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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | Management of autoimmune hepatitis:Focus on pharmacologic treatments beyond corticosteroids显示文摘In autoimmune hepatitis, patients who are intolerant or with toxicity experience, non-responders, relapsers or refractory are challenging. Non-standard drugs are being tried to preemptively avoid corticosteroid-related side effects. Prognosis and quality of life of life rely on treatment optimization. Recently, emergence of powerful immunosuppressive agents, mainly from liver transplantation, challenged the supremacy of the corticosteroid regime and promise greater immunosuppression than conventional medications, offer site-specific actions and satisfactory patient tolerance. Successes in experimental models of related diseases have primed these molecular interventions. We performed a literature review on alternative treatments. Azatioprine intolerance is the principal indication for mycophenolate use butit can be used as a front-line therapy. Cyclosporine A and tacrolimus have been tested for non-responders or relapsers. Rituximab may be used as salvage therapy. Anti-tumor necrosis factor-alpha agents may be used for incomplete responses or non-responders. Methotrexate is possibly an alternative for induction of remission and maintenance in refractory patients. Cyclophosphamide has been included in the induction regimen with corticosteroids. Ursodeoxycholic acid action is mainly immunomodulatory. Non-standard treatments are coming slowly to the attention, but its use should be cautious performed by experienced centers. | Marta Casal Moura Rodrigo Liberal Hélder Cardoso Ana Maria Horta e Vale Guilherme Macedo | 2014 | World Journal of Hepatology2014，6，6： | 2 |
| 3 | Carbon and nitrogen mineralization in soils under agro-pastoral systems in subtropical central Brazil显示文摘 | Kanda K Miranda C H B Macedo M C M | 2002 | Soil Science and Plant Nutrition2002，48，2： | 1 |
| 4 | Ten years’minimum follow-up with the ileal continent catheterizable reservoir:A test of time显示文摘 | Macedo A Jr E Damazio H Bacelar A | 2013 | J Pediatr Urol2013，9，3： | 1 |
| 5 | A Quantum Chemical and Photophysical Study of Acridine-9-N-Methacrylamide显示文摘 | Camargo A J Macedo L G M D | 2004 | J Mol Struct2004，674，： | 1 |
| 6 | A rule-based adaptive routing protocol for continuous data dissemination in WSNs显示文摘 | Daniel F Macedo Luiz H A Correia | 2006 | Journal of Parallel and Distributed Computing2006，66，4： | 1 |
| 7 | Role of magnetic resonance imaging in arrhythmogenic right ventricular dysplasia:insights from the North American arrhythmogenic right ventricular dysplasia (ARVD/C) study显示文摘 | Tandri H Macedo R Calkins H | 2008 | Am Heart J2008，155，14： | 1 |
| 8 | Generalised free-volume theory for transport properties and new trends about the relationship between free volume and equations of state显示文摘 | Liu H Q Silva C M Macedo E A | 2002 | Fluid Phase Equilibria2002，202，1： | 1 |
| 9 | The spreading of cobalt, nickel and iron on tungsten carbide and the first stage of hard metal sintering显示文摘 | Macedo H R Silva A G P Melo D M A | 2003 | Materials Letters2003，57，2425： | 1 |
| 10 | Gross alpha-and beta-activities in surface and ground water of Rio Grande do Norte, Brazil 显示文摘 | Malanca A Repetti M De Macedo H R | 1998 | Ap- pl Radiat Isot1998，49，： | 1 |
| 11 | Infraorbital foramen location in dry human skulls 显示文摘 | Macedo VC Cabrini RR Faig Leite H | 2009 | Braz J Morphol Sci2009，26，1： | 1 |
| 12 | Urethral duplication II-A Y type with rectal urethra: ASTRA approach and tunica vaginalis flap for first stage repair显示文摘 | Macedo A Jr Rondon A Bacelar H | 2012 | Int Braz J Urol2012，38，70： | 1 |
| 13 | Transbronchoscopic pulmonary emphysema treatment : 1 - month to 24 - month endoscopic follow - up 显示文摘 | DE OLIVEIRA H G MACEDO NETO A V JOHN A B | 2006 | Chest2006，130，1： | 1 |
| 14 | Interleukin-4 modu- lates the inflammatory response in ifosfamide-induced hemorrhagic cystitis显示文摘 | Macedo F Y Mour~o L T Freitas H C | 2012 | Inflammation2012，35，1： | 1 |
| 15 | Effect of residual herbicides on in vitro development of the fungus causing Fusarium disease of cotton显示文摘 | de Macedo E C Garcia B H Chiba S | 1984 | Biologico1984，50，5： | 1 |
| 16 | Postnasal drip and chronic cough : A open interventional study 显示文摘 | Macedo P Saleh H Torrego A | 2009 | Respir Med2009，，103： | 1 |
| 17 | Immunoregulatory properties of rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation显示文摘 | Macedo C Turquist H Metes D | | 0，，1： | 1 |
| 18 | Generalised Free-Volume Theory for Transport Properties and New Trends About the Relationship Between Free Volume and Equations of State 显示文摘 | Liu H Silva C M Macedo E A | 2002 | Fluid Phase Equilibria2002，202，： | 1 |
| 19 | Transmission power control techniques for wireless sensor networks显示文摘 | Correia L H A Macedo D F | 2007 | Computer Networks2007，51，6： | 1 |
| 20 | Effect of load partition and particle distribution on micro-abrasive wear mapping of two-phase metal matrix composites 显示文摘 | GAVA G H S SOUZA R M D de MELLO J D B de MACEDO M C S SCANDIAN C | 2013 | Wear2013，301，1： | 1 |
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