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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Is poststroke depression a major depression显示文摘 | da Rocha e Silva CE Alves Brazil MA Matos do Nascimento E | 2013 | Cere- brovasc Dis2013，35，4： | 1 |
| 3 | Developmental changes in BDNF protein levels in the hamster retina and superior colliculus 显示文摘 | Frost DO Ma YT Hsieh T | 2001 | J Neurobiol2001，49，3： | 1 |
| 4 | Long-lasting rewarding effects of morphine induced by drug primings显示文摘 | Do Couto BR Aguilar MA Rodriguez-Arias M | 2005 | Brain Res2005，1050，： | 1 |
| 5 | 1 V 10 GHz CMOS frequency divider with low power consumption显示文摘 | Yu X P Do M A Ma J G | 2004 | IEEE Elec Lett2004，40，8： | 1 |
| 6 | Noninvasive pre- diction of tumor responses to gemcitabine using positron e- mission tomography显示文摘 | Laing RE Walte MA Campbell DO | 2009 | PNAS2009，106，8： | 1 |
| 7 | Simuha neous determination of water-soluble and fat soluble synthetic colorants in foodstuff by high-performance liquid chromatography diode array detection-electros pray mass spectrometry显示文摘 | MA Ming LUO Xu-biao CHEN Do | 2006 | Journal of Chromatogra phy A2006，11，3： | 1 |
| 8 | Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo显示文摘 | Ma SW Foster DO | 1986 | Can J Physiol Pharmacol1986，64，： | 1 |
| 9 | Extraintestinal rotavirus infections inchildren with immunodeficiency显示文摘 | Gilger MA Matson DO Conner ME | 1992 | J Pediatr1992，120，： | 1 |
| 10 | Effects of prophy-lactic continuous infusion of phenylephrine on reducing the mass oflocal anesthetic in patients undergoing spinal anesthesia for cesare-an section显示文摘 | de Souza VP do Amaral JL Tardelli MA | 2011 | Rev Bras Anestesiol2011，61，4： | 1 |
| 11 | Effect of sleep deprivation on the performance of simulated anterior segment surgical skill 显示文摘 | Erie EA Mahr MA Hodge DO | | Can J Ophthalmol0，46，1： | 1 |
| 12 | Effects of femoral neek length,stem size and body weight on strains in the proximal cement mantle显示文摘 | Harrington MA Jr O'Connor Do Lozynsky AJ | 2002 | J Bone Joint Surg Am2002，84，4： | 1 |
| 13 | Design and characterization of novel hybrid antimicrobial peptides based on cecropin A,LL-37and magainin II显示文摘 | Fox MA Thwaite JE Ulaeto DO | 2012 | Peptides2012，33，2： | 1 |
| 14 | Platelet derived exosomes of septic individuals possess proapoptotic NAD(P) H oxidase activity: A novel vascular redox pathway 显示文摘 | Janiszewski M Do Carmo AO Pedro MA | 2004 | Crit Care Med2004，32，81： | 1 |
| 15 | Blepharoplasty andbrow lift显示文摘 | Codner MA Kikkawa DO Korn BS | 2010 | Plast Reconstr Surg2010，126，1： | 1 |
| 16 | IFN - gamma is critial to the control of marine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue : a pos- sible role for nitric oxide显示文摘 | Willenborg DO Fordham SA Staykova MA | 1999 | J Immunol1999，163，10： | 1 |
| 17 | Blepharoplasty and brow lift显示文摘 | Codner MA Kikkawa DO Korn BS | 2010 | Plast Reconstr Surg2010，126，1： | 1 |
| 18 | Lund - Mackay and modified Lund Mackay score for sinus surgery in children with cystic fibrosis 显示文摘 | Do BA Lands LC Mascarella MA | 2015 | International journal of pediatric otorhinolaryngology2015，79，8： | 1 |
| 19 | Effects of femoral neek length,stemsize,and body weight on strains in the proximal cement mantle显示文摘 | Harrington MA Jr Oconner DO Lozynsky AJ | 2002 | Bone Joint Surg Am2002，84，4： | 1 |
| 20 | Effects of pharmacological inhibition of cathepsin K on fracture repair in mice 显示文摘 | Soung do Y Gentile MA Duong le T | 2013 | Bone2013，55，1： | 1 |
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