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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 3 | Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics(英文)显示文摘OBJECTIVE: Radiation-induced meningiomas are known to occur after high and low-dose cranial radiation therapy. The goal of this study was to discern the distinguishing findings and characteristics of radiation-induced meningiomas. METHODS: The records of 16 patients (seven men and nine women) who fulfilled the criteria for radiation-induced meningiomas were retrospectively reviewed.Clinical, histopathological, cytokinetic,and cytogenetic findings as well as the patients' outcome were analyzed. The mean age of the patients was 38.8 years and the mean tumor latency was 26. 5 years. Five patients had multiple meningiomas in the irradiated field. The recurrence rate was 100% after the initial resection; 62% of patients had a second recurrence and 17% had a third recurrence. Thirtyeight percent of patients had atypical or malignant histopathological findings. The presence of progesterone receptors and low | Al-Mefty O Topsakal C Pravdenkova S Sawyer JR Harrison MJ | 2004 | 中国神经肿瘤杂志2004，2，2： | 6 |
| 4 | 尿钠和钾排泄与血压的关系显示文摘高血压影响着全球10亿人口,是死亡、脑卒中、心肌梗死、充血性心力衰竭和慢性肾损伤的主要原因。钠摄入是高血压一个可调控的决定因素。盐和血压国际性研究(international study of salt and blood pressure,INTERSALT)结果显示钠摄入和血压呈中等程度正相关[1]。然而INTERSALT不是一个足够大型的研究,其钠摄入和血压的相关性是否受地区、参与人群特征和钠或钾摄入水平影响还有待于进一步研究。 | Mente A O'Donnell MJ Rangarajan S 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，9： | 4 |
| 5 | Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia 显示文摘 | Hicks CA Ward MA Swettenham JB O'Neill MJ | 1999 | Eur J Pharmacol1999，381，23： | 2 |
| 6 | 冠状动脉钙化用于指导个性化阿司匹林治疗以预防心血管病:基于多民族动脉粥样硬化研究显示文摘最近美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)的一级预防指南建议,低剂量阿司匹林治疗仅适用于年龄40~70岁、患动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)风险较高,但出血风险不高的成年人。然而,尚不清楚如何更准确地识别出这些患者。根据2019年降低心血管病相对危险度和出血风险的阿司匹林荟萃分析研究数据,本研究旨在评估冠状动脉钙化(coronary artery calcium,CAC)在指导阿司匹林在一级预防中如何使用的价值。 | 周卫(译) 叶鹏(摘/审校) Achirica MC Miedema MD McEvoy JW Rifai MA Greenland P Dardari Z Budoff M Blumenthal RS Yeboah J Duprez DA Mortensen MB Dzaye O Hong J Nasir K Blaha MJ | 2020 | 中华高血压杂志2020，28，4： | 2 |
| 7 | Effects of CO2 pneumoperitoneum in pregnant ewes显示文摘 | Curet MJ Vogt DA Schob O | 1996 | J Surg Res1996，63，1： | 1 |
| 8 | Transeatheter closure versus medical therapy of patent foramen ovale and presumed paradoxical thromboemboli:a systematic review 显示文摘 | Khairy P O' Donnell CP Landzberg MJ | 2003 | Ann Intern Med2003，139，： | 1 |
| 9 | Long-term behavioral recovery in Pakinsonian rats by an HSV vector expressing tyrosine hydroxylase显示文摘 | Naegele JR O' Maller KL | 1994 | Science1994，266，： | 1 |
| 10 | Diagnostic accuracy of noninvasive coronary angiography using 64 slice spiral computed tomography 显示文摘 | Raft GL Gallagher MJ O'Neill WW | 2005 | J Am Coll Cardiol2005，46，3： | 1 |
| 11 | PET scanning and thehuman immunodefieiency virus-positive patient 显示文摘 | O'Doherty MJ Barrington SF Campbell M | 1997 | J Nuel Med1997，38，： | 1 |
| 12 | Synovial tissue inflammation in early and late osteoarthritis显示文摘 | Benito MJ Veale DJ FitzGerald O | 2005 | Ann Rheum Dis2005，64，9： | 1 |
| 13 | Technique of hand-assisted laparoscopic surgery显示文摘 | O'Reilly MJ Saye WB Mullins SG | 1996 | J Laparoendoscopic Surg1996，6，： | 1 |
| 14 | Diagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography显示文摘 | Raff GL Gallagher MJ O' Neill WW | 2005 | J Am Coll Cardiol2005，46，： | 1 |
| 15 | Event-related potentials as an index of cognitive function during recovery from severe closed head injury显示文摘 | Keren O Ben-Dror S Stern MJ | 1998 | J Head Trauma Rehabil(S0885-9701)1998，13，3： | 1 |
| 16 | Osteoprotegerin ligand regulates osteodast adherence to the bone sur{ace in mouse calvaria显示文摘 | O' Brien EA Wdliams JH Marshall MJ | 2000 | Biochem Biophys Res Commun2000，274，2： | 1 |
| 17 | Anterior Iliac Crest Bone Graft Harvesting Using the Corticocancellous Reamer System 显示文摘 | Westrich GH Geller DS O'Malley MJ | 2001 | J Orthop Trauma2001，15，7： | 1 |
| 18 | 18-FDG-PET as a prognostic indicator in the treatment of aggressive Non- Hodgkir s Lymphma-eomparison -ith CT显示文摘 | Mikhaee Timothy AR O' Doherty MJ | 2000 | Leuk Lympho- ma2000，39，56： | 1 |
| 19 | Induction of labor in nulli- parous women with an unfavorable cervix: a random controlled tri-al comparing double and single balloon catheters and PGE2 gel 显示文摘 | Pennell CE Henderson JJ O'Neill MJ | 2009 | BJOG2009，116，： | 1 |
| 20 | 6-hydroxydopamine-induced apoptosis is mediated via extracellular auto-oxidation and caspase 3-dependent activation of protein kinase Cδ显示文摘 | Hanrott K Gudmunsen L O'Neill MJ | | 0，，09： | 1 |
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