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| 1 | Influence of bioactive sulphated polysaccharide-protein complexes on hepatocarcinogenesis, angiogenesis and immunomodulatory activities显示文摘Objective:To explore the in vivo anticancer,anti-angiogenesis and immunomodulatory efficacies of the bioactive polysaccharide isolated from cold aqueous extract of Jania rubens(JCEM) and Pterocladia capillacea(PCEM) as well as hot aqueous extract of Enteromorpha intestinalis(EHEM) against hepatocellular carcinoma rat model(HCC) and to study their chemical composition.Methods:The sugars and amino acids composition of the bioactive polysaccharides of JCEM,PCEM and EHEM were determined using gas liquid chromatography and amino acid analyzer,respectively.These polysaccharide extracts(20 mg/kg b.wt.for 5 weeks) were assessed on hepatocarcinogenesis in rats and α-fetoprotein(AFP),carcinoembryonic antigen(CEA),glypican-3(GPC-3),hepatocyte growth factor(HGF) and vascular endothelial growth factor(VEGF) and Ig G levels were evaluated.Results:The GLC analysis of JCEM,PCEM and EHEM polysaccharide revealed the presence of 10,9 and10 sugars,in addition the amino acid analyser enable identification of 16,15 and 15 amino acids,respectively.These polysaccharide extracts of JCEM,PCEM and EHEM produced significant decrease in serum AFP,CEA,GPC-3,HGF and VEGF compared with untreated HCC group.JCEM,PCEM and EHEM had an immunostimulatory responses by increasing the IgG levels as compared by naive value(1.23,1.53 and 1.17 folds),respectively.The bioactive polysaccharides in HCC induced rats improved the humoral immune response.The photomicrographs of liver tissue sections of the groups of HCC treated with polysaccharide extracts of Jania rubens and Enteromorpha intestinalis showed intact histological structure.Moreover,fractions HE1,HE4,HE7 obtained from polysaccharide of EHEM showed moderate cytotoxic activity against Hep G2 in vitro with IC_(50) 73.1,42.6,76.2 μg/mL.However,fractions of PCEM and JCEM show no or weak cytotoxicity against Hep G2 in vitro where the cytotoxic activity of their crude polysaccharide extract proved synergetic effect.Conclusions:The pronounced antitumor activity of sulphated polysaccharide-protein complexes of JCEM and EHEM is due to direct cytotoxic activity,anti-hepatocarcinogensis,and anti-angiogenesis.In addition,JCEM,PCEM and EHEM had an immunostimulatory response and improved the humoral immune response in HCC induced rats. | Azza A.Matloub Hadeer A.Aglan Sahar Salah Mohamed El Souda Mona Elsayed Aboutabl Amany Sayed Maghraby Hanaa H.Ahmed | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 7 |
| 2 | Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern显示文摘 | H.M. El Tayebi K. Omar S. Hegy M. El Maghrabi M. El Brolosy K.A. Hosny G. Esmat A.I. Abdelaziz | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 2 |
| 3 | Excimer laser in situ keratomileusis under a corneal flap for myopia of 2 to 20 diopters显示文摘 | Salah T Waring Ⅲ Go Maghraby A | 1996 | Am J Ophthalmol1996，121，2： | 1 |
| 4 | Excimer laser in situ keratomileusis under a cornea frap for myopia of 2 to 20 diopters 显示文摘 | Salan T Waringg G Maghraby A | 1996 | Am J Ophthalmol1996，121，： | 1 |
| 5 | Automated in situ keratomileusis for myopia 显示文摘 | Ibrahim O Waring GO Salah T el Maghraby A | 1995 | J Refract Surg1995，11，6： | 1 |
| 6 | In situ extracorporeal shock-wave lithotripsy as a primary treatment for ureteral stones显示文摘 | Maghraby H | 2003 | Ann Saudi Med2003，23，12： | 1 |
| 7 | Occlusive and non-occlusive application of microemulsion for transdermal delivery of progesterone: mechanistic studies 显示文摘 | MAGHRABY G M E | 2012 | Sci Pharm2012，80，3： | 1 |
| 8 | Management of button battery stricture in 22-day-old neonate显示文摘 | RABOEI E H SYED S S MAGHRABi M | 2009 | Eur J Pediatr Surg2009，19，： | 1 |
| 9 | Assessment of convergenceangles of tooth preparations for complete crowns among dentalstudents显示文摘 | Ayad MF Maghrabi AA Rosenstiel SF | 2005 | Dent2005，33，8： | 1 |
| 10 | Interactions of surfactants (edge activators) and skin penetration enhancers with liposomes显示文摘 | El Maghraby G M Williams A C Barry B W | 2004 | Int J Pharm2004，276，12： | 1 |
| 11 | Interactions of surfactants (edge activators )and skin penetration enhancers with liposome 显示文摘 | MAGHRABY G M WILLIMS A C BARRY B W | 2004 | Int J Pham2004，276，12： | 1 |
| 12 | Skin delivery of estradiol from deformable and traditional liposomes:mechanistic studies显示文摘 | El MAGHRABY GM WILLIAMS AC BARRY BW | 1999 | J Pharm Pharmacol1999，51，10： | 1 |
| 13 | 3rd Excimer laser photo- therapeutic keratectomy before cataract extraction and intraocu- lar lens implantation 显示文摘 | Salah T el Maghraby A Waring GO | 1996 | Am J Ophthalmol1996，122，3： | 1 |
| 14 | Phase transition water-in-oil microemulsions as ocular drug delivery system: in vitro and in vivo evaluation显示文摘 | Judy Chan Gamal MM El Maghraby | 2007 | Int J Pham2007，328，1： | 1 |
| 15 | Estradiol skin delivery from ultradeformable liposomes:refinement of surfactant concentration显示文摘 | EL MAGHRABY GM WILLIAMS AC BARRY BW | 2000 | Int J Pharm2000，196，1： | 1 |
| 16 | Oestradiol skin delivery from ultradeformable liposome: refinement of surfactant concentration 显示文摘 | Maghraby E Adrian C | 2000 | Int J Pharm2000，196，5： | 1 |
| 17 | Accumulation of cadmium, lead and strontium and a role of calcium oxalate in water hyacinth tolerance 显示文摘 | MAZEN A MAGHRABY O | 1997 | Biological Plant arum1997，40，： | 1 |
| 18 | Skin hydration and possible shunt route penetration in controlled estradiol delivery from ultradeformable and standard liposomes显示文摘 | EL MAGHRABY GM WILLIAMS AC BARRY BW | 2001 | J Pharm Pharmacol2001，53，10： | 1 |
| 19 | Skin delivery of oestradiol from lipid vesicles:impoaanee of liposome structure显示文摘 | MAGHRABY GM WILLIAMS AC BARRY BW | 2000 | Int J Pharm2000，204，12： | 1 |
| 20 | Skin delivery of 5-fluorouracil from ultradefor mable and standard liposomes in vitro显示文摘 | EL MAGHRABY GM WILLIAMS AC BARRY BW | 2001 | J Pharm Pharmacol2001，53，8： | 1 |
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