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22篇 您的检索式：作者名="MELAYAH"

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	题名	作者	年代	出处	被引量
1	CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL.	Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed	2018	Cellular & Molecular Immunology2018，15，2：	2
2	Agrobacterium tumefaciens-mediated transformation as a tool for inser- tional mutagenesis in the symbiotic ectomycorrhizal fun- gus Hebeloma cylindrosporum 显示文摘	Combier J P Melayah D Raffler C	2003	FEMS Microbiol Lett2003，220，：	1
3	Agrobacterium tumefaciens -mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum 显示文摘	Combier J P Melayah D Rafter C	2003	FEMS Microbiology Letters2003，220，：	1
4	Agrobacterium tumefaciens-mediated transformation as a tool for insertionalmutagenesis in the symbiotic ectomycor-rhizal fungusHebeloma cylindrosporum显示文摘	Combier J P Melayah D Raffier C		0，，01：	1
5	Agrobacterium tumefaciens-mediated transformation as a tool for insertionalmutagenesis in the symbiotic ectomycor-rhizal fungusHebeloma cylindrosporum显示文摘	Combier J P Melayah D RaffierC	2003	Fems Microbiology Letters2003，220，1：	1
6	Agrobacterium tumefacie- ns-mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum 显示文摘	Combier JP Melayah D Raffier C	2003	FEMS Microbiology Letters2003，220，1：	1
7	Agrobacterium tumefaciens-mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum显示文摘	Combier JP Melayah D Raffier C	2003	FEMS Microbiol Lett2003，220，：	1
8	The mobility of the tobacco Tnt1 retrotransposon correlates with its transcriptional activation by fungal factors显示文摘	Bonnivard E Chalhoub B	2001	Plant J2001，28，2：	1
9	Agrobacterium tumefaciens-mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum显示文摘	Combier J P Melayah D Raffler C	2003	FEMS Microbiology Letters2003，220，1：	1
10	Agrobacterium tume faciens-mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum 显示文摘	COMBIER JP MELAYAH D RAFFIER C	2003	FEMS Microbiol Lett2003，220，：	1
11	Agrobacteriumtumefaciens-mediated transformation as a tool for insertionalmutagenesis in the symbiotic ectomycorrhizal fungusHebeloma cylindrosporum显示文摘	Combier J P Melayah D Raffier C	2003	FEMS MicrobiologyLetters2003，220，1：	1
12	Agrobacte- rium turnefaciens-mediated transformation as a tool for insertional mutagenesis in the symbiotic eetomy- eorrhizal fungus Hebeloma cylindrosporum 显示文摘	Combier J P Melayah D Raffler C	2003	FEMS Microbiology Letters2003，220，1：	1
13	Agrobacterium tumefaciens-mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum显示文摘	Combier JP Melayah D Raffier C	2003	FEMS Microbiol Lett2003，220，：	1
14	Agrobacterium tumefaciens-mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum 显示文摘	COMBIER J P MELAYAH D RAFFIER C	2003	FEMS Microbiol Lett2003，220，1：	1
15	The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis 显示文摘	Martin F Aerts A Ahrén D Brun A Danchin EGJ Duchaussoy F Gibon J Kohler A Lindquist E Pereda V Salamov A Shapiro HJ Wuyts J Blaudez D Buée M Brokstein P Canb?ck B Cohen D Courty PE Coutinho PM Delaruelle C Detter JC Deveau A Difazio S Duplessis S Fraissinet-Tachet L Lucic E Frey-Klett P Fourrey C Feussner I Gay G Grimwood J Hoegger PJ Jain P Kilaru S Labbé J Lin YC Legué V Le Tacon F Marmeisse R Melayah D Montanini B Muratet M Nehls U Niculita-Hirzel H Secq MPOudot-Le Peter M Quesneville H Rajashekar B Reich M Rouhier N Schmutz J Yin T Chalot M Henrissat B Kües U Lucas S van de Peer Y Podila GK Polle A Pukkila PJ Richardson PM Rouzé P Sanders IR Stajich JE Tunlid A Tuskan G Grigoriev IV	2008	Nature2008，452，：	1
16	Agrobacterium tumefaciens-mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum显示文摘	Combier J P Melayah D Raffier C	2003	FEMS Microbiology Letters2003，220，1：	1
17	The mobility of the tobacco Tntl retrotransposon correlates with its transcriptional activation by fungal factors显示文摘	Melayah D Bonnivard E Chalhoub B		0，，02：	1
18	Agrobacterium tumefaciens mediated tran- sformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma eylindrosporum 显示文摘	COMBIER JP MELAYAH D RAFFIER C	2003	FEMS Microbiol Lett2003，220，1：	1
19	Agrobacterium tumefaciens-mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum显示文摘	Jean-Philippe Combier Delphine Melayah Colette Raffier	2003	FEMS Microbiology Letters2003，，：	1
20	Agrobacteriu m tumefaciens-mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma Cylindrosporum显示文摘	Combier J P Melayah D Raffier C	2003	FEMS Microbiology Letters2003，220，1：	1

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