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| 1 | Yin and Yang of mesenchymal stem cells and aplastic anemia显示文摘Acquired aplastic anemia(AA) is a bone marrow failure syndrome characterized by peripheral cytopenias and bone marrow hypoplasia. It is ultimately fatal without treatment, most commonly from infection or hemorrhage. Current treatments focus on suppressing immune-mediated destruction of bone marrow stem cells or replacing hematopoietic stem cells(HSCs) by transplantation. Our incomplete understanding of the pathogenesis of AA has limited development of targeted treatment options. Mesenchymal stem cells(MSCs) play a vital role in HSC proliferation; they also modulate immune responses and maintain an environment supportive of hematopoiesis. Some of the observed clinical manifestations of AA can be explained by mesenchymal dysfunction. MSC infusions have been shown to be safe and may offer new approaches for the treatment of this disorder. Indeed, infusions of MSCs may help suppress auto-reactive, T-cell mediated HSC destruction and help restore an environment that supports hematopoiesis. Small pilot studies using MSCs as monotherapy or as adjuncts to HSC transplantation have been attempted as treatments for AA. Here we review the current understanding of the pathogenesis of AA and the function of MSCs, and suggest that MSCs should be a target for further research and clinical trials in this disorder. | Larisa Broglie David Margolis Jeffrey A Medin | 2017 | World Journal of Stem Cells2017，9，12： | 3 |
| 2 | Review of application of mass spectrometry for analyses of anterior eye proteome显示文摘Proteins have important functional roles in the body, which can be altered in disease states. The eye is a complex organ rich in proteins; in particular, the anterior eye is very sophisticated in function and is most commonly involved in ophthalmic diseases. Proteomics, the large scale study of proteins, has greatly impacted our knowledge and understanding of gene function in the post-genomic period. The most significant breakthrough in proteomics has been mass spectrometric identification of proteins, which extends analysis far beyond the mere display of proteins that classical techniques provide. Mass spectrometry functions as a 'mass analyzer' which simplifies the identification and quantification of proteins extracted from biological tissue. Mass spectrometric analysis of the anterior eye proteome provides a differential display for protein comparison of normal and diseased tissue. In this article wepresent the key proteomic findings in the recent literature related to the cornea, aqueous humor, trabecular meshwork, iris, ciliary body and lens. Through this we identified unique proteins specific to diseases related to the anterior eye. | Sherif Elsobky Ashley M Crane Michael Margolis Teresia A Carreon Sanjoy K Bhattacharya | 2014 | World Journal of Biological Chemistry2014，5，2： | 2 |
| 3 | Randomized,double-blind comparison of immediate-release omeprazole oal suspension versus intravenous cimetiding for the prevention of upper gastrointestinal bleeding in critically ill patients显示文摘 | Conrad SA Gabrielli A Margolis B | 2005 | Crit care med2005，33，4： | 1 |
| 4 | Randomized, double - blind comparison of immediate - release omeprazole oral suspension versus intravenous cimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients 显示文摘 | Conrad SA Gabrielli A Margolis B | 2005 | Crit Care Med2005，33，4： | 1 |
| 5 | Growth and physiological response of eastern white pine seedlings to partial cutting and site preparation显示文摘 | Boucher J F Bernier P Y Margolis H A Munson A D | | 0，，： | 1 |
| 6 | Navigating The Bind of Necessary Evils:Psychological Engagement and The Production of Interpersonally Sensitive Behavior显示文摘 | Margolis J Molinsky A | 2008 | Academy of Management Journal2008，，5： | 1 |
| 7 | High altitude sludge composting显示文摘 | William H S Margolis Z P Janonis B A | 1992 | Biocycle1992，8，： | 1 |
| 8 | High attitude sludge composting显示文摘 | Smith W H Margolis Z P Janonis B A | 1992 | Biocycle1992，，8： | 1 |
| 9 | A method for valuing global ecosystem services 显示文摘 | ALEXANDER A M LIST J A MARGOLIS A | 1998 | Ecological Economics1998，27，2： | 1 |
| 10 | Automated coronary plaque characterisation with intravascular ultrasound backsaetter: ex vivo validation 显示文摘 | Nair A Margolis MP Kuban BD | 2007 | Euro Interven2007，3，10： | 1 |
| 11 | Does It Pay to be Good?A Meta-Analysis and Redirection of Research on The Relationship Between Corporate Social and Financial Performance显示文摘 | Margolis J D Elfenbein H A Walsh J P | 2007 | Ann Arbor2007，，48： | 1 |
| 12 | Noninvasive staging of non-small cell lung cancer:ACCA evidenced-based clinical practice guidelines(2nd edition)显示文摘 | Silvestri G A Gould M K Margolis M L | 2007 | Chest2007，132，： | 1 |
| 13 | Preliminary development of a diabetic foot ulcer database from a wound electronic medical record:A tool to decrease limb amputations显示文摘 | Golinko MS Margolis DJ Tal A | | 0，，： | 1 |
| 14 | Trinucleotide repeat expansion and neuropsychiatric disease 显示文摘 | Margolis RL McInnis MG Rosenblatt A | 1999 | Arch Gen Psychiatry1999，56，： | 1 |
| 15 | High altitude sludge composting显示文摘 | William H S Margolis P Janonis B A | 1992 | Biocycle1992，8，： | 1 |
| 16 | Stability of quasi-steady deflagrations in confined porous energetic materials显示文摘 | Telengator A M Margolis S B Williams F A | 2000 | Combst Sci Tech2000，，160： | 1 |
| 17 | Randomized double blind comparison of immediate release cmepmrole oral susperision versus intraverious eimetidine for the prevention of upper gastrointestinal bleeding in critically ill patients显示文摘 | Conrad SA Gabrielli A Margolis | 2005 | Crit Care Med2005，33，4： | 1 |
| 18 | Experience with part-Winding Resonance in EHV Auto-Transformers: Diagnosis and Corrective Measures显示文摘 | Margolis H B Phelps J D M Carlomagno A A | 1975 | IEEE Trans on PAS1975，94，4： | 1 |
| 19 | Automated coronary plaque characterization with intravascular ultrasound backscatter:ex vivo validation显示文摘 | Nair A Margolis MP Kuban BD | 2007 | EuroIntervention2007，3，： | 1 |
| 20 | Relation of light and nitrogensource to growth,nitrate reductase and glutamine synthetase activity of jackpine seedlings显示文摘 | MARGOLIS H A VEZINA L P OUIMET R | 1988 | Physiol Plant1988，72，： | 1 |
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