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| 1 | Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine显示文摘AIM: To investigate the reduction in hepatitis B virus(HBV) covalently closed-circular DNA(ccc DNA) with entecavir(ETV) or lamivudine(LAM). METHODS: This analysis included patients who had participated in the randomized Phase Ⅲ study ETV-022 comparing ETV vs LAM in nucleos(t)ide-naive, HBe Agpositive patients. Patients received ETV(0.5 mg daily) or LAM(100 mg daily) for a minimum of 52 wk. Patients were eligible to participate in this sub-study if they had paired biopsies at baseline and week 48 with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA. The main objective was to compare changes in hepatic HBV ccc DNA and total hepatic HBV DNA at week 48 of ETV or LAM treatment, which was a secondary endpoint of study ETV-022. Additional post hoc analyses included linear regression analyses to assess associations of baseline levels and on-treatment changes of ccc DNA with other baseline factors [sex,age, serum HBV DNA, alanine aminotransferase(ALT), Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBV genotype], or ontreatment factors(changes from baseline at week 48 in serum HBV DNA, ALT, Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBe Ag loss at week 48).RESULTS: Overall, 305 patients(ETV = 159; LAM = 146) of ETV-022 had paired baseline and week 48 liver biopsies with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA, and were included in this analysis. Baseline demographics and disease characteristics were comparable between the two arms. After 48 wk, ETV resulted in significantly greater reductions in hepatic HBV ccc DNA [-0.9 log10 copies/human genome equivalent(HGEq) vs-0.7 log10 copies/HGEq; P = 0.0033] and total hepatic DNA levels(-2.1 log10 copies/HGEq vs-1.6 log10 copies/HGEq; P < 0.0001) than LAM. Virologic, biochemical, and histologic response rates at week 48 were also greater with ETV than with LAM. Baseline HBV ccc DNA levels were positively associated with baseline levels of serum HBV DNA and total hepatic HBV DNA, and negatively associated with HBV genotype F. On-treatment changes in HBV ccc DNA levels were negatively associated with baseline levels of serum HBV DNA and baseline ALT, and were positively associated with on-treatment changes in the levels of serum HBV DNA, total hepatic HBV DNA levels, and ALT, change in Knodell necroinflammatory score, and HBe Ag loss.CONCLUSION: Forty-eight weeks of ETV resulted in greater reductions in ccc DNA and total hepatic HBV DNA than LAM, but long-term therapy may be needed for ccc DNA elimination. | Scott Bowden Stephen Locarnini Ting-Tsung Chang You-Chen Chao Kwang-Hyub Han Robert G Gish Robert A de Man Miao Yu Cyril Llamoso Hong Tang | 2015 | World Journal of Gastroenterology2015，21，15： | 11 |
| 2 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 3 | Blue light is more essential than red light for maintaining the activities of photosystem Ⅱ and Ⅰ and photosynthetic electron transport capacity in cucumber leaves显示文摘Blue and red lights differently regulate leaf photosynthesis. Previous studies indicated that plants under blue light generally exhibit better photosynthetic characteristics than those under red light. However, the regulation mechanism of related photosynthesis characteristics remains largely unclear. Here, four light qualities treatments(300 μmol m–2 s–1) including white fluorescent light(FL), blue monochromatic light(B, 440 nm), red monochromatic light(R, 660 nm), and a combination of red and blue light(RB, R:B=8:1) were carried out to investigate their effects on the activity of photosystem II(PSII) and photosystem I(PSI), and photosynthetic electron transport capacity in the leaves of cucumber(Cucumis sativus L.) seedlings. The results showed that compared to the FL treatment, the R treatment significantly limited electron transport rate in PSII(ETRII) and in PSI(ETRI) by 79.4 and 66.3%, respectively, increased non-light induced non-photochemical quenching in PSII(ΦNO) and limitation of donor side in PSI(ΦND) and reduced most JIP-test parameters, suggesting that the R treatment induced suboptimal activity of photosystems and inhibited electron transport from PSII donor side up to PSI. However, these suppressions were effectively alleviated by blue light addition(RB). Compared with the R treatment, the RB treatment significantly increased ETRII and ETRI by 176.9 and 127.0%, respectively, promoted photosystems activity and enhanced linear electron transport by elevating electron transport from QA to PSI. The B treatment plants exhibited normal photosystems activity and photosynthetic electron transport capacity similar to that of the FL treatment. It was concluded that blue light is more essential than red light for normal photosynthesis by mediating photosystems activity and photosynthetic electron transport capacity. | MIAO Yan-xiu W ANG Xiao-zhuo G AO Li-hong C HEN Qing-yun QU Mei | 2016 | Journal of Integrative Agriculture2016，15，1： | 9 |
| 4 | Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer显示文摘 | Zhang XM Miao XP Liang G Hao BT Wang YG Tan W Li Y Guo YL He FC Wei QY Lin DX | 2006 | 中国生物学文摘2006，20，4： | 2 |
| 5 | Photodegradation of 2,2',5,5'-tetrachlorobiphenyl in hexane 显示文摘 | Miao X S Chu S G Xu X B | 1996 | Bull Environ Contam Toxicol1996，72，4： | 1 |
| 6 | Silkworm,Bombyx mori larvae expressed the spider silk protein through a novel Bac-to-Bac/BmNPV baculovirus显示文摘 | Miao Y G Zhao A C Nakagaki M | 2006 | J Appl Entomology2006，130，5： | 1 |
| 7 | Hypoxanthine (HX) inhibition of in vitro meiotic resumption in goat oocytes 显示文摘 | Ma S Lan G Miao Y | 2003 | Mol Reprod Dev2003，66，3： | 1 |
| 8 | Muscle carnitine deficiency: adult onset lipid storage myopathy with sensory neumpathy 显示文摘 | Zhang W Miao J Zhang G | 2010 | Neurol Sci2010，31，： | 1 |
| 9 | Rapamycin alleviates brain edema af- ter focal cerebral ischemia reperfusion in rats 显示文摘 | Guo W Feng G Miao Y | 2014 | Immunopharmacol Immunotoxico12014，36，3： | 1 |
| 10 | Genetic relatedness among cultivated and wild mulberry ( Moraceae : Morus) as revealed by in-ter-simple sequence repeat (ISSR) analysis in China 显示文摘 | Zhao W G Zhou Z H Miao X X | 2006 | Can J Plant Sci2006，86，1： | 1 |
| 11 | Combinatorial characterizations of one-coincidence frequencyhopping sequences显示文摘 | CAO Z GE G~ MIAO Y | 2006 | Design Codes and Cryptography2006，41，2： | 1 |
| 12 | Cloning and expression of manganese superoxide dismutase of the silkworm,Bombyx mori by Bac-to-Bac/BmNPV Baculovirus expression system显示文摘 | Yue W F Miao Y G Nakagaki M | 2006 | Appl Microbiol Biotechnol2006，73，1： | 1 |
| 13 | Overexpression of △1-pyrroline-5-carboxylate synthetase increases proline over production and confers osmo-tolerance in transgenic plants 显示文摘 | Kavi Kishor P B K Hong Z Miao G | 1995 | Plant Physiology1995，108，4： | 1 |
| 14 | Dis- tribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada 显示文摘 | Metcalfe C D Miao Xiu Sheng Koening B G | 2003 | Environmental Toxicology And Chemistry2003，22，12： | 1 |
| 15 | An Observational and Modeling Study of Characteristics of Urban Heat Island and Boundary Layer Structures in Beijing 显示文摘 | Miao S G Chen F Lemone M A | 2009 | Journal of Applied Meteorology and Climatology2009，48，3： | 1 |
| 16 | Finite groups with some F-supplemented subgroups显示文摘 | Yi X L Miao L Zhang H G | 2010 | J Algebra and Its Applications2010，9，： | 1 |
| 17 | Distributed containment control of linear multi-agent systems 显示文摘 | Ma Q Miao G Y | 2014 | Neurocomputing2014，133，6： | 1 |
| 18 | Overexpression of Dlpyrroline-5-carboxylate synthetase increases proline production and confers osmotolerance in transgenic plants 显示文摘 | Kishor B P K Hong Z Miao G H | 1995 | Plant Physiology1995，108，： | 1 |
| 19 | Overexpression of △-Pyrroline-5-carboxylate synthetase increse proline production and confers osmotolerance in transgenic plants 显示文摘 | Hong Z Miao G H | 1987 | Plant Physiol1987，83，： | 1 |
| 20 | A comparison of genetic variation among wild and cultivated Morus species (Moraceae:Mo- rus) as revealed by ISSR and SSR markers显示文摘 | Zhao W G Zhou Z H Miao X X | 2007 | Biodivers Conser2007，16，2： | 1 |
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