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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Corrosive injury to upper gastrointestinal tract: Still a major surgical dilemma显示文摘在里面发展并且发展中的国家,对是的胃肠的系统的腐蚀剂损害意外摄取或由于自我伤害的后果以前与十年相比成为了不太普通的现象。这能部分被归因于政府在 detergents 和另外的腐蚀剂产品和一般公共了解上在这些国家强加的更紧密的立法。最在这些国家忙碌上面的胃肠的外科的单位,特别在发达国家将仅仅每年遇到盒子的一个小数字。最好的管理途径上的最新的知识正在缺乏。在这篇文章,我们在场我们对在我们最后 2 年和新 Medline 文学搜索里的胸的单位的上面的胃肠道的腐蚀剂损害的二个形成对照的盒子的经验被执行了在上面的胃肠道的腐蚀剂损害的管理加亮争吵的区域。我们断定在管理如此的病人的主要原则要求腐蚀剂损害的病理生理学的好理解以便计划尖锐并且未来管理。当临床的图画广泛地变化,每个病人必须个别地被评估。症状独自是损害的一个不可靠的指南。 | Siew Min Keh Nzewi Onyekwelu Kieran McManus Jim McGuigan | 2006 | World Journal of Gastroenterology2006，12，32： | 8 |
| 3 | Linkage disequilibrium between polymorphisms in the human TNFRSF1B gene and their association with bone mass in perimenopausal women显示文摘 | Albagha O M E Tasker P N McGuigan F E A | 2002 | Hum Molec Genet2002，11，： | 2 |
| 4 | 文化研究与酷资本主义显示文摘本文追索文化研究领域的多种发展轨迹,明确了五种特定形态:理论主义、方法主义、实用主义、主观主义和消费主义。本文注重探讨英国消费主义的发展轨迹。尽管有人将这种发展轨迹冠名为'伯明翰学派'或'英国文化研究',但更准确的命名应为'霍尔派文化研究',因为该学派的领军人物和思想之源是斯图亚特.霍尔。当然,霍尔本人对其追随者们发展的消费主义思潮及相关问题并不负有必然的责任。在消费主义文化研究和消费者至上的新自由主义意识形态之间,很容易分辨出一种同族关系;而且在一定程度上,二者有汇合的趋势。后者将表示不满态度的符号融入资本主义文化之中,这里称为'酷资本主义'。本文追溯了'酷'的谱系,探讨了它在资本主义文化中的融合过程。消费主义和一维的文化研究在开始阶段旨在批判文化的、经济的和政治的各种主流形态,不过,这样的学术研究如今实际上已经徒有虚名。本文在结论中指出,文化研究应该为了公众利益重新强调其批判功能,并建立一种多维的分析框架。 | Jim McGuigan 彭发胜 | 2011 | 文化艺术研究2011，4，2： | 2 |
| 5 | Impact of medication adherence on hospitalization risk and healthcare cost显示文摘 | Sokul MC McGuigan KA Verbrugge RR | 2005 | Med Care2005，43，6： | 1 |
| 6 | Synthesis and anti-varicella-zoster virus activity of some novel bicyclic nucleoside inhibitors: effect of enhanced aqueous solubility 显示文摘 | BRANCALE A SRINIVASAN S McGUIGAN S | 2000 | Antiviral Chem Chemother2000，11，6： | 1 |
| 7 | Genetic variation in the PTH pathway and bone phenotypes in elderly women:evaluation of PTH,PTHLH,PTHR1 and PTHR2 genes显示文摘 | Tenne M McGuigan F | 2008 | Bone2008，42，4： | 1 |
| 8 | The influence of biomate- rials on endothelial cell thrombogenicity 显示文摘 | MCGUIGAN A P SEFTON M V | 2007 | Biomaterials2007，28，16： | 1 |
| 9 | Total thoracic oesophagectomy for oesophageal carcinoma:has it been worth it显示文摘 | McManus K Anikin V McGuigan J | | 0，，： | 1 |
| 10 | Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): Pd-catalysed synthesis of 5-aryl derivatives and their biological evaluation 显示文摘 | CARANGIO A McGUIGAN C ANDREI G | 2001 | Antiviral Chem Chemother2001，12，3： | 1 |
| 11 | Working life and physicalactivity in ankylosing spondylitis pre and post anti-tumor necrosisfactor-alpha therapy 显示文摘 | Prince DS McGuigan LE McGirr EE | 2014 | Int J Rheum Dis2014，17，2： | 1 |
| 12 | Right tracks wrong rails:the development of generic skills in highereducation显示文摘 | Leckey J&McGuigan M | 1997 | Research in Higher Education1997，38，3： | 1 |
| 13 | Reoperative surgery in sporadic Zollinger-Ellison Syndrome: long-term results 显示文摘 | Grobmyer SR Vogel SB McGuigan JE | 2009 | J Am Coil Surg2009，208，6： | 1 |
| 14 | LRP4 associa- tion to bone properties and fracture and interaction withgenes in the Wnt- and BMP signaling pathways显示文摘 | Kumar J Swanberg M Mcguigan F | 2011 | Bone2011，49，3： | 1 |
| 15 | Cyclical etidronate plus ergocalciferol prevents glucocorticoid-induced bone loss in postmenopausal woman显示文摘 | Diamond T McGuigan L Barbagallo S | 1995 | Am J Med1995，98，： | 1 |
| 16 | Synthesis and evaluation of novel amidate prodrug of PMEA and PMPA 显示文摘 | Ballatore C McGuigan C De Clercq E | 2001 | BioorgMed Chem Lett2001，11，8： | 1 |
| 17 | Estrogen receptor α gene polymorphisms and bone mineral density: haplotype analysis in women from the United Kingdom显示文摘 | Albagha OM McGuigan FE Reid DM | 2002 | J Bone Miner Res2002，16，： | 1 |
| 18 | Vascularized organoid engineered by modular assembly enables blood perfusion 显示文摘 | McGuigan AP Sefton MV | 2006 | Proceed- ings of the National Academy of Sciences ( PNAS)2006，103，11： | 1 |
| 19 | Skin substitutes as alternatives to autografting in a wartime trauma setting显示文摘 | McGuigan FX | | 0，，10： | 1 |
| 20 | Effects of resistance training on running economy and cross-country performance显示文摘 | Barnes KR Hopkins WG McGuigan MR | 2013 | Med Sci Sports Exerc2013，45，12： | 1 |
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