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| 1 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 2 | Investigation of Plasma Polymerized Benzene and Furan Thin Films for Application in Opto-electronie Devices显示文摘 | JOBANPUTRA Manish C DURSTOCK Michael F CLARSON Stephen J | 2003 | Journal of Applied Polymer Science2003，，87： | 1 |
| 3 | Image Texture Analysis:Methods and Comparisons显示文摘 | Manish H B Liu J J John F M | 2004 | Chemometrics and Intelligent Laboratory Systems2004，72，： | 1 |
| 4 | Design and development of multivesicular liposomal depot delivery system for controlled systemic delivery of acyclovir sodium 显示文摘 | Sanjay K J Rajesh K J Manish K | 2005 | AAPS Pharm Sci2005，6，1： | 1 |
| 5 | Image texture analysis: Methods and comparisons 显示文摘 | MANISH B H LIU J J JOHN G F M | 2004 | Chemomtrics and Intelligent Laboratory2004，72，1： | 1 |
| 6 | Studies of Novel Water-Soluble Colored Polyesters Containing Azo Moiety 显示文摘 | Manish P Patel Bhavin J Modi Ranjan G Patel | 1998 | Journal Applied Polymer Science1998，69，12： | 1 |
| 7 | Cross-linked guar gum microspheres a viable approach for improved delivery of anticancer drugs for the treatment of colorectal cancer显示文摘 | Mohini C Manish K C Nitin K J | 2006 | AAPS Pharm Sci Tech2006，7，3： | 1 |
| 8 | Image Tex- ture Analysis: Methods and Comparisons 显示文摘 | Bharati Manish H Liu J Jay MacGregor John F | 2004 | Chemometrics and Intelligent laboratory Systems2004，72，1： | 1 |
| 9 | Melt sonocrystallization of ibuprofen:Effect on crystal properties显示文摘 | MANISH M HARSHAL J ANANT P | 2005 | Eur J Pharm Sci2005，25，1： | 1 |
| 10 | End-to-end available bandwidth:measurement methodology,dynamics,and relation with TCP throughput显示文摘 | MANISH J CONSTANTINOS D | 2003 | IEEE/ACM Transactions on Networking2003，11，4： | 1 |
| 11 | A novel method to measure cleanliness in steel using ultrasonic e-scan image analysis显示文摘 | Pandely J C Manish RAJ ROY T K | 2008 | Metallurgical and Materials Transactions B2008，39，3： | 1 |
| 12 | Image texture analysis: Meth- ods and comparisons 显示文摘 | MANISH B H LIU J J JOHN G F M | 2004 | Chemomtrics and Intelligent Laboratory2004，72，1： | 1 |
| 13 | Correlation of spectral domain optical coherence tomography findings in sub-silicone oil foveal depression space and visual outcome in eyes undergoing silicone oil removal显示文摘 | Manish N Kalyani J B Pravin J | 2016 | Taiwan Journal of Ophthalmology2016，6，1： | 1 |
| 14 | Synthesis of 7-substitu- ted 4-methylcoumarins by Pechmann reaction using nano-crystalline sulfated-zirconia显示文摘 | Beena T Manish K M Raksh V J | 2007 | Journal of Molecular Ca- talysis A : Chemical2007，276，： | 1 |
| 15 | Melt Sonocrystallization of Ibuprofen:Effect on Crystal Properties显示文摘 | Manish M Harshal J Anant P | 2005 | European Journal of Pharmaceutical Sciences2005，25，： | 1 |
| 16 | Design and dev-elopment of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability显示文摘 | PRADIP K G RITA J M MANISH L U | 2006 | AAPS Pharm Sci Tech2006，7，3： | 1 |
| 17 | Noroviruses:a comprehensive review显示文摘 | Patel Manish M Hall Aron J Vinje Jan | 2009 | J clin virol2009，44，1： | 1 |
| 18 | Discriminant analysis of edible oils and fats by FTIR,FT-NIR and FT-Raman spectroscopy显示文摘 | Yang H Irudayaraj J Manish M P | 2005 | Food Chemistry2005，93，： | 1 |
| 19 | Synthesis and mechanical properties of nanocrystalline MoSi2-SiC composite显示文摘 | MANISH P SUBRAMANYUAM J PRASAD V V B | 2008 | Scripta Materialia2008，58，3： | 1 |
| 20 | Image Texture Analysis: Methods and Comparisons 显示文摘 | Manish H Bharatil J Jay Liu John F MacGregor | 2004 | Chemometrics and Intelligent Laboratory Systems2004，72，1： | 1 |
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