据2019年降低心血管病相对危险度和出血风险的阿司匹林荟萃分析研究数据,本研究旨在评估冠状动脉钙化(coronary artery calcium,CAC)在指导阿司匹林在一级预防中如何使用的价值。 | 周卫(译) 叶鹏(摘/审校) Achirica MC Miedema MD McEvoy JW Rifai MA Greenland P Dardari Z Budoff M Blumenthal RS Yeboah J Duprez DA Mortensen MB Dzaye O Hong J Nasir K Blaha MJ | 2020 | 中华高血压杂志2020，28，4： | 2 |
| 8 | Shaping the future of biomarker research in breast caneer to ensure clinical relevance显示文摘 | Hinestrosa MC Dickersin K Klein P | 2007 | Nat Rev Caneer2007，7，4： | 1 |
| 9 | Architecture of a validated microRNA: target interaction显示文摘 | Vella MC Reinert K Slack FJ | 2004 | Chem Biol2004，11，12： | 1 |
| 10 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 11 | Changes in mieroeystin production by Microcystis aeruginosa exposed to phytoplanktivorous and omnivorous fish 显示文摘 | JANGM H HA K LUCAS MC | 2004 | Aquatic Toxicology2004，68，1： | 1 |
| 12 | Twenty four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades显示文摘 | Umetani K Singer DH Mc Craty R | 1998 | J Am Coll Cardiol1998，31，3： | 1 |
| 13 | Processing and mechanical properties evaluation of a commingled carbon-fibre/PA12 composite composites part A显示文摘 | MC Donnell P MC Garvey K P Rochford L O Bradaigh C M | | Applied Science and Manufacturing0，，： | 1 |
| 14 | Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer 显示文摘 | Nakano K Watney E Mc Dougall JK | 1998 | Am J Pathol1998，153，3： | 1 |
| 15 | Effect of adsorbents coated with titanium dioxide on the photocatalytic degradation of propoxur 显示文摘 | Lu MC Chen J N Chang K T etal | 1999 | Chemosphere1999，38，： | 1 |
| 16 | Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system显示文摘 | Tsou K Brown S Sanudo-Pena MC | 1998 | Neuroscience1998，83，： | 1 |
| 17 | Effects of Differential Environments on Plasticity of Dendrites of Cortical Pyramidal Neurons in Adult Rats显示文摘 | UYLINGS HB KUYPERS K DIAMOND MC | 1978 | Exp Neurol(S0022-3069)1978，62，3： | 1 |
| 18 | Three cases of myocarditis in childhood associated with Human Parvovirus(B19 virus)显示文摘 | Munro K Croxson MC Thomas S | 2003 | Pediatr Cardiol2003，24，5： | 1 |
| 19 | Clinical outcomes of catheter substrate ablation for high-risk patients with atrial fibrillation显示文摘 | Nademanne K Schwab MC Kosar EM | 2008 | J Am Coil Cardiol2008，51，： | 1 |
| 20 | computed tomography image - guided surgery in complex acetabular fractures 显示文摘 | Broun GA Willis MC Firoozbakhsh K | 2000 | clim Orthop2000，370，1： | 1 |
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