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| 1 | Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum显示文摘We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum.A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss.On computed tomography(CT) a wall thickening of the fourth part of the duodenum was observed.Multiple biopsies obtained from the lesion showed inflltration of plasma cells and lymphocytes, but they were not conclusive.The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse inflltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria.An extensive deposition of amyloid was also observed.Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ light chain positive.These cells also were positive for CD138 and CD56 but negative for CD20 and CD79.The flndings were consistent with extramedullary plasmocytomaassociated with a massive deposit of amyloid in duodenum.A subsequent workup for multiple myeloma was completely negative.The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up.Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future. | Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira Lívia Bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida Prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira Lopes | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 2 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 3 | Synthesis of utility systems by simulated显示文摘 | Maia L O A Vidal L A Qassim R Y | 1995 | Comp & Chem Eng1995，19，： | 1 |
| 4 | Infinitely many nodal solutions for a weakly coupled nonlinear Schr6dinger system 显示文摘 | Maia L A Montefuseo E Pellacci B | 2008 | Communications in Contemporary Mathematics2008，10，5： | 1 |
| 5 | Improving Water-efficient Irrigation: Prospects and Difficulties of In- novative Practices 显示文摘 | LEVIDOW L ZACCARIA D MAIA R | 2014 | Agricultural Water Management2014，146，： | 1 |
| 6 | Synthesis of utility systems with variable demands using simulated annealing显示文摘 | Maia L O A Vidal L A Qassim R Y | 1997 | Comp & Chem Eng1997，21，： | 1 |
| 7 | Immunological evaluation of a 26 ku antigen from Taenia solium larvae for specific immunodiagnosis of human neurocysticercosis 显示文摘 | Ev L V Maia A A Pianetti G | 1999 | Parasitol Res1999，85，2： | 1 |
| 8 | Angioten sin(1-7) antagonist A-779 attenuates the potentiation of bra dykinin by captopril in rats 显示文摘 | MAIA L G RAMOS M E FERNANDES L | 2004 | J Cardiovasc Pharmacol2004，43，： | 1 |
| 9 | Solutions for a resonant elliptic system with coupling in RN显示文摘 | Furtado M F Maia L A Silva E A B | | 0，，： | 1 |
| 10 | Efficacy of continuous glucose monitoring system to detect unrecognized hypoglycemia in children and adolescents with type 1 diabetes显示文摘 | MAIA F F ARA(U)JO L R | 2005 | Arq Bras Endocrinol Metabol2005，49，4： | 1 |
| 11 | Film growth and relationship between microstructure and mechanical properties of a-C: H: F films deposited by PECVD显示文摘 | Maia da Costa M E H Jacobsohn L G | 2001 | Diamond and Related Materials2001，10，： | 1 |
| 12 | Antipredatory secosterols from the octocoral Pseudopterogorgia americana显示文摘 | Epifanio R Maia L F Pawlik J R et a1 | 2007 | Mar Ecol Prog Ser2007，329，： | 1 |
| 13 | The Brazilian consensus for the diagnosis and treatment of hyperthyroidism:recommendations by the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism显示文摘 | Maia A L Scheffel R S Meyer E L S | 2013 | Arquivos brasileiros de endocrinologia e metabologia2013，57，3： | 1 |
| 14 | Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumcn显示文摘 | Maia M R G Chaudhary L C Figueres L | 2007 | Antonie van Leeuwenhoek2007，91，： | 1 |
| 15 | Alternatives to conventional methods of surface preparation for ship repairs显示文摘 | Carlos da Maia M L | 2000 | Journal of Protective Coatings and Linings2000，17，5： | 1 |
| 16 | Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium,Butyrivibrio fibrisolvens显示文摘 | Maia M R G Chaudhary L C Bestwick C S | 2010 | BMC Microbiology2010，10，： | 1 |
| 17 | Driving force distillation and exergy loss in the thermodynamic analysis of distillation columns 显示文摘 | ZEMP R J DE FARIA S H B DE L OLIVEIRA MAIA M | 1997 | Comp Chem Eng1997，，： | 1 |
| 18 | Effect of arbuscular mycorrhizal fungi on the acclimatization of micropropagated banana planters 显示文摘 | YANO-MELO A M MAIA L C SAC GIN O J JR | 1999 | Mycorrhiza1999，9，2： | 1 |
| 19 | Wind velocity andsand transport on a barchan dune显示文摘 | Sauermann G Andrade J S Maia L P | 2003 | Geomorphology2003，54，34： | 1 |
| 20 | Use of zirconium in microalloyed steels显示文摘 | Maia A R B Guinancio C R Germano R L | | 0，，： | 1 |
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