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| 1 | Pyrrolidine dithiocarbamate reduces ischemia-reperfusion injury of the small intestine显示文摘AIM: To evaluate whether pyrrolidine dithiocarbamate (PDTC), an enhancer of HO production, attenuates intestinal IR injury.METHODS: Eighteen male rats were randomly allocated into three groups: (a) sham; (b) IR, consisting of 30 min of intestinal ischemia, followed by 2-h period of reperfusion; and (c) PDTC treatment before IR. Intestinal microvascular perfusion (IMP) was monitored continuously by laser Doppler fiowmetry. At the end of the reperfusion, serum samples for lactate dehydrogenase (LDH) levels and biopsies of ileum were obtained. HO activity in the ileum was assessed at the end of the reperfusion period.RESULTS: At the end of the reperfusion in the IR group,IMP recovered partially to 42.5% of baseline (P<0.05vs sham), whereas PDTC improved IMP to 67.3% of baseline (P<0.01 vs IR). There was a twofold increase in HO activity in PDTC group (2 062.66±106.11) as compared to IR (842.3±85.12) (P<0.001). LDH was significantly reduced (P<0.001) in PDTC group (585.6±102.4)as compared to IR group (1 973.8±306.5). Histological examination showed that the ileal mucosa was significantly less injured in PDTC group as compared with IR group.CONCLUSION: Our study demonstrates that PDTC improves the IMP and attenuates IR injury of the intestine possibly via HO production. Additional studies are warranted to evaluate the clinical efficacy of PDTC in the prevention of IR injury of the small intestine. | Ismail H Mallick Wen-Xuan Yang Marc C Winslet Alexander M Seifalian | 2005 | World Journal of Gastroenterology2005，11，46： | 8 |
| 2 | Situs inversus abdominus and malrotation in an adult with Ladd's band formation leading to intestinal ischaemia显示文摘地点在对有肠的旋转异例的 abdominus 是一个极其稀罕的条件。尽管肠的旋转不良在婴儿和孩子作为阻塞的一个原因被认出了并且可能由肠的 ischaemia 复杂,它在成年人是很稀罕的。当它发生在成年病人时,它可以作为含糊的断断续续的腹的疼痛作为肠阻塞或肠的 ischaemia 或长期地尖锐地介绍。此处,我们在场与 Ladd 在 32 岁女人导致肠的梗塞的乐队一起的地点在对 abdominus 和肠的旋转不良的一个案例的一个尖锐演讲。 | Ismail H Mallick Rizwan Iqbal Justin B Davies | 2006 | World Journal of Gastroenterology2006，12，25： | 3 |
| 3 | Use of chlorophyll fluorescence in metal-stress research :A case study with the green microalga Scenedesmus 显示文摘 | MALLICK N MOHN F H | 2003 | Ecotoxicology and Enviromental Safety2003，55，： | 1 |
| 4 | pNR-2/pS2 immunohistochemical staining in breast cancer :correlation with prognostic factors and endocrine response显示文摘 | Piggott N H Mallick U K | 1991 | Br J Cancer1991，63，4： | 1 |
| 5 | Changes in sleep-wakefulness in the medial preoptic area lesioned rats:role of thermal preference显示文摘 | Ray B Mallick H N Kumar V M | 2005 | Behav Brain Res2005，158，1： | 1 |
| 6 | One-step solution for the multistep out-of-sequence measurement problem in tracking显示文摘 | Bar-Shalom Y Chen H Mallick M | | 0，，01： | 1 |
| 7 | Impact of physiological stresses on nitric oxide formation by green alga, Scenedesnues obligus显示文摘 | MALLICK N MOHN F H SOEDER C J | 2000 | J Microbiology and Biotechnology2000，110，2： | 1 |
| 8 | A numerical study on the quasi-static crush characteristics of square a- luminum-composite hybrid tubes 显示文摘 | EI-HAGE H MALLICK P K ZAMANI N | 2006 | Composite Struc- tures2006，73，4： | 1 |
| 9 | Ischemia-reperfusion injury of the intestine and protective strategies against injury 显示文摘 | Mallick I H Yang W Winslet M C | 2004 | Dig DisSci2004，49，9： | 1 |
| 10 | One-step solution for the multistep out-of-sequence measurement problem in tracking 显示文摘 | Bar-Shalom Mallick Y Chen H M | 2004 | IEEE Transaction on AES2004，40，1： | 1 |
| 11 | Use of chlorophy|l fluorescence in metal - stress research:a case study with the green microalga Scenedes - mus显示文摘 | Mallick N Mohn F H | 2003 | Ecotoxicology and Environmental Safety2003，55，1： | 1 |
| 12 | Escheriosomes entrapped DNA vaccine co-expressing Cu-Zn superoxide dismutase and IL-18 con- fers protection against Brucella abortus 显示文摘 | Singha H Mallick AI Jana C | 2008 | Microbes Infect2008，10，1011： | 1 |
| 13 | Thermal comfort and building design in the tropical climates 显示文摘 | Mallick F H | 1996 | Energy and Buildings1996，23，3： | 1 |
| 14 | Intracerebroven-tricular injection oforexin-2 receptor antagonist promotes REM sleep 显示文摘 | Kmmnangal B A Kumar D Mallick H N | | Behav Br liz Res 213130，237，1： | 1 |
| 15 | Pollution prevention with chemical process simulators:the generalized waste reduction (WAR) algorithm-full version 显示文摘 | CABEZAS H BARE J C MALLICK S K | 1999 | Computer& Chemical Engineering1999，23，45： | 1 |
| 16 | Si/SiC ceramics from wood of Indian dicotyledonous mango tree 显示文摘 | Mallick D Chakrabarti O P Maiti H S | 2007 | Ceramics International2007，33，7： | 1 |
| 17 | Geosounding Principles显示文摘 | PATRA H P MALLICK K | 1980 | Time Variying Geoelectric Soundings1980，，： | 1 |
| 18 | One-step So- lution for the Genertl Out-of-sequence Measurement Prob- lem in Tracking 显示文摘 | BAR-Shalom Y Mallick M ChenN H etal | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，4，1： | 1 |
| 19 | Concomitant activation of miR - 107/PDCD10 and hypoxamir -210/Casp8ap2 and their role in eytoprotection during ischemle preconditioning of stem cells 显示文摘 | Kim H W Mallick F Durrani S | 2012 | Antioxid Redox Signal2012，17，8： | 1 |
| 20 | Reactive oxygen species: Response of algal cells显示文摘 | Mallick N Mohn F H | 2000 | J Plant Physiol2000，157，： | 1 |
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