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| 1 | Intestinal antigen-presenting cells in mucosal immune homeostasis:Crosstalk between dendritic cells,macrophages and B-cells显示文摘The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota.Inflammatory bowel disease(IBD)involves a breakdown in tolerance towards the microbiota.Dendritic cells(DC),macrophages(MΦ)and B-cells are known as professional antigen-presenting cells(APC)due to their specialization in presenting processed antigen to T-cells,and in turn shaping types of T-cell responses generated.Intestinal DC are migratory cells,unique in their ability to generate primary T-cell responses in mesenteric lymph nodes or Peyer’s patches,whilst MΦand B-cells contribute to polarization and differentiation of secondary T-cell responses in the gut lamina propria.The antigen-sampling function of gut DC and MΦenables them to sample bacterial antigens from the gut lumen to determine types of T-cell responses generated.The primary function of intestinal B-cells involves their secretion of large amounts of immunoglobulin A,which in turn contributes to epithelial barrier function and limits immune responses towards to microbiota.Here,we review the role of all three types of APC in intestinal immunity,both in the steady state and in inflammation,and how these cells interact with one another,as well as with the intestinal microenvironment,to shape mucosal immune responses.We describe mechanisms of maintaining intestinal immune tolerance in the steady state but also inappropriate responses of APC to components of the gut microbiota that contribute to pathology in IBD. | Elizabeth R Mann Xuhang Li | 2014 | World Journal of Gastroenterology2014，20，29： | 19 |
| 2 | A Review of the Functional and Anatomical Default Mode Network in Schizophrenia显示文摘Schizophrenia is a severe mental disorder characterized by impaired perception,delusions,thought disorder,abnormal emotion regulation,altered motor function,and impaired drive. The default mode network(DMN),since it was first proposed in 2001,has become a central research theme in neuropsychiatric disorders,including schizophrenia. In this review,first we define the DMN and describe its functional activity,functional and anatomical connectivity,heritability,and inverse correlation with the task positive network. Second,we review empirical studies of the anatomical and functional DMN,and anti-correlation between DMN and the task positive network in schizophrenia. Finally,we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN,review the role of DMN as a treatment biomarker for this disease,and consider the DMN effects of individualized therapies for schizophrenia. | Mao-Lin Hu Xiao-Fen Zong J. John Mann Jun-Jie Zheng Yan-Hui Liao Zong-Chang Li Ying He Xiao-Gang Chen Jin-Song Tang | 2017 | Neuroscience Bulletin2017，33，1： | 19 |
| 3 | Reconsideration of the phylogenetic positions of three stichotrichous genera Holosticha,Anteholosticha and Pseudokeronopsis (Spirotrichea:Ciliophora) inferred from complete SSU rRNA gene sequences显示文摘The small subunit rRNA (SSU rRNA) gene for six marine stichotrichs, Pseudokeronopsis carnea, P. flava, Holosticha heterofoissneri, H. diademata, H. bradburyae and Anteholosticha manca, was sequenced and characterized. Using this molecular information, the phylogenetic positions of three related genera, Pseudokeronopsis, Holosticha and Anteholosticha were determined. The results indicate that the family Urostylidae is clearly separated from the family Pseudokeronopsidae. The present phylogenetic analyses unambiguously placed Pseudokeronopsis close to Holosticha, and support the conclusion that these genera should be regarded as the members of the order Urostylidae within the stichotrich clade. Furthermore, the results of this study also support the monophyly of the genus Pseud-okeronopsis, the redefinition of Holosticha s. str. and the placement of Anteholosticha in a clade separate from Holosticha. | Lifang Li Weibo Song Mann Kyoon Shin Alan Warren Khaled A.S. Al-Rasheid Abdulaziz A. Al-Khedhairy Saud Al-Arifi | 2009 | Progress in Natural Science:Materials International2009，19，6： | 3 |
| 4 | Error measurements for flank milling 显示文摘 | Chengggang Li Stephen Mann Sanjeev Bedia | 2005 | Computer- aided design2005，，37： | 1 |
| 5 | Fenofibrate attenuates tubulointerstitial fibrosis and inflammation through suppression of nuclear factor-kappaB and transforming growth factor-beta1/Smad3 in diabetic nephropathy显示文摘 | Li L Emmett N Mann D | | 0，，： | 1 |
| 6 | DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages显示文摘 | Maatouk D.M Kellam L.D Mann M.R W Lei H Li E Bartolomei M.S Rcsnick J.L | | 0，，17： | 1 |
| 7 | Synthesis of prussianblue nanoparticles and nanoparticles superlattices inreverse microemulsions显示文摘 | Vaucher S Li M Mann S | 2000 | Angew Chem Int Ed2000，39，： | 1 |
| 8 | Coupled synthesis and self-assembly of nanoparticles to given structures with controlled organization显示文摘 | M Li H Schnablegger S Mann | 1999 | Nature1999，402，： | 1 |
| 9 | 显示文摘 | Li M Schnablesser H Mann S | 1999 | Nature1999，402，： | 1 |
| 10 | Error measurements for flank milling显示文摘 | LI C G MANN S BEDI S | 2005 | Computer-Aided Design2005，37，14： | 1 |
| 11 | Fenofibrate attenuates tubulointersti- fial fibrosis and inflammation through suppression of nuclear factor - kB and transforming growth factor - β1/Smad3 in diabetic nephropathy 显示文摘 | Li L Emmett N Mann D | 2010 | Exp Biol Med (Maywood)2010，235，3： | 1 |
| 12 | Synthesis of prussian blue nanoparticles and nanocrystal superlattices in reverse microemulsions 显示文摘 | VAUCHER S LI M MANN S | 2000 | Angerwandte Chemie - International Edition2000，39，10： | 1 |
| 13 | Preferential growth of semiconducting single-walled carbon nanotubes by a plasma enhanced CVD method显示文摘 | LI Yiming MANN D ROLANDI M | 2004 | Nano Lett2004，4，2： | 1 |
| 14 | A COLIA1 Spl binding site polymorphism predisposes to osteoporotic fracture by affect ing bone density and quality显示文摘 | MANN V HOBSON E E LI B | 2001 | J Clin Invest2001，107，7： | 1 |
| 15 | A COLIAl Spl binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality 显示文摘 | Mann V Hobson EE Li B | 2001 | J Clin Invest2001，107，7： | 1 |
| 16 | Coupled synthesis and self-assembly of nanoparticles to give structures with controlled organization显示文摘 | Li M Schnablegger H Mann S | 1999 | Nature1999，402，6760： | 1 |
| 17 | Fenofibrate attenuates tubulointerstitial fibrosis and inflammation through suppression of nuclear factor-KB and transforming growth factor-β1/Smad3 in diabetic nephropathy 显示文摘 | Li L Emmett N Mann D | 2010 | Experimental biology and medicine2010，235，3： | 1 |
| 18 | Programmed assembly of multilayered protein/nanoparticle-carbon nanotube conjugates显示文摘 | Li M Dujardin E Mann S | 2005 | Chem Commun2005，，： | 1 |
| 19 | Coupled synthesis and serf-assembly of nanoparticles to give structures with controlled organization显示文摘 | Li M Schnablegger H Mann S | 1999 | Nature1999，402，： | 1 |
| 20 | Additive-mediated crystallization of complex calcium carbonate superstructures in reverse microemulsions显示文摘 | Thachepan S Li M Mann S | 2006 | Chem Mater2006，18，15： | 1 |
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