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| 1 | Hyperplasia vs hypertrophy in tissue regeneration after extensive liver resection显示文摘AIM To address to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. METHODS The ability of the liver to regenerate is remarkable on both clinical and biological grounds. Basic mechanisms underlying this process have been intensively investigated. However, it is still debated to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. We addressed this issue using a genetically tagged system. We were able to follow the fate of single transplanted hepatocytes during the regenerative response elicited by 2/3 partial surgical hepatectomy(PH) in rats. Clusters of transplanted cells were 3D reconstructed and their size distribution was evaluated over time after PH. RESULTS Liver size and liver DNA content were largely recovered 10 d post-PH, as expected(e.g., total DNA/liver/100 gb.w. was 6.37 ± 0.21 before PH and returned to 6.10 ± 0.36 10 d after PH). Data indicated that about 2/3 of the original residual hepatocytes entered S-phase in response to PH. Analysis of cluster size distribution at 24, 48, 96 h and 10 d after PH revealed that about half of the remnant hepatocytes completed at least 2 cell cycles. Average size of hepatocytes increased at 24 h(248.50 μm2 ± 7.82 μm2, P = 0.0015), but returned to control values throughout the regenerative process(up to 10 d post-PH, 197.9 μm2 ± 6.44 μm2, P = 0.11). A sizeable fraction of the remnant hepatocyte population does not participate actively in tissue mass restoration. CONCLUSION Hyperplasia stands as the major mechanism contributing to liver mass restoration after PH, with hypertrophy playing a transient role in the process. | Fabio Marongiu Michela Marongiu Antonella Contini Monica Serra Erika Cadoni Riccardo Murgia Ezio Laconi | 2017 | World Journal of Gastroenterology2017，23，10： | 3 |
| 2 | MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer显示文摘 | Nicola Valeri Chiara Braconi Pierluigi Gasparini Claudio Murgia Andrea Lampis Viola Paulus-Hock Jonathan R. Hart Lynn Ueno Sergei I. Grivennikov Francesca Lovat Alessio Paone Luciano Cascione Khlea M. Sumani Angelo Veronese Muller Fabbri Stefania Carasi H | 2014 | Cancer Cell2014，，： | 2 |
| 3 | A genotype-- phenotype correlation for GJB2 (connexin 26) deafness显示文摘 | Cryns K Orzan E Murgia A | 2004 | J Med Genet2004，41，： | 1 |
| 4 | Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα显示文摘 | Giulia Ranaldi Simonetta Ferruzza Raffaella Canali Guido Leoni Peter D. Zalewski Yula Sambuy Giuditta Perozzi Chiara Murgia | 2013 | The Journal of Nutritional Biochemistry2013，，6： | 1 |
| 5 | An iron-in-duced nitric oxide burst precedes ubiquitin-dependent proteindegradation for Arabidopsis AtFerl ferritin gene expression 显示文摘 | ARNAUD N MURGIA I BOUCHEREZ J | 2006 | Journal of Biological Chemistry2006，281，23： | 1 |
| 6 | Arabidopsis thaliana plants overexpressing thylakoidal ascorbate peroxidase show increased resistance to Paraquat induced photooxidative stress and to nitric oxide induced cell death显示文摘 | MURGIA I TARANTINO D VANNINI C | 2004 | Plant2004，38，6： | 1 |
| 7 | Cx26 deafness: mutation analysis and clinical variability显示文摘 | Murgia A Orzan E Polli R | 1999 | J Med Genet1999，36，： | 1 |
| 8 | Spliced and prematurely polyadenylated Jaagsiekte sheep retrovirus(JSRV)-specific RNAs from infected or transfeeted cells 显示文摘 | PALMARINI M MURGIA C A FAN H | 2002 | Virology2002，294，1： | 1 |
| 9 | Mergers and Shareholder Wealth in European Banking显示文摘 | Cyho - Ottone A Murgia M | 2000 | Journal of Banking & Finance2000，，24： | 1 |
| 10 | A Phosphatidylinositol-3-kinase(PI23K) docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential ,for envelope induced transformation of NIH-3T3 cells显示文摘 | PALMARINI M MAEDA N MURGIA C A | 2001 | J Virol2001，75，11： | 1 |
| 11 | A phosphatidylinositol 3-kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for enve- lope-induced transformation of NIH 3T3 cells 显示文摘 | Palmarini N Maeda C Murgia C | 2001 | Virology2001，75，11： | 1 |
| 12 | Arabidopsis thaliana plants overexpressing thylakoidal ascorbate peroxidase show increased resistance to Paraquat-induced photooxidative stress and to nitric oxide-induced cell death显示文摘 | Murgia I Tarantino D Vannini C | 2004 | Plant Journal2004，38，6： | 1 |
| 13 | Microdomains with high Ca2+close to IP3-sensitive channels that are sensed by neighboring mitochondria显示文摘 | Rizzuto R Brini M Murgia M | 1993 | Science1993，262，29： | 1 |
| 14 | Genetic identification of grey mullet species (Mugilidae) by analysis of mitochondrial DNA sequence:Application to identify the origin of processed ovary products ( Bottarga ) 显示文摘 | Murgia R Tola G Archer S N | 2002 | Marine Biotechnology2002，4，4： | 1 |
| 15 | Comparative bacteriostatic and bactericidal activities of cefodizime against Borrelia burgdorferi sensu lato显示文摘 | Murgia R Marchetti F Cinco M | 1999 | Antimicrob Agents Chemother1999，43，12： | 1 |
| 16 | Arabidopsis thaliana plants overexpressing thylakoidal ascorbate peroxidase show increased resistance to Paraquat-induced photooxidative stress and to nitric oxide-induced cell death显示文摘 | Murgia I Tarantino D Vannini C | 2004 | Planta2004，38，6： | 1 |
| 17 | A phosphatidylinos- itol 3 - kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope - in- duced transformation of NIH 3T3 cells显示文摘 | PALMARINI M MAEDA N MURGIA C | 2001 | J Virol2001，75，11： | 1 |
| 18 | Direct transformation of rodent fibroblasts by jaagsikte sheep retrovirus DNA显示文摘 | Palmarini M Murgia C | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 19 | Arabidopsis thali aria plants overexpressing thylakoidaI ascorhate peroxidase show increased resistance to Paraquat-induced photooxida- rive stress and to nitric oxide-induced cell death显示文摘 | Murgia I Tarantino D Vannini C | 2004 | ThePlaat Journal2004，38，6： | 1 |
| 20 | A genotype--phenotype correlation for GJB2 (connexin 26) deafness显示文摘 | Cryns K Orzan E Murgia A | 2004 | J Med Genet2004，41，： | 1 |
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