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| 1 | Sentinel lymph node biopsy in clinically detected ductal carcinoma in situ显示文摘AIM:To study the indications for sentinel lymph node biopsy(SLNB) in clinically-detected ductal carcinoma in situ(CD-DCIS).METHODS:A retrospective analysis of 20 patients with an initial diagnosis of pure DCIS by an image-guided core needle biopsy(CNB) between June 2006 and June 2012 was conducted at King Faisal Specialist Hospital.The accuracy of performing SLNB in CD-DCIS,the rate of sentinel and non-sentinel nodal metastasis,and the histologic underestimation rate of invasive cancer at initial diagnosis were analyzed.The inclusion criteria were a preoperative diagnosis of pure DCIS with no evidence of invasion.We excluded any patient with evidence of microinvasion or invasion.There were two cases of mammographically detected DCIS and 18 cases of CDDCIS.All our patients were diagnosed by an imageguided CNB except two patients who were diagnosed by fine needle aspiration(FNA).All patients underwent breast surgery,SLNB,and axillary lymph node dissection(ALND) if the SLN was positive.RESULTS:Twenty patients with an initial diagnosis of pure DCIS underwent SLNB,2 of whom had an ALND.The mean age of the patients was 49.7 years(range,35-70).Twelve patients(60%) were premenopausal and 8(40%) were postmenopausal.CNB was the diagnostic procedure for 18 patients,and 2 who were diagnosed by FNA were excluded from the calculation of the underestimation rate.Two out of 20 had a positive SLNB and underwent an ALND and neither had additional non sentinel lymph node metastasis.Both the sentinel visualization rate and the intraoperative sentinel identification rate were 100%.The false negative rate was 0%.Only 2 patients had a positive SLNB(10%) and neither had additional metastasis following an ALND.After definitive surgery,3 patients were upstaged to invasive ductal carcinoma(3/18 = 16.6%) and 3 other patients were upstaged to DCIS with microinvasion(3/18 = 16.6%).Therefore the histologic underestimation rate of invasive disease was 33%.CONCLUSION:SLNB in CD-DCIS is technically feasible and highly accurate.We recommend limiting SLNB to patients undergoing a mastectomy. | Ahmed Yahia Al-Ameer Sahar Al Nefaie Badria Al Johani Ihab Anwar Taher Al Tweigeri Asma Tulbah Mohmmed Alshabanah Osama Al Malik | 2016 | World Journal of Clinical Oncology2016，7，2： | 3 |
| 2 | Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion显示文摘 | Rahman A Anwar KN True AL Malik AB | 1999 | J Immunol1999，162，： | 1 |
| 3 | Task force of the european society of cardiology and North American society of pacing and eleetrophysiology, Heart rate varicbility standards of measurement, physiological interpretation and clinical use 显示文摘 | Camm AI Malik M Bigger JE et al | 1996 | Circulation1996，93，： | 1 |
| 4 | Interleukin-lbeta inhibits gam- ma-aminobutyric acid type A receptor current in cul- tured hippocampal neurons 显示文摘 | Wang S Cheng Q Malik S el al | 2000 | J Pharmacol Exp Ther2000，292，2： | 1 |
| 5 | Activation of NF-kappa B induced by H(2)O(2) and TNF-alpha and its effects on ICAM-1 expression in endothelial cells显示文摘 | True AL Rahman A Malik AB | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，2： | 1 |
| 6 | De-creased axillary lymph node retrieval in patients after neoadjuvantchemotherapy显示文摘 | BASLAIM M M AL MALIK 0 A AL SOBHI S S | 2002 | Am J Surg2002，184，4： | 1 |
| 7 | QT dispersionprobloms of methodology and clinical significance 显示文摘 | Statters D J Malik M Ward D E ~ al | 1994 | JCardiovasc Electrophysical1994，5，8： | 1 |
| 8 | Activation of NF-B induced by H2O2 and TNF- and its effects on ICAM-1 expression in endothelial cells显示文摘 | True AL Rahman A Malik AB | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，2： | 1 |
| 9 | Of the Europen Society ofcardiology and North American Society of pacing and electrophysiology;heart rate variability standayds of measure ment physiological interpretation and clinical use显示文摘 | Camm AL Malik M Bigger JT | 1996 | Circulation1996，93，： | 1 |
| 10 | Decreased axillary lymph node retrieval in patients after neoadjuvant chemotherapy显示文摘 | Baslaim MM Al Malik OA Al Sobhi SS | 2002 | Am J Surg2002，184，4： | 1 |
| 11 | Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy:implications for therapy显示文摘 | Malik B Nirmalananthan N Gray AL | 2013 | Brain2013，136，3： | 1 |
| 12 | Multicentric reticulohistiocytosis显示文摘 | Tajirian AL Malik MK Robinson-Bostom L | 2006 | Clin Dermatol2006，24，6： | 1 |
| 13 | Decreasedaxillary lymph node retrieval in patients after neoadjuvantchemotherapy 显示文摘 | Baslaim MM Al Malik OA Al-Sobhi SS | 2002 | Am J Surg2002，184，4： | 1 |
| 14 | Pmduclion of the anticanccr drug taxol in Taxus baccala suspension cul- lures: a review 显示文摘 | Malik S Cusido R M Mirjalili M It el al | 2011 | Process Biochemistry2011，46，1： | 1 |
| 15 | Preoperative neutrophil- to-lymphocyte ratio as a prognostic predictor aitcr curative resection for hcpatoccllular carcinoma 显示文摘 | Gomcz D Farid S Malik HZ ct al | 2008 | World J Surg2008，32，8： | 1 |
| 16 | Time trends over five decades,and recent geographical vari- ation, in rates of childhood squint surgery in England显示文摘 | Munazzah R Chou Aeesha N J Malik Mehrunisha Suleman et al | 2013 | Br J Oohthalmol2013，97，6： | 1 |
| 17 | Occurrcnce, Finger Printing and Ecological Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) in the Chcnab River, Pakistan 显示文摘 | Farooq S Eqani S AMAS Malik R N ct al | 2011 | Journal of EnvironmentalMonitoring2011，13，11： | 1 |
| 18 | Contour and Texture Analysis for Image Segmentation显示文摘 | Malik J Belongie F Leugn T at al | 2001 | Journal of Computer Vision2001，43，1： | 1 |
| 19 | in pure culture and groundwater 显示文摘 | CACERES TP MEGHARAJ M MALIK S et aL Hydrolysis of fenamiphos and its toxic oxidation products by Mi- crobacterium sp | 2009 | Bioresource Technol- ogy2009，100，10： | 1 |
| 20 | Ca^2+ signalling and PK- Calpha activate increased endothelial permeability by disassembly of VE-cadherin junctions 显示文摘 | Sandoval R Malik A B Minshall R D el al | 2001 | J Physiol2001，533，2： | 1 |
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