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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Endoscopicultrasonographyforsurveillanceofindividualsathighriskfor pancreaticcancer显示文摘Pancreatic cancer is a highly lethal disease with a ge-netic susceptibility and familial aggregation found in 3%-16% of patients. Early diagnosis remains the only hope for curative treatment and improvement of prog-nosis. This can be reached by the implementation of an intensive screening program, actually recommended for individuals at high-risk for pancreatic cancer de-velopment. The aim of this strategy is to identify pre-malignant precursors or asymptomatic pancreatic can-cer lesions, curable by surgery. Endoscopic ultrasound (EUS) with or without fine needle aspiration(FNA) seems to be the most promising technique for early de-tection of pancreatic cancer. It has been described as a highly sensitive and accurate tool, especially for small and cystic lesions. Pancreatic intraepithelial neoplasia, a precursor lesion which is highly represented in high-risk individuals, seems to have characteristics chronic pancreatitis-like changes well detected by EUS. Many screening protocols have demonstrated high diagnostic yields for pancreatic pre-malignant lesions, allowing prophylactic pancreatectomies. However, it shows a high interobserver variety even among experienced en-dosonographers and a low sensitivity in case of chronic pancreatitis. Some new techniques such as contrast-en-hanced harmonic EUS, computer-aided diagnostic tech-niques, confocal laser endomicroscopy miniprobe andthe detection of DNA abnormalities or protein markersby FNA, promise improvement of the diagnostic yield ofEUS. As the resolution of imaging improves and as ourknowledge of precursor lesions grows, we believe thatEUS could become the most suitable method to detectcurable pancreatic neoplasms in correctly identifiedasymptomatic at-risk patients. | Lami G Biagini MR Galli A | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 8 |
| 3 | 妊娠期高血压免疫因子、肿瘤坏死因子α、血管紧张素Ⅱ1型受体自身抗体对妊娠可溶性fms样酪氨酸1和可溶性Endoglin产物的影响显示文摘最近研究发现先兆子痫中血管新生因子、可溶性fms样酪氨酸激酶(sFlt-1)和可溶性Endoglin(sEn-doglin)不平衡;然而尚不清楚它们过度分泌的启动机制。方法:长期给予怀孕大鼠肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)或抗血管紧张素Ⅱ受体的自身抗体(AT1-AA),测定其循环和胎盘的sFlt-1和(或)sEndoglin以确定这些因素的免疫调节作用。 | Parrish MR Murphy SR Rutland S Wallace K Wenzel K Wallukat G Keiser S Ray LF Dechend R Martin JN Granger JP La Marca B 黄晓斌 | 2010 | 中华高血压杂志2010，18，12： | 5 |
| 4 | Longevi of fixed partial dentures 显示文摘 | Libby G Arcuri MR Lavelle WF | 1997 | J Prosthet Dent1997，78，： | 2 |
| 5 | Oral health status of dialysis patients based on their renal dialysis history in Kerman Iran 显示文摘 | Chamani G Zarei MR Radvar M Rashidfarrokhi F Razazpour F | 2009 | Oral Health Prey Dent2009，7，： | 1 |
| 6 | Ataxia with isolated vitamin E deficiency: a clinical, biochemical and genetic diagnosis显示文摘 | Alex G Oliver MR Collins KJ | 2000 | J Paediatr Child Health2000，36，5： | 1 |
| 7 | Risk Factors for Suicide in China:a National Case-control Psychological Autopsy study显示文摘 | Phillips MR Yang G Zhang Y | 2002 | The Lancet2002，30，11： | 1 |
| 8 | Effects of dietary proteins on the regulation of liver lipoprotein receptors in rats 显示文摘 | Sirtori CR Galli G Lovati MR | 1984 | J Nutr1984，114，： | 1 |
| 9 | Myocardial myocyte remodeling and fibrosis in the cardiometabolic syndrome显示文摘 | Hayden MR Chowdhury N Govindarajan G | 2006 | J Cardiometab Syndr2006，1，5： | 1 |
| 10 | Fracture ofthe capitu-lum humeri显示文摘 | Alvarez E Patel MR? Nimberg G?Pearlman HS | 1975 | J Bone Joint Surg Am1975，57，： | 1 |
| 11 | Cytokine storm in a phase 1 trial 6f the anti-CD28 monoclonal antibody TGN1412 显示文摘 | Suntharalingam G Perry MR Ward S | 2006 | N Engl J Med2006，355，10： | 1 |
| 12 | Mental practice is effective in upper limb recocery after stroke a randomized singleblind crossover study显示文摘 | Riccio I Iolascon G Barillari MR | 2010 | Eur J Phys Rehabil Med2010，46，1： | 1 |
| 13 | Immersion of cucumber fruit in heated water alters chilling-induced physiological changes 显示文摘 | MC(_X)LIMM T G IXX)STD~MR H MAYER R T | 1995 | Postharvest I~~iology and Technology1995，，6： | 1 |
| 14 | Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury显示文摘 | LIU G DETLOFF MR MILLER KN | 2012 | Exp Neurol2012，233，1： | 1 |
| 15 | Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane显示文摘 | Kuwana T Mackey MR Perkins G | 2002 | Cell2002，111，3： | 1 |
| 16 | The role of NMDA glutamate receptors,PKA,MAPK,and CAMKII in the hippocampns in extinction of conditioned fear显示文摘 | Szapiro G Vianna MR McGaugh JL Medina JH Izquierdo I | 2003 | Hippocampus2003，13，1： | 1 |
| 17 | Depression and Parkinson's disease显示文摘 | Lemke MR Fuchs G Gemende I | 2004 | J Neurol2004，2516，： | 1 |
| 18 | Intravascular ultrasound image segmentation:a three-dimensional fast-marching method based on gray level distributions显示文摘 | Cardinal MR Meunier J Soulez G | 2006 | IEEE transactions on medical imaging2006，25，5： | 1 |
| 19 | Comparsion of the sedative and amnesic effects of midazolam and propofol显示文摘 | Polster MR Gray PA O'sullivan G | 1993 | Br J Anesth1993，70，6： | 1 |
| 20 | Right ventricular pacing reduces the rate of left ventricular relaxation and filling显示文摘 | Zile MR Blaustein AS Shimizu G | 1987 | J Am coil cardiol1987，10，： | 1 |
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