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| 1 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation显示文摘 | Jose A. Rodríguez-Navarro Laura Rodríguez María J. Casarejos Rosa M. Solano Ana Gómez Juan Perucho Ana María Cuervo Justo García de Yébenes María A. Mena | 2010 | Neurobiology of Disease2010，，3： | 2 |
| 3 | SSJD15011600007878显示文摘 | María A. Mejía-Benítez Amélie Bonnefond Lo?c Yengo Marlène Huyvaert Aurélie Dechaume Jesús Peralta-Romero Miguel Klünder-Klünder Jaime García Mena Julia S. El-Sayed Moustafa Mario Falchi Miguel Cruz Philippe Froguel | 2015 | Diabetologia2015，，2： | 2 |
| 4 | A selective fluorescent probe for the detection of mercury(11) in aqueous media and its applications in living cells显示文摘 | Garcia-Beltran O Mena N Berrios T A | 2012 | Tetrahedron Letters2012，53，48： | 1 |
| 5 | Effect of solids on homogeneous-heterogeneous flow regime transition in bubble cohimns 显示文摘 | Mena P C Ruzicka M C Rocha F A | 2005 | Chemical Engineering Science2005，60，22： | 1 |
| 6 | Using image analy- sis in the study of multiphase gas absorption 显示文摘 | Mena P C Pons M N Teixeira J A | 2005 | Chemi- cal Engineering Science2005，60，18： | 1 |
| 7 | Glia protect fetal mid- brain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms 显示文摘 | Mena MA Casarejos MJ Carazo A | 1997 | J Neural Transm1997，104，： | 1 |
| 8 | Development of a tyrosinase biosensor based on gold nanoparticles-modified glassy car- bon electrodes: Application to the measurement of a bioelectrochemical polyphenols index in wines显示文摘 | SANZ V C MENA M L GONZ LEZ-CORT S A | 2005 | Anal Claim Aeta2005，528，1： | 1 |
| 9 | An automatic method for road extraction in rural and semi -urban areas starting from high resolution sat- ellite imagery 显示文摘 | J B Mena J A Malpiea | 2005 | Pattern Recognition Letters2005，26，3： | 1 |
| 10 | Impact of physicochemi- cal parameters on in vitro assembly and disassembly kinetics of recombinant triple-layered rotavirus-like particles 显示文摘 | Mellado MC Mena JA Lopes A | 2009 | Biotechnol Bioeng2009，104，4： | 1 |
| 11 | Development of a tyrosinase biosensor based on gold nanoparticles-modified glassy carbon electrodes application to the measurement of a bioelectroehemical polyphenols index in wines显示文摘 | SANZ V C MENA M L CORTES A G | 2005 | Anal China Acts2005，528，： | 1 |
| 12 | Hepcidin inhibits apical iron uptake in intestinal cells显示文摘 | Mena NP Esparza A Tapia V | 2008 | Am J Physiol Gastrointest Liver Physiol2008，294，： | 1 |
| 13 | New or interesting hyphomycetes from the Biosphere Reserve of Sierra del Rosario, Cuba显示文摘 | Mena P J Delgado-Rodriguez G~ Mercado-Sierra A | 2001 | Mycologia2001，93，： | 1 |
| 14 | Differential expression of pathogen-responsive genes encoding two types of glycine-rich proteins in barley 显示文摘 | Molina A Mena M Carbonero P | 1997 | Plant Mol Biol1997，33，： | 1 |
| 15 | An automatic method forroad extraction in rural and semi-urban areas startingfrom high resolution satellite imagery显示文摘 | MENA J B MALPICA J A | 2005 | Pattern Recog-nition Letter2005，26，9： | 1 |
| 16 | Moderate hypothermia in the management of severe traumatic brain injury:a good idea proved ineffective显示文摘 | Sahuquillo J Mena MP Vilalta A | 2004 | Curr Pharm Des2004，10，18： | 1 |
| 17 | Comprehensive analysis of gluten in processed foods using a new extraction method and a competitive ELISA based on the R5 antibody显示文摘 | Mena M C Lombardia M Hemando A | | 0，，15： | 1 |
| 18 | Down-regulation of adhesionmolecules and other inflammatory biomarkers after moderate wine consumptionin healthy women:a randomized trial显示文摘 | Sacanella E V(a)zquez-Agell M Mena MP | 2007 | Am J Clin Nutr2007，86，5： | 1 |
| 19 | Effects of calcium antagonists on the dopamine system 显示文摘 | Mena M A Garcla de Y6benes M J Tabernero C | 1995 | Clin Neuropharmacol1995，18，5： | 1 |
| 20 | Symptoms at the menopausal and premenopausal years : their relationship with, glucose, cortisol, FSH, prolactin, obedity and attitudes towards sexuality显示文摘 | Huer Ta R Mena A | 1995 | Psychoneuroen-docrinology1995，20，8： | 1 |
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