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| 1 | Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation显示文摘Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal varices.However,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this risk.Our objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to EVL.Results:Totally 111 patients were divided into three groups according to platelet count:(1)<50×109/L(n=38,34.2%);(2)50×109/L to 100×109/L(n=47,42.3%);and(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ADAMTS-13.Post-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function parameters.Conclusion:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding. | Evandro de Oliveira Souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 3 |
| 2 | Epidemiology of upper gastrointestinal symptoms in Brazil(Epi Gastro):A population-based study according to sex and age group显示文摘AIM:To determine the prevalences of symptoms consistent with gastroesophageal reflux disease(GERD)and dyspepsia in South America.METHODS:A telephone survey was conducted among adult owners of land-based telephones in S?o Paulo,Brazil,using previously validated computer-assisted sampling and survey protocols.The Portugueselanguage survey included(1)sociodemographic characteristics(e.g.,weight,height,smoking)and comorbidities;(2)dietary habits;(3)presence of symptoms consistent with GERD or dyspepsia within the prior 3mo;and(4)use of medications and other therapies to manage symptoms.Data were stratified post-hoc into three homogeneous geographical regions of S?o Paulo according to the Social Exclusion Indices of the districts and postal codes.Survey response data from each respondent were weighted by the numbers of adults and landline telephones in each household.The analyses were weighted to account for sampling design and to be representative of the S?o Paulo population according to city census data.RESULTS:Among 4570 households contacted,an adult from 3050(66.7%)agreed to participate.The nonresponse rate was 33.3%.The mean(SE)respondent age was 42.6(16.0)years.More than half of all respondents were women(53.1%),aged 18 through 49 years(66.7%),married or cohabitating(52.5%),and/or above normal-weight standards(i.e.,35.3%overweight and 16.3%obese).A total of 26.5%of women were perimenopausal.More than 20%of respondents reported highly frequent symptoms consistent with GERD(e.g.,gastric burning sensation=20.8%)or dyspepsia(e.g.,abdominal swelling/distension=20.9%)at least once per month.Prevalences of these symptoms were significantly(approximately 1.5-to 2.0-fold)higher among women than men but did not vary significantly as a function of advancing age.For instance,14.1%of women reported that they experienced stomach burning(symptom of GERD)at least twice per week,compared to 8.4%of men(P=0.012 byχ2 test).A total of 15.7%of women reported that they experienced abdominal swelling(symptom of dyspepsia)at least twice per week,compared to 6.4%of men(P<0.001byχ2 test).Despite frequent manifestations of GERD or dyspepsia,most(≥90%)respondents reported that they neither received prescription medications fromphysicians,nor took behavioral measures(e.g.,dietary modifications),to manage symptoms.CONCLUSION:Symptoms consistent with dyspepsia and GERD are prevalent in Brazil and represent major public-health and clinical challenges. | Maria do Rosário Dias de Oliveira Latorre Aline Medeiros da Silva Décio Chinzon Jaime N Eisig Telma RP Dias-Bastos | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 3 | Application of a modified Judd-Ofelt theory to praseodymium-doped fluoride glasses 显示文摘 | Medeiros Neto J A Hewak D W Tate H | 1995 | J Non-crys Sol1995，183，： | 2 |
| 4 | Acrylamide formation in fried potato products – Present and future, a critical review on mitigation strategies显示文摘 | Raquel Medeiros Vinci Frédéric Mestdagh Bruno De Meulenaer | 2011 | Food Chemistry2011，，4： | 2 |
| 5 | lmmunophenotypic characterization of peripheral T lymphocytes in Mycobacterium tuberculo- sis infection and disease显示文摘 | Rodrigues D S Medeiros E A Weckx L Y | 2002 | Clin Exp Immunol2002，128，1： | 1 |
| 6 | Periodic Solutions for Nonlinear Systems with Mean Curvature-Like Operators显示文摘 | Benevieri P DoO J M Medeiros E S D | 2006 | Nonlinear Analysis:Real Word Applications2006，65，7： | 1 |
| 7 | Advances in the recognition of tubal intraepithelial carcinoma:applications to cancer screening and the pathogenesis of ovarian cancer显示文摘 | Lee Y Medeiros F Kindelberger D | 2006 | Adv Anat Pathol2006，13，1： | 1 |
| 8 | Periodic Solutions for Nonlinear Equations with Mean Curvature-like Operators显示文摘 | Benevieri P DoO J M Medeiros E S D | 2007 | Applied Mathematics Letters2007，20，5： | 1 |
| 9 | Hydrogen peroxide pre - treatment induces salt - stress acclimation in maize plants 显示文摘 | Neto A D de A Prisco J T Eneas - Filho J Medeiros J V R Gomes -Filho E | 2005 | Journal of Plant Physiology2005，162，10： | 1 |
| 10 | Kuaba approach: integrating formal semantics and design rationale representation to support design reuse 显示文摘 | de Medeiros A P Schwabe D | 2008 | Artificial Intelligence for Engineering Design Analysis and Manufacturing2008，22，4： | 1 |
| 11 | Tempol pre- vents impairment of the endothelial cell wound healing response caused by ionising radiation 显示文摘 | Braunhut S J Medeiros D Lai L | 1996 | Br J Cancer Suppl1996，27，： | 1 |
| 12 | Detecting glaucoma using automated pu- pillography 显示文摘 | TATHAM AJ MEIRA-FREITAS D WEINREB RN ZANGWILL LM MEDEIROS FA | 2014 | Ophthalmology2014，121，6： | 1 |
| 13 | Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome显示文摘 | Amato M B Barbas C S Medeiros D M | 1998 | N Engl J Med1998，338，： | 1 |
| 14 | High - temperature conditioning induces chilling tolerance in mandarin fruit: a cell wall approach 显示文摘 | Holland N Nunes F L de Medeiros I U D | 2012 | Journal of the Science of Food and Agriculture2012，92，15： | 1 |
| 15 | Overexpression of follistatin in trout stimulates increased muscling显示文摘 | Medeiros E F Phelps M P Fuentes F D | 2009 | American Journal of Physiology-regulatory Integrative and ComparativePhysiology2009，297，： | 1 |
| 16 | The role of tau in Alzheimer's disease and related disorders 显示文摘 | Medeiros R Baglietto Vargas D LaFerla F M | 2011 | CNS neuroscience & therapeutics2011，17，5： | 1 |
| 17 | Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study显示文摘 | Medeiros FA Meira-Freitas D Lisboa R | 2013 | Ophthalmology2013，120，8： | 1 |
| 18 | Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome显示文摘 | Amato M B P Barbas C S V Medeiros D M | 1998 | N Engl J Med1998，338，： | 1 |
| 19 | Tempol prevents impairment of the endothelial cell wound healing response caused by ionising radiation显示文摘 | Braunhut S J Medeiros D Lai L | 1996 | Br J Cancer Suppl1996，27，： | 1 |
| 20 | Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome显示文摘 | Amato M B Barbas C S Medeiros D M | 1998 | N Engl J Med1998，338，： | 1 |
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