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| 1 | Mechanokinetics of receptor-ligand interactions in cell adhesion显示文摘Receptor-ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade,platelet thrombosis,as well as tumor metastasis.To mediate cell adhesion,the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum,i.e.,two-dimensional(2D)binding,which is different from the binding of a soluble ligand in fluid phase to a receptor,i.e.,three-dimensional(3D) binding.While numerous works have been focused on3 D kinetics of receptor-ligand interactions in the immune system,2D kinetics and its regulations have been less understood,since no theoretical framework or experimental assays were established until 1993.Not only does the molecular structure dominate 2D binding kinetics,but the shear force in blood flow also regulates cell adhesion mediated by interacting receptors and ligands.Here,we provide an overview of current progress in 2D binding and regulations,mainly from our group.Relevant issues of theoretical frameworks,experimental measurements,kinetic rates and binding affinities,and force regulations are discussed. | Ning Li Shouqin Lü Yan Zhang Mian Long | 2015 | Acta Mechanica Sinica2015，31，2： | 5 |
| 2 | Flow dynamics analyses of pathophysiological liver lobules using porous media theory显示文摘Blood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the liver lobule,is difficult to determine experimentally in humans due to its complicated structure, with radially branched microvasculature and the technical difficulties that derive from its geometric constraints. Here we established a set of 3D computational models for a liver lobule using porous media theory and analyzed its flow dynamics in normal, fibrotic,and cirrhotic lobules. Our simulations indicated that those approximations of ordinary flow in portal tracts(PTs) and the central vein, and of porous media flow in the sinusoidal network, were reasonable only for normal or fibrotic lobules.Models modified with high resistance in PTs and collateral vessels inside sinusoids were able to describe the flow features in cirrhotic lobules. Pressures, average velocities, and volume flow rates were profiled and the predictions compared well with experimental data. This study furthered our understanding of the flow dynamics features of liver lobules and the differences among normal, fibrotic, and cirrhotic lobules. | Jinrong Hu Shouqin Lü Shiliang Feng Mian Long | 2017 | Acta Mechanica Sinica2017，33，4： | 4 |
| 3 | Probe stiffness regulates receptor-ligand bond lifetime under force显示文摘Receptor-ligand bond dissociation under applied force is crucial to elucidate its biological functionality when the molecular bond is usually connected to a mechanical probe. While the impact of probe stiffness, k, on bond rupture force has recently attracted more and more attention, the mechanism of how it affects the bond lifetime, however, remains unclear. Here we quantified the dissociation lifetime of selectin-ligand bond using an optical trap assay with low stiffness ranging from 3.5×10-3 to 4.7×10-2 pN/nm. Our results indicated that bond lifetime yielded distinct distributions with different probe stiffness, implying the stochastic feature of bond dissociation. It was also found that the mean lifetime varied with probe stiffness and that the catch bond nature was visualized at k■3.0×10-2 pN/nm. This work furthered the understanding of the forced dissociation of selectin-ligand bond at varied probe stiffness, which is physiologically relevant to the tethered rolling of leukocytes under blood flow. | ZHANG Yan LüShouQin &LONG Mian | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，5： | 3 |
| 4 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 5 | Global mapping of live cell mechanical features using PeakForce QNM AFM显示文摘Atomic force microscopy(AFM)has been widely used to acquire surface topography upon different scanning modes and to quantify mechanical properties of a cell using single-point ramp force mode.However,these traditional measurements need massive force curves originating from multiple points of a cell to exclude the potential errors resulted from limited and factitious selections of testing points,making the measurements time-consurming and highly localized.PeakForce Quantitative NanoMe-chanics(PF QNM)is a high-speed(faster by 3-4 order of magnitude)and global surface mechanical property mapping method with high spatial resolution,overcoming the drawbacks of traditional ramp mode especially used for a live cell with high heterogeneity.In this protocol,we elaborated how to run PF QNM measurements for live cells and relevant modification may be needed when extending this method to other cell-like soft materials. | Jinrong Hu Shenbao Chen Dandan Huang Yan Zhang Shouqin Lü Mian Long | 2020 | Biophysics Reports2020，6，1： | 2 |
| 6 | Cutting edge:FimH adhesin of type 1 fimbriae is a novel TLR4 ligand显示文摘 | Mossman K L Mian M F Lauzon N M | 2008 | J Immunol2008，81，10： | 1 |
| 7 | Porous calcium phosphate ceramics modified with PLGA-bioactive glass显示文摘 | Mian X Tan L P Tan L S | 2007 | Materials Science and Engineering2007，27，2： | 1 |
| 8 | A Novel Approach to Determine the Glyphosate Tolerant Trait in Soybeans显示文摘 | MIAN C L PANTALONE V R MUELLER T C | 2004 | J Agric Food Chem2004，52，： | 1 |
| 9 | Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma 显示文摘 | Ang S Mills L Mian B | 2002 | Am J Pathol2002，161，1： | 1 |
| 10 | Chondrocyte transplantation显示文摘 | Mians T Peterson L | 1997 | Operative Tech Orthop1997，7，： | 1 |
| 11 | uCyt+/ImmunoCyt in the detection of recurrent urothelial carcinoma:an update on,1991 analyses显示文摘 | Mian C Maier K Comploj E Lodde M Bemer L Lusuardi L | | 0，，： | 1 |
| 12 | Efficient photoeatalytic degradation of environmental pollutants with mass-produced ZnS nanoerystals 显示文摘 | Torres-Martinez C L Kho R Mian O I Mehra R K | 2001 | J Colloid Interface Sci2001，240，2： | 1 |
| 13 | Laser bonded micro- joints between titanium and polyimide for applications in medical implants 显示文摘 | Mian A Newaz G Vendra L | 2005 | Materials Science: Materials in Medicine2005，16，3： | 1 |
| 14 | Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow显示文摘Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the underlying receptor–ligand bindings. While theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately, how to couple these two processes remains unclear. Here we develop a combined model that couples cellular aggregation dynamics and adhesion kinetics under shear flow. The impacts of shear rate(or shear stress)and molecular binding affinity were elucidated. This study provides a unified model where the action of a fluid flow drives cell aggregation and adhesion under the modulations of the mechanical shear flow and receptor–ligand interaction kinetics. It offers an insight into understanding the relevant biological processes and functions. | Yu Du Shuang Peng Yuhong Cui Shouqin Lü Yan Zhang Mian Long | 2015 | Theoretical & Applied Mechanics Letters2015，5，6： | 1 |
| 15 | Fully humanized neutralizing antibodies to interleukin-8(ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma显示文摘 | Huang S Mills L Mian B | 2002 | Am J Pathol2002，161，1： | 1 |
| 16 | Do lenders favor politically con- nected firms? Rent provision in an emerging financial market 显示文摘 | Khwaja A L Mian A | 2005 | Quarterly Journal of Economics2005，120，： | 1 |
| 17 | Cutting Edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand显示文摘 | KAREN L MOSSMAN M FIROZ MIAN NICOLE M | 2008 | Immunol2008，181，： | 1 |
| 18 | Efficient photocatalytic degradation of environmental pollutants with mass-produced ZnS nanocrystals显示文摘 | Torres-Martinez C L Kho R Mian O I | 2001 | J Colloid Interface Sci2001，240，2： | 1 |
| 19 | Role of uCyt in the detection and surveillance of urothelial carcinoma显示文摘 | Lodde M Mian C Negfi G Bemer L Maffei N Lusuardi L | | 0，，： | 1 |
| 20 | Accounts Receivable Management Policy-theory and Evidence显示文摘 | Mian S L C W Smith | 1992 | Journal of Finance1992，47，1： | 1 |
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