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| 1 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 2 | A comparative study of sensor array and GC-MS:application to Madrid wines characterization显示文摘 | Santos JP Arroyo T Aleixandre M Lozano J Sayago I García M Femández MJ Arésa L Gutiérrez J Cabellos JM Gil M Horrillo MC | | 0，，02： | 1 |
| 3 | HIV-1 detection in cervicovaginal secretions during pregnancy显示文摘 | Ajaka I Mandelbrot L Delmas MC | 1997 | AIDS1997，11，13： | 1 |
| 4 | An improved in situ hybridization method for the detection of fish pathogens显示文摘 | Mc CARTHY U M URQUHART K L BRICKNELL I R | 2008 | J Fish Dis2008，31，9： | 1 |
| 5 | Theorphan nuclear receptor ROR gammat directs thedifferentiation program of proinfl ammatory IL-17+T helper cells显示文摘 | Ivanov I I Mc Kenzie B S Zhou L | 2006 | Cell2006，126，25： | 1 |
| 6 | Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings 显示文摘 | Vigone MC Fugazzola L Zamproni I | 2005 | Hum Mutat2005，26，4： | 1 |
| 7 | Long -term r i sk of incident v e r t e b r a 1 f r a c t u r e s 显示文摘 | Ca u 1 e y JA Ho c h b e r g MC L u i LY e t a 1 | | JAMA0，298，23： | 1 |
| 8 | Leukemic plasmacytoid dendritic cells share phenotypic and functional features with their normal counterparts显示文摘 | Chaperot L Perrot I Jacob MC | 2004 | Eur J Immunol2004，34，2： | 1 |
| 9 | The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-1igand 显示文摘 | Grouard G Rissoan MC Filgueira L Durand I Banchereau J Liu YJ | 1997 | J Exp Med1997，185，6： | 1 |
| 10 | Vertical root fracture in endodontically treated teeth: a review of 25 cases显示文摘 | Llena Puy MC Forner Navarro L Barbero Navarro I | 2001 | Oral Surg2001，92，5： | 1 |
| 11 | High in vivo expression of interleukin-17 receptor in synovial endothelial cel s and chondrocytes from arthritis patients显示文摘 | Honorati MC Meliconi R Pulsatel i L | | 0，，： | 1 |
| 12 | Hernialed lumbar intervertebral disc spontaneously produce matrix metalloproteinases,nitric oxide,in Mc Intyre-lcukin-6 and prostaglandin E显示文摘 | Kang J D Georgescu H I Mc Intyre-Larkin L | 1996 | Spine1996，21，2： | 1 |
| 13 | HIV-1 detection in cervicovaginal secretions during pregnancy 显示文摘 | Loussert-Ajaka I Mandelbrot L Dehnas MC | 1997 | AIDS1997，11，13： | 1 |
| 14 | Thyroid diseases after treatment of Hodgkin's disease显示文摘 | Hancock S L Cox R S Mc Dougall I R | 1991 | N Engl J Med1991，325，9： | 1 |
| 15 | In vitro study of the anti- Leishmanial activity of bi- odegradable nanoparticles显示文摘 | Venier Juliennne MC Vouldoukis I Monjour L | 1995 | Drug Target1995，3，1： | 1 |
| 16 | Poly- cystic ovaries and ovarian hyperstimulation syndrome: a systematic review显示文摘 | Tummon I Gavrilova-Jordan L Allemand MC | 2005 | Acta Obstet Gynecol Scand2005，84，7： | 1 |
| 17 | The striatal long non- coding RNA Abhdl los is neuroprotective against an N- terminal fragment of mutant huntingtin in vivo 显示文摘 | Franeelle I Galvan L Gaillard MC | 2015 | Neurobiol Aging2015，36，16： | 1 |
| 18 | Low absolute lymphocyte count is a poor prognostic factor in diffuse-large-B-cell-lymphoraa显示文摘 | Cox MC Nofroni I Ruco L | 2008 | Leuk Lym- phoma2008，49，9： | 1 |
| 19 | Thyroid dysfunction after radiotherapy in children with Hodgkin's disease显示文摘 | Constine L S Donalson S S Mc Dougall I R | 1984 | Cancer1984，53，4： | 1 |
| 20 | 查看详情显示文摘 | Sacchi MC Forlini F Tritto I Mendichi R Zannoni G Noristi L | | 0，，22： | 1 |
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