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| 1 | Schwann cell development,maturation and regeneration:a focus on classic and emerging intracellular signaling pathways显示文摘The development,maturation and regeneration of Schwann cells(SCs),the main glial cells of the peripheral nervous system,require the coordinate and complementary interaction among several factors,signals and intracellular pathways.These regulatory molecules consist of integrins,neuregulins,growth factors,hormones,neurotransmitters,as well as entire intracellular pathways including protein-kinase A,C,Akt,Erk/MAPK,Hippo,mTOR,etc.For instance,Hippo pathway is overall involved in proliferation,apoptosis,regeneration and organ size control,being crucial in cancer proliferation process.In SCs,Hippo is linked to merlin and YAP/TAZ signaling and it seems to respond to mechanic/physical challenges.Recently,among factors regulating SCs,also the signaling intermediates Src tyrosine kinase and focal adhesion kinase(FAK)proved relevant for SC fate,participating in the regulation of adhesion,motility,migration and in vitro myelination.In SCs,the factors Src and FAK are regulated by the neuroactive steroid allopregnanolone,thus corroborating the importance of this steroid in the control of SC maturation.In this review,we illustrate some old and novel signaling pathways modulating SC biology and functions during the different developmental,mature and regenerative | Luca Franco Castelnovo Veronica Bonalume Simona Melfi Marinella Ballabio Deborah Colleoni Valerio Magnaghi | 2017 | Neural Regeneration Research2017，12，7： | 9 |
| 2 | Senescence in adipose-derived stem cells and its implications in nerve regeneration显示文摘Adult mesenchymal stem cells,specifically adipose-derived stem cells have self-renewal and multiple differentiation potentials and have shown to be the ideal candidate for therapeutic applications in regenerative medicine,particularly in peripheral nerve regeneration.Adipose-derived stem cells are easily harvested,although they may show the effects of aging,hence their potential in nerve repair may be limited by cellular senescence or donor age.Cellular senescence is a complex process whereby stem cells grow old as consequence of intrinsic events(e.g.,DNA damage)or environmental cues(e.g.,stressful stimuli or diseases),which determine a permanent growth arrest.Several mechanisms are implicated in stem cell senescence,although no one is exclusive of the others.In this review we report some of the most important factors modulating the senescence process,which can influence adipose-derived stem cell morphology and function,and compromise their clinical application for peripheral nerve regenerative cell therapy. | Cristina Mantovani Giorgio Terenghi Valerio Magnaghi | 2014 | Neural Regeneration Research2014，9，1： | 6 |
| 3 | Gene expression changes in dorsal root ganglia following peripheral nerve injury: roles in inflammation,cell death and nociception显示文摘Subsequent to a peripheral nerve injury, there are changes in gene expression within the dorsal root ganglia in response to the damage. This review selects factors which are well-known to be vital for inflammation, cell death and nociception, and highlights how alterations in their gene expression within the dorsal root ganglia can affect functional recovery. The majority of studies used polymerase chain reaction within animal models to analyse the dynamic changes following peripheral nerve injuries. This review aims to highlight the factors at the gene expression level that impede functional recovery and are hence are potential targets for therapeutic approaches. Where possible the experimental model, specific time-points and cellular location of expression levels are reported. | Sarah L.Martin Adam J.Reid Alexei Verkhratsky Valerio Magnaghi Alessandro Faroni | 2019 | Neural Regeneration Research2019，14，6： | 4 |
| 4 | Po gene expression is modulated by androgens in the sciatic nerve of adult male rats显示文摘 | Magnaghi V Cavarretta I Zucchi I | 1999 | Brain Res Mol Brain Res1999，70，1： | 1 |
| 5 | Aging in peripheral nerves:regulation of myelin protein genes by steroid hormones显示文摘 | Melcangi R C Magnaghi V Martini L | 2000 | Prog Neurobiol2000，60，3： | 1 |
| 6 | Architectural (Type ⅠA) focal cortical dysplasia and parvalbumin immunostaining in temporal lobe epilepsy 显示文摘 | Garbelli R Meroni A Magnaghi G | 2006 | Epilepsia2006，47，6： | 1 |
| 7 | Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regenera- tion 显示文摘 | Magnaghi V Procacci P Tata AM | 2009 | Int Rev Neurobiol2009，87，： | 1 |
| 8 | Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain显示文摘 | Magnaghi V Castelnovo LF Faroni A | 2014 | Bio Med Research International2014，2014，36： | 1 |
| 9 | Architectural (Type IA) focal cortical dysplasia and parvalbumin im- munostaining in temporal lobe epilepsy 显示文摘 | Garbelli R Meroni A Magnaghi G | 2006 | Epilepsia2006，47，6： | 1 |
| 10 | Durability of epoxy resin-based materials for the repair of damaged cementitious composites 显示文摘 | Saccani A Magnaghi V | 1999 | Cement and Concrete Research1999，29，： | 1 |
| 11 | Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells 显示文摘 | Magnaghi V Veiga S Ballabio M | 2006 | J Periph Nerv Sys2006，11，2： | 1 |
| 12 | Characterization by yeast artifici al chromosome cloning of the linked apolipoprotein(a) and plasminogen genes and identification of the apolipoprotein(a) 5' flanking region 显示文摘 | Acquati F Magnaghi P | 1992 | Proc Natl Acad Sci USA1992，89，11： | 1 |
| 13 | Perineuronal satellite cells in mouse spinal ganglia express the gap junction protein connexin43 throughout life with decline in old age 显示文摘 | Procacci P Magnaghi V Pannese E | 2008 | Brain Res Bull2008，75，5： | 1 |
| 14 | Durability of Epoxy Resin-Based Materials for the Repair of Damaged Cementitious Composites显示文摘 | Andrea Saccani Vittorio Magnaghi | 1999 | Cement and Concrete Research1999，29，： | 1 |
| 15 | Corticosteroids protect oligodendrocytes from cytokine-induced cell death显示文摘 | Melcangi RC Cavarretta I Magnaghi V | 2000 | Neuroreport2000，11，18： | 1 |
| 16 | HIBA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3 显示文摘 | Magnaghi P Roberts C Lorain S | 1998 | Nat Genet1998，20，1： | 1 |
| 17 | Metabotropic receptors for glutamate and GABA in pain显示文摘 | Goudet C Magnaghi V Landry M | 2009 | Brain Res Key2009，60，1： | 1 |
| 18 | Membrane progesterone receptors(mPRs/PAQRs)in Schwann cells represent a promising target for the promotion of neuroregeneration显示文摘Schwann cells and neuroregeneration:Peripheral nerve injury is a common cause of morbidity,which affects millions of people worldwide.The peripheral nervous system,differently from the central nervous system,has an intrinsic ability to regenerate after injury.However,in most cases the regenerative outcome is not completely satisfactory,in particular for long-gap peripheral nerve injuries in which the microsurgical approach is not possible.In these cases。 | Luca F.Castelnovo Peter Thomas Valerio Magnaghi | 2021 | Neural Regeneration Research2021，16，2： | 1 |
| 19 | Effects of steroid hormones on gene expression of glial markers in the central and peripheral nervous system:variations induced by aging显示文摘 | Melcang RC Magnaghi V Cavarretta I | 1998 | Exp Gerontol1998，33，78： | 1 |
| 20 | Progesterone derivatives in- crease expression of Krox-20 and Sox-10 in rat Schwann cells 显示文摘 | Magnaghi V Ballabio M Roglio I | 2007 | J Mol Neurosci2007，31，2： | 1 |
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