|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Insights into gastric neuroendocrine tumors burden显示文摘Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors. | Taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de Assumpcao | 2017 | Chinese Journal of Cancer Research2017，29，2： | 7 |
| 3 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 4 | Comparison of two clinical scales for causality assessment in hepatotoxicity显示文摘 | Ma Isabel Lucena Raquel Camargo Raúl J. Andrade Carlos J. Perez-Sanchez Felipe Sanchez De La Cuesta | 2001 | Hepatology2001，，1： | 2 |
| 5 | Increased heritability of certain types of anorectal malformations 显示文摘 | Falcone RA Jr Levitt MA Pena A | 2007 | J Pediatr Surg2007，42，1： | 1 |
| 6 | Histopathological changes in the wall of varicose veins显示文摘 | Wali MA Dewan M Eid RA | 2003 | Int Angiol2003，22，2： | 1 |
| 7 | Simvastatin Reduces Expression of Cytokmes Interleukin-6, Interteukin-8, and Monocyte Chemoattractant Protein-1 in Circulating Monocytes From Hypercholesterolemic Patients 显示文摘 | Rezaie MA Maca T Bucek RA | 2002 | Arterioscler Thromb VscBiol2002，22，7： | 1 |
| 8 | Toll-like receptor 2 is re-quired for innate, butnot acquired, host defense to Borrelia buzgdoifen显示文摘 | WootenRM Ma Y Yoder RA | 2002 | Immunol2002，168，1： | 1 |
| 9 | Review of 1027 Patients With Newly Diagnosed Multiple Myeloma显示文摘 | Kyle RA Gertz MA Witzig TE | | 0，，： | 1 |
| 10 | Tumour invasion and metastasis initiated by microRNA-10b in breast cancer显示文摘 | Ma L Teruya-Feldstein J Weinberg RA | 2007 | Nature2007，449，7163： | 1 |
| 11 | Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity 显示文摘 | Shanely RA Zergeroglu MA Lennon SL | 2002 | Am J Respir Crit Care Med2002，166，10： | 1 |
| 12 | Randomized comparison and economic evaluation of laparoscopic assisted hysterectomy and abdominal hysterectomy显示文摘 | LUMSDEN MA TWADDLE S HAWTHORN RA | 2000 | B JOG2000，107，11： | 1 |
| 13 | Tumour invasion and metastasis initiated by microRNA-10b in breast cancer 显示文摘 | Ma L Teruya-Feldstein J Weinberg RA | 2007 | Nature2007，449，7163： | 1 |
| 14 | Ribosomal DNA spacer-length polymorphisms in barley:mendelian inheritance,chromosomal location and population dynamics显示文摘 | Saghai-Maroof MA Soliman KM Jorgensen RA | 1984 | Proc Nati Acad Sci USA1984，81，： | 1 |
| 15 | Role of reactive oxygen species in the pathophysiology of human reproduction显示文摘 | AGARWAL A SALEH RA BEDAIWY MA | 2003 | Fertil Steril2003，79，4： | 1 |
| 16 | POEMS syndrome: definition and long-term outcome 显示文摘 | Dispenzieri A Kyle RA Lacy MA | 2003 | Blood2003，101，7： | 1 |
| 17 | Evaluation of progenitor cell cultures from human embryos for neurotransplantation显示文摘 | Marey MV Aleksandrova MA | 2002 | Dev Brain Res2002，134，： | 1 |
| 18 | Ultraviolet lighting during orthopaedic surgery and the rate of infection显示文摘 | Ritter MA Olberding EM Malinzak RA | 2007 | J Bone Joint Surg Am2007，89，9： | 1 |
| 19 | Association between alcohol consumption and insulin sensitivity and cardiovascular disease risk ractors:the Insulin Resistance and Atherosclerosis Study显示文摘 | Bell RA Mayer-Davis EJ Martin MA | 2000 | Diabetes Care2000，23，11： | 1 |
| 20 | Use of cone-beam volumetric tomography in the diagnosis of root fractures显示文摘 | Bernardes RA de Moraes IG Húngaro Duarte MA | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009，108，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员