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| 1 | 非胰岛素依赖型糖尿病冠状动脉疾病的危险因素:英国糖尿病前瞻性研究(UKPDS:23)显示文摘目的:评价2型糖尿病患者冠状动脉疾病的基线危险因素。设计:对2 693例资料完整的患者进行年龄和性别调整的逐步选择过程分析,以确定哪些冠状动脉疾病的危险因素应纳入 Cox 比例风险模型。对象:3 055例白人患者,平均年龄52岁,均新近诊断为2型糖尿病,且无动脉粥样硬化相关疾病的证据。平均随访期7.9年。335例患者于10年内出现冠状动脉疾病。结局评定:具有明确异常心电图的心绞痛、致死或非致死性心肌梗塞。结果:冠状动脉疾病与低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、甘油三酯浓度升高、高血红蛋白 A_(1c)、高收缩压、高空腹血糖以及吸烟史密切相关。低密度脂蛋白胆固醇较高1/3对较低1/3区间的估计风险比为2.26(95%可信区间为1.70~3.00),高密度脂蛋白胆固醇为0.55(0.41~0.73),血红蛋白 A_(1c)为1.52(1.15~2.01),收缩压为1.82(1.34~2.47)。吸烟者的估计风险比为1.41(1.06~1.88)。结论:2型糖尿病患者中,存在冠状动脉疾病潜在的、可变的5种危险因素的交叉重叠影响。它们是低密度脂蛋白胆固醇浓度升高、高密度脂蛋白胆固醇浓度降低、高血压、高血糖和吸烟。 | R C Turner H Millns H A W Neil I M Stratton S E Manley D R Matthews R R Holman 赵维纲 | 1998 | 英国医学杂志中文版1998，0，3： | 11 |
| 2 | New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases显示文摘Alcoholic liver disease is a major health problem in the United States and worldwide. Chronic alcohol consumption can cause steatosis, inflammation, fibrosis, cirrhosis and even liver cancer. Significant progress has been made to understand key events and molecular players for the onset and progression of alcoholic liver disease from both experimental and clinical alcohol studies. No successful treatments are currently available for treating alcoholic liver disease; therefore, development of novel pathophysiological-targeted therapies is urgently needed. This review summarizes the recent progress on animal models used to study alcoholic liver disease and the detrimental factors that contribute to alcoholic liver disease pathogenesis including miRNAs, S-adenosylmethionine, Zinc deficiency, cytosolic lipin-1β, IRF3-mediated apoptosis, RIP3-mediated necrosis and hepcidin. In addition, we summarize emerging adaptive protective effects induced by alcohol to attenuate alcohol-induced liver pathogenesis including FoxO3, IL-22, autophagy and nuclear lipin-1α. | Jessica A Williams Sharon Manley Wen-Xing Ding | 2014 | World Journal of Gastroenterology2014，20，36： | 10 |
| 3 | Volumetric Visualization: An Effective use of GIS Technology in the Field of Oceanography 显示文摘 | Manley T O Tallet J A | 1990 | Oceanography1990，3，： | 1 |
| 4 | Volumetric visualization:an effective use of GIS technology in the field of oceanography显示文摘 | Manley T O Tallet J A | | 0，，01： | 1 |
| 5 | Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research 显示文摘 | Nakagawa A Manley GT Gean AD | 2011 | J Neurotrauma2011，28，6： | 1 |
| 6 | Timing of volcanism in the Sierra Nevada of California:Evidence for Pliocene delamination of the batholithic root?显示文摘 | Manley C R Glazner A F Farmer G L | 2000 | Geology2000，28，： | 1 |
| 7 | DNA-depend- ent transcription Of adenovirus genes in a soluble whole- cell extract显示文摘 | MANLEY J L FIRE A CANO A | 1980 | Proc Natl Acad Sci U S A1980，77，： | 1 |
| 8 | Medication-related Problems in Ambulatory Hemodialysis Patients:a Pooled Analysis显示文摘 | Manley H J Cannella C A Bailie G R | 2005 | Am J Kidney Dis2005，46，4： | 1 |
| 9 | Did lithospheric delamination trigger late Cenozoic potassic volcanism in the southern Sierra Nevada,California?显示文摘 | Farmer G L Glazner A F Manley C R | 2002 | Geological Society of America Bulletin2002，114，： | 1 |
| 10 | Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research 显示文摘 | Nakagawa A Manley GT Gean AD | | J Neurotrauma0，28，6： | 1 |
| 11 | The effects of gamma irradiation on the microbiological,physical and sensory qualities of diced tomatoes显示文摘 | Prakash A Manley J DeCosta S | 2002 | Radiation Physics and Chemistry2002，63，： | 1 |
| 12 | Key influences on construction innovation显示文摘 | BLAYSE A M MANLEY K | 2004 | Construction Innovation:Information Process Management2004，4，3： | 1 |
| 13 | Women Entrepreneurs and Financial Capital 显示文摘 | Orser B and riding A Manley C | 2006 | Entrepreneurship: Theory and Practice2006，30，5： | 1 |
| 14 | Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain显示文摘 | Zador Z Magzoub M Jin S Manley G T Papadopoulos M C Verkman A S | 2008 | FASEB J2008，22，： | 1 |
| 15 | The effects of gamma irradiation on the microbiological, physical and sensory qualities of diced tomatoes 显示文摘 | Prakash A Manley J Decosta S | 2002 | Radiation Physics and Chemistry2002，63，6： | 1 |
| 16 | A survey of energy policy priorities in the United States: energy supply security, economics, and the environment 显示文摘 | Manley D K Hines V A Jordan M W | 2013 | Energy Policy2013，60，9： | 1 |
| 17 | Morphology of abyssal mudwaves at Project MUDWAVES sites in the Argentine Basin显示文摘 | Flood R D Shor A N Manley P D | 1993 | Deep-Sea Research1993，40，： | 1 |
| 18 | Interleukin 10 extends the effectiveness of standard therapy during late sepsis with serum interleukin 6 levels predicting outcome显示文摘 | Manley M O O'Riordan M A Levine A D etal | 2005 | Shock2005，23，6： | 1 |
| 19 | Fixation of Acetabular Cups without Cement in Total Hip Arthroplasty-A Comparison of Three Different Implant Surfaces at a Minimum Duration of Follow-up of Five Years显示文摘 | MANLEY M T C DAANTONIO W N EDIN J A | 1998 | J Bone Jt Surg1998，80，： | 1 |
| 20 | Key influences on construction innovation 显示文摘 | BLAYSE A M MANLEY K | 2004 | Construction Innovation: Information Process Management2004，4，3： | 1 |
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