|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Protective effect of carnosol on CC14-induced acute liver damage in rats 显示文摘 | Sotelo-Felix J I Martinez-Fong D Muriel De la Torre P | 2002 | Eur J Gastroenterol Hepatol2002，14，9： | 1 |
| 3 | Meta-DiSc: a software for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 4 | Meta-DiSc:a software for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 5 | Meta-DiSc : a software for Meta- analysis of test accuracy data 显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 6 | Meta-DiSc:a softwarefor meta-analysis of test accuracy data 显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med ResMethodol2006，6，： | 1 |
| 7 | Real-time Fou- rier transformer based on fiber grating 显示文摘 | Muriel M A Azana J Carballar A | 1999 | Opt Lett1999，24，1： | 1 |
| 8 | Meta-Disc:a software for meta-analysis of test accuracy data 显示文摘 | Zarnora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，1： | 1 |
| 9 | Meta-DiSc: asoftware for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 10 | Volatile compounds in Iberian dry-cured loin显示文摘 | E Muriel T Antequera M.J Petrón A.I Andrés J Ruiz | 2004 | Meat Science2004，，3： | 1 |
| 11 | Meta-DiSc : a software for me- ta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 12 | Effects of dialyser and dialysate on the acute phase reaction in clinical bicarbonate dialysis 显示文摘 | Wilhmina EM Muriel PC Grooteman A J | 2000 | Nephrol Dinal Transplant2000，15，3： | 1 |
| 13 | Meta-DiSc:a software formeta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 14 | Volatile compounds in iberian dry-cured loin显示文摘 | Muriel E Antequera T Petrón M J | 2004 | Meat Science2004，68，3： | 1 |
| 15 | Multi-technique Monitoring of Ocean Tide Loading in Northern France显示文摘 | Muriel L Florseh N Boy J P | 2008 | C R Geoscience2008，340，6： | 1 |
| 16 | Volatile compounds in Iberian drycured loin显示文摘 | Muriel E Antequeraa T Petrbn M J | 2004 | Meat Science2004，68，3： | 1 |
| 17 | Fatty acids and triacylglycerols profiles from different types of Iberian dry-cured hams 显示文摘 | PETRON M J MURIEL E TIMON M L | 2004 | Meat Science2004，68，： | 1 |
| 18 | Meta-DiSc:a software for meta-analysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，，6： | 1 |
| 19 | Meta-DiSc:a software for metaanalysis of test accuracy data显示文摘 | Zamora J Abraira V Muriel A | 2006 | BMC Med Res Methodol2006，6，： | 1 |
| 20 | Inhibition of mitochondrial respiration by nitric oxide is independent of membrane fluidity modulation or oxidation of sulfhydryl groups 显示文摘 | PEREZ-ROJAS J M MURIEL P | 2005 | J Appl Toxicol2005，25，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员