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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | identification of the 72- kDa(MMP - 2)and 92 - kDa(MMP - 9)gelatinase type iv collar - genase in preparations of laminin and Matrigel 显示文摘 | Mackay A R Gomez D E Cottam D W | 1993 | Biotech - niques1993，15，： | 1 |
| 3 | The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis显示文摘 | Douglas R Mackay Suzanne W | 2009 | Molbiolcell2009，20，6： | 1 |
| 4 | Impacts of input parameter spa-tial aggregation on an agricultural nonpoint source pollutionmodel显示文摘 | Fitzhugh T W Mackay D S | 2000 | Journal of Hydrology2000，236，： | 1 |
| 5 | Impacts of input parameter spatial aggregation on agricultural non-point source pollution model显示文摘 | FITZHUGH T W MACKAY D S | 2000 | Journal of Hydrology2000，236，： | 1 |
| 6 | Event-related potential evidence for frontal cortex effects of chronic cocaine dependence显示文摘 | MacKay S Clark W | 1997 | Biol Psychiatry1997，42，： | 1 |
| 7 | Multiple sclerosis and autoimmune diseases 显示文摘 | BAKER H W BALLA J I MACKAY I R | 1972 | Aus N Z J Med1972，2，： | 1 |
| 8 | An analysis of simulated and observed global mean near - surface air temperature anomalies from 1979 to 1999: Trends and attribution of causes 显示文摘 | MacKay R M Ko M K W | 2001 | Chemosphere - Global Change Science2001，3，4： | 1 |
| 9 | A multicenter pilot external quality assessment programme to assess the quality of molecular detection of Chlamydophila pneumoniae and Mycoplasma pneu- moniae显示文摘 | Loens K Mackay W G Scott C | 2010 | J Microbiol Meth2010，82，2： | 1 |
| 10 | Development of high-manganese steels for heavy duty cast-to-shape applications显示文摘 | SMITH R W DEMONTE A MACKAY W B F | 2004 | J Mater Process Technol2004，153，： | 1 |
| 11 | Impacts of input parameter spatial aggregation on an agricultural non-point source pollution model显示文摘 | Fitzhugh T W Mackay D S | 2000 | Journal of Hydrology2000，236，12： | 1 |
| 12 | Second-line or subsequent systemic therapy for recurrent or progressive non-small cell lung cancer:a systematic review and practice guideline显示文摘 | Noble J Ellis P M Mackay J A Evans W K | 2006 | J Thorac Oncol2006，1，： | 1 |
| 13 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 14 | Uptake of organic chemicals by plants:A review of processes,correlations and models显示文摘 | Paterson S Mackay D Tam D Shiu W Y | 1990 | Chemosphere1990，21，3： | 1 |
| 15 | From mutations to MAGIC: resources for gene discovery, validation and delivery in crop plants 显示文摘 | Cavanagh C Morell M Mackay I Powell W | 2008 | Current Opinion in Plant Biology2008，11，2： | 1 |
| 16 | Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes显示文摘 | Boule M W Broughton C Mackay F | 2004 | J Exp Med2004，199，12： | 1 |
| 17 | Controlled atmosphere storage of rabbiteye blueberries enhances postharvest quality aspects显示文摘 | SCHOTSMANS W MOLAN A MACKAY B | 2007 | Postharvest Biol Technol2007，44，： | 1 |
| 18 | A critical review of aqueous solubilities, vapor pressures, Henry's Law constants and octano-water partition coefficients of the polychlorinated biphenyls 显示文摘 | Shiu W Y Mackay D 1986 | 1986 | Journal of Physics and Chemistry Reference Data1986，15，： | 1 |
| 19 | Rate of Evaporation of Low - Solubility Contami- nants from Water Bodis to Atmosphere 显示文摘 | Mackay D Wolkoff A W | 1973 | Environment Science and Technol- ogy1973，，： | 1 |
| 20 | Recent advandes in understanding lignin biosynthesis显示文摘 | Whetten R W MacKay J J Sederoff R R | 1998 | Annu Rev Plant Physiol Plant MoLBiol1998，，49： | 1 |
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