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| 1 | Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients显示文摘AIM: To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. METHODS: Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. Fecal samples were analyzed for the composition of the total microbiota using fluorescent in situ hybridization (FISH) and both fecal and duodenal brush samples were analyzed for the composition of bif idobacteria using real-time polymerase chain reaction. RESULTS: The FISH analysis of fecal samples revealed a 2-fold decrease in the level of bifidobacteria (4.2 ± 1.3 vs 8.3 ± 1.9, P < 0.01) in IBS patients compared to healthy subjects, whereas no major differences in other bacterial groups were observed. At the species level, Bifidobacterium catenulatum levels were significantly lower (6 ± 0.6 vs 19 ± 2.5, P < 0.001) in the IBS patients in both fecal and duodenal brush samples than in healthy subjects.CONCLUSION: Decreased bifidobacteria levels in both fecal and duodenal brush samples of IBS patients compared to healthy subjects indicate a role for microbiotic composition in IBS pathophysiology. | Angèle PM Kerckhoffs Melvin Samsom Michel E van der Rest Joris de Vogel Jan Knol Kaouther Ben-Amor Louis MA Akkermans | 2009 | World Journal of Gastroenterology2009，15，23： | 33 |
| 2 | 手术后胃排空紊乱显示文摘在过去的10年里,对胃进行手术的次数已明显下降。尽管如此,人们仍对讨论手术后胃排空功能紊乱十分感兴趣。在任何外科手术的头几天,都可以观察到胃排空障碍。这一情况(通常又称为手术后胃无力或手术后胃轻瘫)大多数为自限性,但也时常向外科医生提出一些严肃的问题。许多接受胃手术的病人术后晚些时候表现出的症状和体征都与残胃排空和动力紊乱有关。胃动力学病理生理知识及及胃手术后排空知识对满足病人需要的手术类型是重要的。本文对可发生于任何类型手术后(不仅仅是胃手术)的急性胃动力紊乱进行了讨论。 | Andre JPM Smout Louis MA Akkermans | 1996 | 中国实用外科杂志1996，16，5： | 4 |
| 3 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 4 | Effect of allopurinol on the survival of experimental pig flaps 显示文摘 | Louis AP Andrew MA Kerrigan CL | 1992 | Plast Reconstr Surg1992，89，6： | 1 |
| 5 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 6 | Forecast of the num- ber of patients with end-stage renal disease in the United States to the year 2010 显示文摘 | Xue JL Ma JZ Louis TA etal | 2001 | J Am Soe Nephrol2001，12，12： | 1 |
| 7 | Integrating carbon management into the development strategies Of urbanizing regions in Asia显示文摘 | Lebel Louis A Garden Po Bantaicla Ma | 2007 | Journal of Industrial Ecology2007，11，2： | 1 |
| 8 | ARPP-16 mRNA is up- regulated in the longissimus muscle of pigs possessing an elevated growth rate显示文摘 | Janzen MA Kuhlers DL Jungst SB Louis CF | 2000 | J Anim Sci2000，78，6： | 1 |
| 9 | Forecast of the number of patients with end -stage renal disease in the United States to the year 2010 显示文摘 | Xue JL Ma JZ Louis TA | 2001 | J Am Soc Nephro12001，2，12： | 1 |
| 10 | High-Harmonic Generation and Correlated Electron Emission from Relativistic Plasma Mirrors at 1 kHz Repetition Rate显示文摘We report evidence for the first generation of XUV spectra from relativistic surface high-harmonic generation(SHHG)on plasma mirrors at a kilohertz repetition rate,emitted simultaneously with energetic electrons.SHHG spectra and electron angular distributions are measured as a function of the experimentally controlled plasma density gradient scale length Lg for three increasingly short and intense driving pulses:24 fs and a0=1:1,8 fs and a0=1:6,and finally 4 fs and a0≈2:1,where a0 is the peak vector potential normalized by mec/e with the elementary charge e,the electron rest mass me,and the vacuum light velocity c.For all driver pulses,we observe correlated relativistic SHHG and electron emission in the range Lg∈½λ/20,λ/4,with an optimum gradient scale length of Lg≈λ/10.This universal optimal Lg-range is rationalized by deriving a direct intensity-independent link between the scale length Lg and an effective similarity parameter for relativistic laser-plasma interactions. | Stefan Haessler Marie Ouillé Jaismeen Kaur Maïmouna Bocoum Frederik Böhle Dan Levy Louis Daniault Aline Vernier Jérôme Faure Rodrigo Lopez-Martens | 2022 | Ultrafast Science2022，，3： | 1 |
| 11 | Forecast of the number of patients with end-stage renal disease in the United States to the year 2010显示文摘 | Xue JL Ma JZ Louis TA | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 12 | Forecast of the number ofPatients with end - stage renal disease in the United States to theyear 2010 显示文摘 | XUE J L MA J Z LOUIS T A | 2010 | J Am Soc Nephrol2010，12，12： | 1 |
| 13 | Forecast of the number of patients with end-stage renal disease in the United States to the year 2010显示文摘 | Ma J Z Louis T A | 2001 | J Am Soc Nephrol2001，12，12： | 1 |
| 14 | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease显示文摘 | Denis MA Louis R Malaise M | 2001 | Scand J Gastroenterol2001，36，2： | 1 |
| 15 | Forecast of the number of patients with end-stage renal disease in the United States to the year 2010显示文摘 | Xue JL Ma JZ Louis TA | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 16 | Organochlorine pesticides and endometriosis显示文摘 | Cooney MA Buck Louis GM | 2010 | Reprod Toxicol2010，30，3： | 1 |
| 17 | Forecast of the number of patients with end - stage rena disease in the United States to the year 2010显示文摘 | Xue JL Ma JZ Louis TA | 2001 | J Am Soc Nephro12001，12，12： | 1 |
| 18 | Forecast of the number of patients with end stage renal disease in the Unitd Statets to the year 2010显示文摘 | Xue JL Ma JZ Louis TA | 2001 | J Am Soc Nephrol2001，12，12： | 1 |
| 19 | Association of obesity with hiatal hernia and esophagitis显示文摘 | Louis J Wilson Wenzhou Ma M.S Basil I Hirschowitz | 1999 | The American Journal of Gastroenterology1999，，10： | 1 |
| 20 | Dentritic hyperbranched polymers as tougheners for epoxy resins 显示文摘 | Boogh Louis Pettersson Bo Ma nson J-AE | 1999 | Polymer1999，40，9： | 1 |
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