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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | 点阵激光联合富血小板血浆治疗痤疮瘢痕显示文摘背景富血小板血浆(PRP)因其富含大量的生长因子,已经被应用于增强激光治疗痤疮瘢痕的临床疗效,但是其具体作用机制尚不得而知。目的 本研究旨在探讨PRP联合点阵激光治疗痤疮瘢痕背后的分子机制。方法 受试者的痤疮瘢痕程度从轻度到中度,采用自身对照的方法,受试者在使用点阵CO_2激光治疗后,一侧面部使用PRP辅助治疗,另一侧不使用PRP。设立患者皮肤活检状态的基线,在治疗后第1天、第3天、第7天和第28天分别获得皮肤活检标本并进行检测,研究激光联合PRP后皮肤相关变化的分子层面因素。结果 激光联合PRP治疗痤疮瘢痕的临床疗效更佳,降低了红斑、肿胀和渗出等不良反应的严重程度。 | Min S Yoon JY Park SY | 2018 | 中国医疗美容2018，8，1： | 12 |
| 3 | The valence electron structure and property analysis of TiC显示文摘The valence electron structure of TiC was calculated by using the empirical electron theory of solids and molecules. The calculated results show that with the increase of temperature the number of common electrons of TiC increases, which indicates that TiC has a good thermal stability; and there exists a close relationship between hardness and brittleness of TiC. According to the number of lattice electrons, the differences among the crystals with different structures can be explained qualitatively. Using the 'bond-strengthening factor', the differences of hardness among the crystals with different structures can also be qualitatively explained to some extent. | Wang, HR Ye, YF Min, GH Qin, JY Wang, WM | 2001 | Chinese Science Bulletin2001，46，12： | 1 |
| 4 | Helicobacter pylori infection and the CD14 (260)T geng polymorphism in ischemic stroke 显示文摘 | Park MH Min JY Koh SB | 2006 | Thrombosis Research2006，118，6： | 1 |
| 5 | Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfimction, hypertension, and proteinuria in preeclampsia显示文摘 | Maynard SE Min JY Merchan J | 2003 | J Clin Invest2003，111，5： | 1 |
| 6 | Excess placental soluble fins- like tyrosine kinase 1 ( sFltl ) may contribute to endothelial dysfunc- tion, hypertension, and proteinuria in preeclampsia 显示文摘 | Maynard SE Min JY Merchan J | 2003 | J Clin lnves- tig2003，111，5： | 1 |
| 7 | Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats显示文摘 | Min JY Yang Y Converso KL | 2002 | J Appl Physiol2002，92，： | 1 |
| 8 | Fetal sonographic diagnosis of aortic arch anomalies显示文摘 | Yoo SJ Min JY Lee YH | | 0，，05： | 1 |
| 9 | Excess placental soluble fms-like tyrosine kinase 1 (sFltl) may contribute to endothelial dysfunction, hypertension, and proteinuria in preedampsia显示文摘 | Maynard SE Min JY Merchan J | 2003 | J Clin Invest2003，111，5： | 1 |
| 10 | Biotransformation of Ginsenoside Rb1 to Prosapogenins, Gypenoside XVII, Gin- senoside Rd, Ginsenoside F2, and Compound K by Leu- conostoc mesenteroides DC102 显示文摘 | Quan LH Piao JY Min JW | 2011 | J Ginseng Res2011，35，3： | 1 |
| 11 | Excess placental soluble fms-like tyrosine kinase 1 ( sFltl ) may contribute to endothelial dysfunction, hy- pertension, and proteinuria in preeclampsia显示文摘 | Maynard SE Min JY Merchan J | 2003 | J Clin Invest2003，111，5： | 1 |
| 12 | Transplantation of embryonic stem cells improves eardiae funetion in postinfareted rats显示文摘 | Min JY Yang Y Converso KL | 2002 | J Appl Physiol2002，92，： | 1 |
| 13 | Excess placental soluble fms-like tyrosine kinase 1 (sfltl) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia 显示文摘 | Maynard SE Min JY Merchan J | 2003 | J Clin Invest2003，111，： | 1 |
| 14 | Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats 显示文摘 | Min JY Yang YK Converse KL | 2002 | J Appl Physiol2002，92，1： | 1 |
| 15 | In vivo MRI of embryonic stem cells in a mouse model of myocardial infarction显示文摘 | Himes N Min JY Lee R | | 0，，05： | 1 |
| 16 | Anti-proliferative effects of evodiamine in human lung cancer cells显示文摘 | Hong JY Park SH Min HY | 2014 | J Cancer Prev2014，19，1： | 1 |
| 17 | High expression of Snail mRNA in blood from hepatocellular carcinoma patients with extra-hepatic metastasis 显示文摘 | Min AL Choi JY Woo HY | 2009 | Clin Exp Metastasis2009，26，7： | 1 |
| 18 | Excess placental soluble Fms - like tyrosinekinase 1 ( sFlt - 1 ) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia显示文摘 | Maynard SE Min JY Merchan J Lim KH Karumanchi SA | 2003 | J Clin Invest2003，111，： | 1 |
| 19 | Novel culture technique involving an histone deacetylase inhibitor reduces the marginal islet mass to correct streptozotocin-induced diabetes显示文摘 | Shin JS Min BH Lim JY | | 0，，： | 1 |
| 20 | Atherothrombotic cerebellar infarction: vascular lesion - MRI correlation of 31 cases 显示文摘 | Min WK Kim YS Kim JY | 1999 | Stroke1999，30，11： | 1 |
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