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| 1 | 花椒毒素在人体皮肤及角质层中的渗透动力学探讨显示文摘目的探讨花椒毒素在人体完整皮肤及其角质层中的渗透动力学特性。方法采用人体离体皮肤及从完整皮肤中分离出的角质层,在Franz-cell扩散池中进行不同浓度的花椒毒素乙醇溶液(0.1,0.5,2.5和5.0 mg.mL-1)的渗透实验,均采用1.4%的人血清溶液作为接收液,用HPLC法测定各接收液的药物量和皮肤中的贮存药物量。结果花椒毒素乙醇溶液单位面积透过完整人皮肤速率随着浓度增加而增加,2.5 mg.mL-1以上的浓度对其速率几乎无影响。在角质层中也存在同样的现象,但其单位面积透皮速率最大值提前了约6 h。而且随着给药浓度的增加,24 h后完整皮肤和角质层的药物贮存量也相应增加,但达到一定浓度后存在饱和现象。且花椒毒素乙醇溶液在完整皮肤中的透皮时滞(0.82 h)明显大于在角质层中的透皮时滞(0.47 h)。结论该结果对开发花椒毒素外用制剂时浓度的选择提供了依据,并对其外用药物后照射长波段紫外光(UVA)的时间提供了参考。 | 王来友 Jelle Millet 黄芳芳 杨得坡 | 2006 | 药学学报2006，41，9： | 10 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | Electrochemical sodium insertion into MnCo oxide显示文摘 | BACH S MILLET M PERIERA-RAMOS J P | 1999 | Electrochemical and Solid-State Letters1999，2，： | 1 |
| 4 | Study of new catalysts based on vanadium oxide supported on mesoporous silica for the partial oxidation of methane to formaldehyde:Catalytic properties and reaction mechanism显示文摘 | NGUYEN L D LORIDANT S LAUNAY H PIGAMO A DUBOIS J L MILLET J M | | 0，，01： | 1 |
| 5 | Polymorphism in Plasmodium falciparum drug transporter proteins and reversal of in vitro chloroquine resistance by a 9,10-dihydroethanoanthracene derivative显示文摘 | Millet J Alibert S Torrentino-Madamet M | 2004 | Antimicrob Agents Chemother2004，48，12： | 1 |
| 6 | Formation of Gallium Nitride by a Novel Hot Mechanical Alloying Process显示文摘 | Millet P Calka A Williams J S | 1993 | Appl Phys Lett1993，63，： | 1 |
| 7 | J Catal显示文摘 | Kumbhar P S Sanchez-Valente J Millet J M Figueras F | 2000 | 2000,191 (2) :4672000，191，2： | 1 |
| 8 | Dihydroethanoanthracene derivatives as in vitro malarial chloroquine resista- nce reversal agents显示文摘 | Millet J Torrentino-Madamet M Alibert S | 2004 | Antimicrob Agents Chemother2004，48，7： | 1 |
| 9 | High activity of inclusion bodies formed in Escherichia coli overproducing Clostridum thermocellum endoglucanaseD显示文摘 | Tokatlidis K Dhurjati P Millet J | 1991 | FEMS Microbiol Lett1991，282，1： | 1 |
| 10 | Formation and Behaviour Study of an Environment-friendly Corrosion Inhibitor by Electrochemical Methods 显示文摘 | BOMMERSBACH P ALEMANY-DUMONT C MILLET J P | 2005 | Electrochimica Acta2005，51，6： | 1 |
| 11 | Catalytic combustion of methane on substituted barium hexaalumi- nates显示文摘 | Artizzu-Duart P Millet J M Guilhaume N | 2000 | Catalysis Today2000，59，： | 1 |
| 12 | Long-term efficacy and tolerability of flutamide combined with oral contraception in moderate to severe hirsutism:a 12-month,double-blind,parallel clinical trial显示文摘 | Calaf J Lopez E Millet A | 2007 | J Clin Endocrinol Metab2007，92，9： | 1 |
| 13 | 2007, Quantifying and comparing constitutive immunity across avian species显示文摘 | Millet S Bennett J Lee KA | 2007 | Developmental & Com- parative Immunology2007，31，2： | 1 |
| 14 | Characterization of tellurium in MoVTeNbO catalysts for propane oxidation or ammoxidation 显示文摘 | MILLET J M M ROUSSEL H PIGAMO A | 2002 | Applied Catalysis2002，232，1： | 1 |
| 15 | Mg-Fe hydrotalcite as a catalyst for the reduction of aromatic nitrocompounds with hydrazine hydrate显示文摘 | Kumbhar P S Millet J M M Figueras F | 2000 | Journal of Catalysis2000，191，2： | 1 |
| 16 | Physical and chemi-cal pretreatments for enhancing cellulose saccharification显示文摘 | Millet M A Baker A J Scatter L D | 1976 | Biotechnology&Bioengineering Symposium1976，6，： | 1 |
| 17 | Bulk oxidation state of the different cationic elements in the MoVTe(Sb)NbO catalysts for oxidation or ammoxidation of propane显示文摘 | Baca M Millet J M | 2005 | Applied Catalysis A: General2005，279，12： | 1 |
| 18 | Mg-Fe Hydrotalcite as a catalyst for the reduction of aromatic nitro compounds with hydrazine hydrate 显示文摘 | Kumbhar P S Valente J S Millet J M | 2000 | Journal of Catalysis2000，191，： | 1 |
| 19 | What are the specific computed tomography scan criteria that can predict or exclude the need for renal angioembolization after high-grade renal trauma in a conservative man- agement strategy 显示文摘 | Charbit J Manzanera J Millet I et 81 | 2011 | J Trauma2011，70，5： | 1 |
| 20 | Bacterial cellulases 显示文摘 | Beguin P Millet J Chauvaux S | 1992 | Biochemical Society Transactions1992，20，： | 1 |
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