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| 1 | Prevalence of vacA, cagA and babA2 genes in Cuban Helicobacter pylori isolates显示文摘AIM: To investigate the prevalence of vacuolating cytotoxin (vacA), cytotoxin associated gene A (cagA) and blood adhesion binding antigen (babA2) genotypes of Helicobacter pylori (H pylori) isolates from Cuban dyspeptic patients. METHODS: DNA was extracted from H pylori-positive cultures taken from 130 dyspeptic patients. Genotyping was performed by PCR, using specifi c primers for vacA (s1, s2, m1, m2), cagA and babA2 genes. Endoscopic observations and histological examinations were used to determine patient pathologies. RESULTS: vacA alleles s1 , s2 , m1 and m2 were detected in 96 (73.8%), 34 (26.2%), 75 (57.7%) and 52 isolates (40%), respectively, while the cagA gene was detected in 95 isolates (73.2%). One hundred and seven isolates (82.3%) were babA2-positive. A signif icant correlation was observed between vacAs1m1 and cagA and between vacAs1m1 and babA2 genotypes (P < 0.001 and P < 0.05, respectively) and between babA2 genotype and cagA status (P < 0.05); but, no correlation was observed between vacAs1 and babA2 genotypes. Eighty fi ve (65.4%) and 73 (56.2%) strains were type 1 (vacAs1-cagA-positive) and 'triple- positive' (vacAs1-cagA-babA2-positive), respectively, and their presence was significantly associated with duodenal ulcer (P < 0.01 and P < 0.001, respectively). CONCLUSION: The distribution of the main virulence factors in the Cuban strains in this study resembled that of the Western-type strains, and the more virulent H pylori isolates were signifi cantly associated with duodenal ulcer, ulcer disease being the worst pathology observed in the group studied. | Lino E Torres Karelia Melián Arlenis Moreno Jordis Alonso Carlos A Sabatier Mayrín Hernández Ludisleydis Bermúdez Boris L Rodríguez | 2009 | World Journal of Gastroenterology2009，15，2： | 4 |
| 2 | Systemic levels of II-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis显示文摘 | Melis L Vandooren B Krui-Thof E | 2010 | Ann Rheum Dis2010，69，： | 1 |
| 3 | Evaluation of the interactionmechanisms between red muds and heavy metals 显示文摘 | Santona L Castaldi P Melis P | 2006 | Journal ofHazardous Materials2006，136，2： | 1 |
| 4 | Sustained photobiological hydrogen gas production upon reversible inactivation of oxygen evolution in the green algae chlamydomonas reinhardtii 显示文摘 | Melis A Zhang L Forestier M | 2000 | Plant Physiology2000，22，： | 1 |
| 5 | Cholel Jthiasis and renal cystssimul-taneous laparoscopic treatment 显示文摘 | Zarba ME Meli L Forti A | 2010 | Ohir Ital2010，55，4： | 1 |
| 6 | Prediction and analysis of subsidence induced by shield tunneling in the madrid metro extension显示文摘 | MELIS M MEDINA L RODRIGUEZ J M | 2002 | Canadian Geotechnical Journal2002，，39： | 1 |
| 7 | Heavy metal immobilization by chemical amendments in a polluted soil and influence on white lupin growth 显示文摘 | Castaldi P Santona L Melis P | 2005 | Chemosphere2005，60，3： | 1 |
| 8 | Evaluation of the interaction mechanisms between red muds and heavy metals 显示文摘 | Santona L Castaldi P Melis P | 2006 | Journal of Hazardous Materials2006，136，2： | 1 |
| 9 | Autism and phenylketonuria显示文摘 | Baieli S Pavone L Meli C | 2003 | J Autism Dev Disord2003，33，2： | 1 |
| 10 | Biochemical and morphological characterization of sulfur-deprived and H2-producing Chlamydomonas reinhardtii (green alga)显示文摘 | ZHANG L HAPPE T MELIS A | 2002 | Planta2002，214，4： | 1 |
| 11 | Development and application of a universal hemoplasma screening assay based on the SYBR Green PCR principle显示文摘 | WILLI B MELI M L LOTHY R | 2009 | Journal of Clinical Microbiology2009，47，12： | 1 |
| 12 | The influence of cobalt on the electrochemical cycling stability of LaNi5-based hydride forming alloys 显示文摘 | CHARTOUNI D MELI F ZUTTEL A GROSS K SCHLAPBACH L | 1996 | J Alloys Comp1996，241，： | 1 |
| 13 | Evaluation of the interaction mechanisms between red muds and heavy metals显示文摘 | Santona L Castaldi P Melis P | 2006 | Journal of Hazardous Materials2006，136，2： | 1 |
| 14 | Heavy metal immobilization bychemical amendments in a polluted soil and influence on whitelupin growth显示文摘 | Castaldi P Santona L Melis P | 2005 | Chemosphere2005，66，： | 1 |
| 15 | Path-Dependent morphology and relaxation kinetics of highly amphiphilic diblock copolymer micelles in ionic liquids显示文摘 | Meli L Santiago J M Lodge T P | | 0，，04： | 1 |
| 16 | Electrochemical and surface properties of low cost, cobalt-free LaNi5-type hydrogen storage alloys 显示文摘 | MELI F ZUTTEL A SCHLABACH L | 1993 | J Alloys Comp1993，202，： | 1 |
| 17 | Venom immunotherapy induces monocyte activation显示文摘 | Magnan A marin V Mely L | 2001 | Clinical and Experimental Allergy2001，31，8： | 1 |
| 18 | Surface and bulk properties of LaNis-xSix alloys from the viewpoint of battery applications 显示文摘 | MELI F ZUETTEL A SCHLAPBACH L | 1992 | Journal of Alloys and Compounds1992，190，： | 1 |
| 19 | 显示文摘 | Züttel A Meli F Schlapbach L | 1994 | J Alloys Comp1994，209，： | 1 |
| 20 | Radiation characteristics of Chlamy- domonas reinhardtii CC125 and its tnmcated chlorophyll antenna transformants tlal, tlaX, and tlal-CW + 显示文摘 | Berberoglu H Pilon L Melis A | 2008 | Intl J Hydrogen Energy2008，33，： | 1 |
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