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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Origins of cultivars of Chrysanthemum-Evidence from the chloroplast genome and nuclear LFY gene显示文摘The origins of cultivated chrysanthemums have attracted considerable attention,but they remain poorly known.Here,we reconstructed the phylogeny of representative well-known cultivars and wild species of the genus Chrysanthemum using chloroplast genomes and the nuclear LEAFY gene.Our results suggest that geographic and ecological factors may determine the opportunities for wild species to be involved in the origin of the cultivars.The wild species C.indicum,C.zawadskii,C.dichrum,C.nankingense,C.argyrophyllum,and C.vestitum were likely directly or indirectly involved as paternal species of most of the chrysanthemum cultivars examined in this study.Yet,the maternal species is supported to be a lineage of an extinct wild Chrysanthemum species and its subsequent cultivars,as all accessions of chrysanthemum cultivars sampled formed a strongly supported clade,distinct from all other species of Chrysanthemum in the plastome tree.Thus,the cultivated chrysanthemums originated from multiple hybridizations involving several paternal species rather than only two or a few wild species,with an extinct species and its subsequent cultivars serving as the maternal parents.This finding is consistent with Chrysanthemum having high rates of hybridization and gene flow,which has been demonstrated within previous studies;nevertheless,it is important to unravel the role of an extinct wild Chrysanthemum species as the ultimate maternal parent species for all the chrysanthemum cultivars.Our results also suggest that C.vestitum from Tianzhu and Funiu Mountains in Anhui and Henan Provinces of China represent two distinct cryptic species. | Yue-Ping Ma Liang Zhao Wen-Jie Zhang Ying-Hua Zhang Xia Xing Xia-Xia Duan Jing Hu AJ Harris Pei-Liang Liu Si-Lan Dai Jun Wen | 2020 | Journal of Systematics and Evolution2020，58，6： | 4 |
| 3 | 抑郁治疗和急性心肌梗死后1年死亡率的相关性:TRIUMPH注册研究显示文摘在急性心肌梗死(acute myocardial infarction,AMI)患者中,抑郁症是很普遍的,并且与不良的生活质量和预后相关。尽管一些国家组织提出了筛选抑郁症的建议,但尚不清楚AMI患者的抗抑郁治疗是否与更好的预后相关。该研究的目的是确定接受抗抑郁治疗是否对患者的预后有影响。方法: | 刘莉 叶鹏 Smolderen KG Buchanan DM Gosch K Whooley MA Chan PS Vaccarino V Parashar S Shah AJ Ho PM Spertus JA | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | Abortifacient Potential of Aqueous Extract of Senna alata Leaves in Rats显示文摘Objective To study the abortifacient activity of aqueous extract of Senna alata leaves in female Wistar rats.Methods Pregnant rats weighing 143.65 ± 13.11 g were completely randomized into 5 groups(A-E).Rats in group A(negative control) were orally administered,once daily with 0.5 ml of distilled water on days 10-18 post-coitum while those in groups B,C,D,and E were treated exactly like the negative control except they received the same volume containing 2.85 mg/kg body weight of mifepristone(group B,reference drug),250,500 and 1 000 mg/kg body weight of the extract respectively(groups C-E).Results Phytochemical screening of the extract showed positive results for saponins(1.22%),flavonoids(1.06%),cardiac glycosides(0.20%),cardenolides and dienolides(0.18%),phenolics(0.44%) and alkaloids(0.52%).Respiratory distress,salivation,diarrhoea,changes in the appearance of hair as well as maternal mortality were not observed at any time during the exposure period except in the mifepristone-treated animals where there was episode of diarrhoea and tiredness.The extract significantly reduced(P<0.05) the number of life foetus,weight and survival ratio of the foetus,numbers of implantations and Corpora lutea,implantation index,progesterone,prolactin,estradiol,follicle stimulating and luteinizing hormones whereas the number of dead foetus,number and percentage of rats that aborted,percentage vaginal opening,resorption index,pre-and post-implantation losses increased significantly.In addition,mifepristone-treated animals produced resorption index that compared well with the distilled water control.There was also no dead or life foetus and serum progesterone concentration was increased in the animals treated with mifepristone.All cases of abortion were accompanied with vaginal bleeding.Although,the final weight of the rats increased significantly,the feed and water intake were not significantly altered in all the treatment groups.The weight of the uterus,uterine-body weight ratio,length of the right uterus horn and uterine cholesterol decreased significantly in all the treatment groups.The uterine alkaline phosphatase activity and glucose concentration increased in only the extract-treated animals whereas mifepristone decreased the uterine alkaline phosphatase activity and glucose content of the animals.Conclusion This study has provided evidence to the age-long claim of S.alata leaves in 'washing the uterus'.The abortifacient properties were most pronounced at 500 and 1 000 mg/kg body weight of the extract and were similar to the animals treated with 2.85 mg/kg body weight of mifepristone.Hormonal influence,changes in implantation site,estrogenicity and uterogenicity are suggested as possible mechanism of abortifacient activity of aqueous extract of S.alata leaves.Overall,the extract may be used as an abortifacient especially at 500 and 1 000 mg/kg body weight and therefore not safe for consumption as oral remedy during pregnancy. | Yakubu MT Adeshina AO Oladiji AT Akanji MA Oloyede OB Jimoh GA Olatinwo AWO Afolayan AJ | 2010 | Journal of Reproduction and Contraception2010，21，3： | 2 |
| 5 | Thrombospondin-1 protein expression relates to good prognostic indices in dutal carcinoma in situ of the breast显示文摘 | Rice AJ Steward MA Quinn GM | 2002 | J Clin Pathol2002，55，12： | 1 |
| 6 | Cell migration: integrating signals from front to back 显示文摘 | Ridley AJ Schwartz MA Burridge K | 2003 | Science2003，302，5651： | 1 |
| 7 | Perineurioma: a clinicopathological study of eight cases 显示文摘 | Rankine AJ Filion PR Platten MA | 2004 | Pathology2004，36，4： | 1 |
| 8 | Coronary disease risk and prevalence of heart disease in primary care patients with hypertension and renal disease显示文摘 | Cosin AJ Hemandiz MA Aristegui UR | 2006 | Rev Esp Cardiol2006，59，： | 1 |
| 9 | Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately control ed with a sulphonylurea显示文摘 | Garber AJ Foley JE Banerji MA | | 0，，： | 1 |
| 10 | PI(3,4,5)P3 and PI(3,4)P2levels correlate with PKB/akt phosphorylation at Thr308 and Ser473,respectively;PI(3,4)P2 levels determine PKB activity显示文摘 | Ma K Cheung SM Marshall AJ | 2008 | Cell Signal2008，20，： | 1 |
| 11 | A multifocal electroretinograin model predicting the development of diabetic retinopathy显示文摘 | Bearse MA Jr Adams AJ Han Y Schneck ME Ng J | 2006 | Prog Retin Eye ifes2006，25，42： | 1 |
| 12 | Toxicity and metabolism of subcytotoxic inorganic arsenic in human renal proximl tubule epithelial cells(HK-2)显示文摘 | Peraza MA Carter DE Gandolfi AJ | 2003 | Cell Biol Toxicol2003，19，4： | 1 |
| 13 | An innovative pre-impregnated glass fiber reinforce composite显示文摘 | Goldberg AJ FreNch MA | | 0，，01： | 1 |
| 14 | Impact of normalized myocardial perfusion after successful angio plasty in acute myo-cardial infarction显示文摘 | Stone GW Peterson MA Lansky AJ | | 0，，39： | 1 |
| 15 | Thromboembolic disease prophylaxis in patients with hip fracture: a muhimodal approach 显示文摘 | Westrich GH Rana AJ Terry MA | 2005 | J Orthop Trauma2005，19，4： | 1 |
| 16 | Hydrogen photoproduction by Nation/cadmium sulfide/platinum films in water/sulfide ion solutions 显示文摘 | Mau AWH Huang CB Kakuta N Bard AJ Campion A Fox MA | 1984 | J Am Chem Soc1984，106，22： | 1 |
| 17 | Occlusive wound dressings in emergency medicine and acute care显示文摘 | Fonder MA Mamelak AJ Lazarus GS | 2007 | Emerg Med Clin North Am2007，25，1： | 1 |
| 18 | ICOS is critical for CD40-mediated antibody class switching显示文摘 | Greenwald RJ Levin MA | 2001 | Nature2001，409，： | 1 |
| 19 | Insulin-like growth factor binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53- independent radiation-induced apoptesis in human breast cancer cells 显示文摘 | Butt AJ Firth SM King MA | 2000 | J Biol Chem2000，275，39： | 1 |
| 20 | Reliability of a novel paradigm for determining hemispheric lateralization of visuospatial function 显示文摘 | Whitehouse AJ Badcock N Groen MA | 2009 | J Int Neuropsychol Soc2009，15，： | 1 |
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