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| 1 | 《过敏性鼻炎及其对哮喘的影响(ARIA)》指南2019版过敏性鼻炎管理路径(中国版)显示文摘2018年12月3日,慢性疾病管理大会在巴黎召开,经过与会的过敏科学及气道疾病领域的专家和患者组织讨论,针对未来鼻炎和哮喘的管理,推荐采用真实世界综合管理路径评估系统,旨在实现数字化、综合化、以人为本的管理。本文是该文件的摘要版,其中也介绍了中国过敏性鼻炎和哮喘的流行状况以及《过敏性鼻炎及其对哮喘的影响》(ARIA)在中国应用的具体情况。 | Bachert C Fokkens WJ Haahtela T Hellings PH Klimek L Papadopoulos N Pham-Thi N PfaarO Valiulis A Ventura MT Onorato G Czarlewski W Bedbrook A Bousquet J 王向东(编译) 王成硕(编译) 郑铭(编译) 杜崑(编译) 张罗(编译) | 2019 | 中国耳鼻咽喉头颈外科2019，26，12： | 23 |
| 2 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 3 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 11 |
| 4 | Telomerase activity in colorectal cancer,prognostic factor and implications in the microsatellite instability pathway显示文摘AIM: To determine whether the telomerase activity is related to the Microsatellite instability (MSI) genetic pathway and whether it means a difference in the survival. METHODS: The population consisted of 97 colorectal cancer patients. MSI determination was performed in accordance with the NCI criteria using PCR and Genescan. Telomerase activity was determined by the TRAP-assay, an ELISA procedure based on the amplification of telomeric repeat sequences. RESULTS: 6.2% showed high MSI (MSI-H), 10.3% showed low MSI (MSI-L) and 83.5% did not show this alteration (MSS). Positive telomerase activity was detected in 92.8% of the patients. 83.3% of MSI-H tumors showed positive telomerase against 93.8% of MSS tumors. In the overall survival analysis the absence of telomerase activity conferred a better prognosis. CONCLUSION: Previous works have shown that tumors which develop via the MSI pathway present a better prognosis. No link between telomerase activity and MSI status is observed, although sample sizes are small. Patients with telomerase negative tumors had better overall survival than patients with telomerase positive tumors. | M Vidaurreta ML Maestro S Rafael S Veganzones MT Sanz-Casla J Cerdán M Arroyo | 2007 | World Journal of Gastroenterology2007，13，28： | 8 |
| 5 | Pathogenesis of pterygium role of cytokines,growth factors, and matrix metal oproteinases 显示文摘 | di Girolamo N Chui J Coroneo MT | 2004 | Prog Retin Eye Res2004，23，2： | 1 |
| 6 | Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine 显示文摘 | Kin H Zatta A J Lofye MT | 2005 | Cardiovas Res2005，67，： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | Pathophysiology of hypertension during preeclampsia linking placental with endothelial dysfunction显示文摘 | Granger J Alexander BT Linas MT | 2001 | Hypertension2001，38，32： | 1 |
| 9 | Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?显示文摘 | Brohi K Cohen M J Ganter MT | 2007 | Ann Surg2007，245，5： | 1 |
| 10 | Treatment of stroke on an intensive stroke unit:a novel concept显示文摘 | Treib J Grauer MT Woessner R | 2000 | Intensive Care Med2000，26，： | 1 |
| 11 | Free radicals and antioxidants in normal physiological functions and human disease显示文摘 | Valko M Leibfritz D Moncol J Cronin MT Mazur M Telser J | 2007 | Int J Biochem Cell Biol2007，39，1： | 1 |
| 12 | The radiologic diagno- sis of quadriceps twndon rupture显示文摘 | Spector ED DiMm'cangelo MT Jacoby J H | 1995 | N J Med1995，92，： | 1 |
| 13 | Primary intraosseous malignant peripheral nerve sheath tumor: a case report and review of the literature显示文摘 | Khan RJ Asgher J Sohail MT | 1998 | Pathology1998，30，3： | 1 |
| 14 | Mechanical regu- lation of cell function with geometrically modulated elastomeric substrates显示文摘 | Fu J Wang Y-K Yang MT | 2010 | Nature methods2010，7，9： | 1 |
| 15 | Acute traumatic eoag- ulopathy : initiated by hypoperfusion : modulated through the protein C pathway 显示文摘 | Brohi K Cohen M J Ganter MT | 2007 | Ann Sarg2007，245，5： | 1 |
| 16 | Expression of recombi- nant human pregnancy - associated plasma protein - A and identifica- tion of the proform of eosinophil major basic protein as its physiologi- ca] inhibitor显示文摘 | Overgaard MT Haaning J Boldt HB | | J Biol Chem0，275，31： | 1 |
| 17 | Potential uses of probiotics in clinieal practice显示文摘 | Reid G Jass J Sebulskey MT | 2003 | Clin Mierobiol Revi2003，16，6： | 1 |
| 18 | Vitamin D re- ceptor gene polymorphisms and association with type 2 diabetes mellitus in a Polish population显示文摘 | Malecki MT Frey J Moczulski D | 2003 | Exp Clin En- docrinol Diabetes2003，111，8： | 1 |
| 19 | The Telemedical Res- cue Assistance System ' TemRas' -- Development, First Results, and Impact显示文摘 | BUscher C Eisner J Schneiders MT | 2014 | Biomed Eng2014，59，2： | 1 |
| 20 | Effect of an efflux pump inhibi- tor on the MIC of nalidixic acid for Acinetobacter baumannii and Stenotrophomonas mahophilia clinical isolates 显示文摘 | Ribera A Ruiz J Anta MT | 2002 | J Antimicrob Chemother2002，49，4： | 1 |
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